Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).

Detalhes bibliográficos
Autor(a) principal: MACHADO, M. A.
Data de Publicação: 2010
Outros Autores: AZEVEDO, A. L. S., TEODORO, R. L., PIRES, M. de F. A., PEIXOTO, M. G. C. D., FREITAS, C. de, PRATA, M. C. de A., FURLONG, J., SILVA, M. V. G. B., GUIMARÃES, S. E. F., REGITANO, L. C. de A., COUTINHO, L. L., GASPARIN, G., VERNEQUE, R. da S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086
https://doi.org/10.1186/1471-2164-11-280
Resumo: Background : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.
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spelling Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).Cattle resistance tickBackground : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.MARCO ANTONIO MACHADO, CNPGL; ANA LUISA SOUSA AZEVEDO, CNPGL; ROBERTO LUIZ TEODORO, Pesquisador aposentado do CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE ELIZA FACIONI GUIMARÃES, UFV; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; GUSTAVO GASPARIN, CAPES/UFSCAR; RUI DA SILVA VERNEQUE, CNPGL.MACHADO, M. A.AZEVEDO, A. L. S.TEODORO, R. L.PIRES, M. de F. A.PEIXOTO, M. G. C. D.FREITAS, C. dePRATA, M. C. de A.FURLONG, J.SILVA, M. V. G. B.GUIMARÃES, S. E. F.REGITANO, L. C. de A.COUTINHO, L. L.GASPARIN, G.VERNEQUE, R. da S.2011-04-09T16:09:24Z2011-04-09T16:09:24Z2011-03-1620102011-04-10T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBMC Genomics, v. 11, article 280, 2010.http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086https://doi.org/10.1186/1471-2164-11-280enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-15T22:07:37Zoai:www.alice.cnptia.embrapa.br:doc/881086Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542017-08-15T22:07:37falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-15T22:07:37Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
title Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
spellingShingle Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
MACHADO, M. A.
Cattle resistance tick
title_short Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
title_full Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
title_fullStr Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
title_full_unstemmed Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
title_sort Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
author MACHADO, M. A.
author_facet MACHADO, M. A.
AZEVEDO, A. L. S.
TEODORO, R. L.
PIRES, M. de F. A.
PEIXOTO, M. G. C. D.
FREITAS, C. de
PRATA, M. C. de A.
FURLONG, J.
SILVA, M. V. G. B.
GUIMARÃES, S. E. F.
REGITANO, L. C. de A.
COUTINHO, L. L.
GASPARIN, G.
VERNEQUE, R. da S.
author_role author
author2 AZEVEDO, A. L. S.
TEODORO, R. L.
PIRES, M. de F. A.
PEIXOTO, M. G. C. D.
FREITAS, C. de
PRATA, M. C. de A.
FURLONG, J.
SILVA, M. V. G. B.
GUIMARÃES, S. E. F.
REGITANO, L. C. de A.
COUTINHO, L. L.
GASPARIN, G.
VERNEQUE, R. da S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv MARCO ANTONIO MACHADO, CNPGL; ANA LUISA SOUSA AZEVEDO, CNPGL; ROBERTO LUIZ TEODORO, Pesquisador aposentado do CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE ELIZA FACIONI GUIMARÃES, UFV; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; GUSTAVO GASPARIN, CAPES/UFSCAR; RUI DA SILVA VERNEQUE, CNPGL.
dc.contributor.author.fl_str_mv MACHADO, M. A.
AZEVEDO, A. L. S.
TEODORO, R. L.
PIRES, M. de F. A.
PEIXOTO, M. G. C. D.
FREITAS, C. de
PRATA, M. C. de A.
FURLONG, J.
SILVA, M. V. G. B.
GUIMARÃES, S. E. F.
REGITANO, L. C. de A.
COUTINHO, L. L.
GASPARIN, G.
VERNEQUE, R. da S.
dc.subject.por.fl_str_mv Cattle resistance tick
topic Cattle resistance tick
description Background : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.
publishDate 2010
dc.date.none.fl_str_mv 2010
2011-04-09T16:09:24Z
2011-04-09T16:09:24Z
2011-03-16
2011-04-10T11:11:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BMC Genomics, v. 11, article 280, 2010.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086
https://doi.org/10.1186/1471-2164-11-280
identifier_str_mv BMC Genomics, v. 11, article 280, 2010.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086
https://doi.org/10.1186/1471-2164-11-280
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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