Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.

Detalhes bibliográficos
Autor(a) principal: FERNANDEZ, J. H.
Data de Publicação: 2006
Outros Autores: RIOLI, V., NESHICH, G., FERRO, E. S., PORTARO, F. C., CAMARGO, A. C. M.
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/9292
Resumo: Short Abstract: Molecular modeling, combined with docking and molecular dynamics experiments was used to study the dynamics of catalysis/inhibition in ?druggable? human Oligopeptidases. The dynamics of ligand recognition and structural determinants for selective inhibition of these enzymes lead us to propose more selective oligopeptidase inhibitors with improved stability and pharmacological profile.
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spelling Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.Biologia molecularGenomaProteínaAnálise ComparativaMolecular biologyGenomeProteinsShort Abstract: Molecular modeling, combined with docking and molecular dynamics experiments was used to study the dynamics of catalysis/inhibition in ?druggable? human Oligopeptidases. The dynamics of ligand recognition and structural determinants for selective inhibition of these enzymes lead us to propose more selective oligopeptidase inhibitors with improved stability and pharmacological profile.ISMB, X-MEETING 2006. Poster E-8.JORGE H. FERNANDEZ, Instituto Butantan; VANESSA RIOLI, Instituto Butantan; GORAN NESHICH, CNPTIA; EMMER S. FERRO, USP; FERNANDA C. PORTARO, Instituto Butantan; ANTONIO C. M. CAMARGO, Instituto Butantan.FERNANDEZ, J. H.RIOLI, V.NESHICH, G.FERRO, E. S.PORTARO, F. C.CAMARGO, A. C. M.2022-05-17T18:13:18Z2022-05-17T18:13:18Z2006-08-172006Resumo em anais e proceedingsinfo:eu-repo/semantics/publishedVersionNão paginado.In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006.http://www.alice.cnptia.embrapa.br/alice/handle/doc/9292enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2022-05-17T18:13:26Zoai:www.alice.cnptia.embrapa.br:doc/9292Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542022-05-17T18:13:26Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
title Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
spellingShingle Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
FERNANDEZ, J. H.
Biologia molecular
Genoma
Proteína
Análise Comparativa
Molecular biology
Genome
Proteins
title_short Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
title_full Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
title_fullStr Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
title_full_unstemmed Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
title_sort Dynamics of catalysis and inhibition in oligopeptidases: natural peptide structures as promising antihypertensive agents.
author FERNANDEZ, J. H.
author_facet FERNANDEZ, J. H.
RIOLI, V.
NESHICH, G.
FERRO, E. S.
PORTARO, F. C.
CAMARGO, A. C. M.
author_role author
author2 RIOLI, V.
NESHICH, G.
FERRO, E. S.
PORTARO, F. C.
CAMARGO, A. C. M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv JORGE H. FERNANDEZ, Instituto Butantan; VANESSA RIOLI, Instituto Butantan; GORAN NESHICH, CNPTIA; EMMER S. FERRO, USP; FERNANDA C. PORTARO, Instituto Butantan; ANTONIO C. M. CAMARGO, Instituto Butantan.
dc.contributor.author.fl_str_mv FERNANDEZ, J. H.
RIOLI, V.
NESHICH, G.
FERRO, E. S.
PORTARO, F. C.
CAMARGO, A. C. M.
dc.subject.por.fl_str_mv Biologia molecular
Genoma
Proteína
Análise Comparativa
Molecular biology
Genome
Proteins
topic Biologia molecular
Genoma
Proteína
Análise Comparativa
Molecular biology
Genome
Proteins
description Short Abstract: Molecular modeling, combined with docking and molecular dynamics experiments was used to study the dynamics of catalysis/inhibition in ?druggable? human Oligopeptidases. The dynamics of ligand recognition and structural determinants for selective inhibition of these enzymes lead us to propose more selective oligopeptidase inhibitors with improved stability and pharmacological profile.
publishDate 2006
dc.date.none.fl_str_mv 2006-08-17
2006
2022-05-17T18:13:18Z
2022-05-17T18:13:18Z
dc.type.driver.fl_str_mv Resumo em anais e proceedings
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/9292
identifier_str_mv In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/9292
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv Não paginado.
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
_version_ 1817695637582381056

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