Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086 https://doi.org/10.1186/1471-2164-11-280 |
Resumo: | Background : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle. |
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Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).Cattle resistance tickBackground : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.MARCO ANTONIO MACHADO, CNPGL; ANA LUISA SOUSA AZEVEDO, CNPGL; ROBERTO LUIZ TEODORO, Pesquisador aposentado do CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE ELIZA FACIONI GUIMARÃES, UFV; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; GUSTAVO GASPARIN, CAPES/UFSCAR; RUI DA SILVA VERNEQUE, CNPGL.MACHADO, M. A.AZEVEDO, A. L. S.TEODORO, R. L.PIRES, M. de F. A.PEIXOTO, M. G. C. D.FREITAS, C. dePRATA, M. C. de A.FURLONG, J.SILVA, M. V. G. B.GUIMARÃES, S. E. F.REGITANO, L. C. de A.COUTINHO, L. L.GASPARIN, G.VERNEQUE, R. da S.2011-04-09T16:09:24Z2011-04-09T16:09:24Z2011-03-1620102011-04-10T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBMC Genomics, v. 11, article 280, 2010.http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086https://doi.org/10.1186/1471-2164-11-280enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-15T22:07:37Zoai:www.alice.cnptia.embrapa.br:doc/881086Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542017-08-15T22:07:37falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-15T22:07:37Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
title |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
spellingShingle |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). MACHADO, M. A. Cattle resistance tick |
title_short |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
title_full |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
title_fullStr |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
title_full_unstemmed |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
title_sort |
Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus). |
author |
MACHADO, M. A. |
author_facet |
MACHADO, M. A. AZEVEDO, A. L. S. TEODORO, R. L. PIRES, M. de F. A. PEIXOTO, M. G. C. D. FREITAS, C. de PRATA, M. C. de A. FURLONG, J. SILVA, M. V. G. B. GUIMARÃES, S. E. F. REGITANO, L. C. de A. COUTINHO, L. L. GASPARIN, G. VERNEQUE, R. da S. |
author_role |
author |
author2 |
AZEVEDO, A. L. S. TEODORO, R. L. PIRES, M. de F. A. PEIXOTO, M. G. C. D. FREITAS, C. de PRATA, M. C. de A. FURLONG, J. SILVA, M. V. G. B. GUIMARÃES, S. E. F. REGITANO, L. C. de A. COUTINHO, L. L. GASPARIN, G. VERNEQUE, R. da S. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
MARCO ANTONIO MACHADO, CNPGL; ANA LUISA SOUSA AZEVEDO, CNPGL; ROBERTO LUIZ TEODORO, Pesquisador aposentado do CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; SIMONE ELIZA FACIONI GUIMARÃES, UFV; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; LUIZ LEHMANN COUTINHO, ESALQ/USP; GUSTAVO GASPARIN, CAPES/UFSCAR; RUI DA SILVA VERNEQUE, CNPGL. |
dc.contributor.author.fl_str_mv |
MACHADO, M. A. AZEVEDO, A. L. S. TEODORO, R. L. PIRES, M. de F. A. PEIXOTO, M. G. C. D. FREITAS, C. de PRATA, M. C. de A. FURLONG, J. SILVA, M. V. G. B. GUIMARÃES, S. E. F. REGITANO, L. C. de A. COUTINHO, L. L. GASPARIN, G. VERNEQUE, R. da S. |
dc.subject.por.fl_str_mv |
Cattle resistance tick |
topic |
Cattle resistance tick |
description |
Background : In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) × Holstein (Bos taurus) cross. Results: Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23. Conclusions: The experimental F2 population derived from Gyr × Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2011-04-09T16:09:24Z 2011-04-09T16:09:24Z 2011-03-16 2011-04-10T11:11:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BMC Genomics, v. 11, article 280, 2010. http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086 https://doi.org/10.1186/1471-2164-11-280 |
identifier_str_mv |
BMC Genomics, v. 11, article 280, 2010. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/881086 https://doi.org/10.1186/1471-2164-11-280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503325325983744 |