Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.

Detalhes bibliográficos
Autor(a) principal: RODRIGUES, I. A.
Data de Publicação: 2014
Outros Autores: AZEVEDO, M. M. B., CHAVES, F. C. M., ALVINO, C. S., ALVIANO, D. S., VERMELHO, A. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/984315
http://dx.doi.org/10.1155/2014/985171
Resumo: Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).
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spelling Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.Arrabidaea chicaCrajiruCurrently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).Igor A. Rodrigues, Universidade Federal do Rio de Janeiro; Mariana M. B. Azevedo, Programa de Pós-Graduação Ciências dos Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro; FRANCISCO CELIO MAIA CHAVES, CPAA; Celuta S. Alviano, Universidade Federal do Rio de Janeiro; Daniela S. Alviano, Universidade Federal do Rio de Janeiro; Alane B. Vermelho, Universidade Federal do Rio de Janeiro.RODRIGUES, I. A.AZEVEDO, M. M. B.CHAVES, F. C. M.ALVINO, C. S.ALVIANO, D. S.VERMELHO, A. B.2018-01-31T00:45:12Z2018-01-31T00:45:12Z2014-04-1020142018-01-31T00:45:12Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBioMed Research International, Article ID 985171, p. 1-7, 2014.http://www.alice.cnptia.embrapa.br/alice/handle/doc/984315http://dx.doi.org/10.1155/2014/985171enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2018-01-31T00:45:20Zoai:www.alice.cnptia.embrapa.br:doc/984315Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542018-01-31T00:45:20falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542018-01-31T00:45:20Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
title Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
spellingShingle Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
RODRIGUES, I. A.
Arrabidaea chica
Crajiru
title_short Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
title_full Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
title_fullStr Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
title_full_unstemmed Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
title_sort Arrabidaea chica hexanic extract induces mitochondrion damage and peptidase inhibition on Leishmania spp.
author RODRIGUES, I. A.
author_facet RODRIGUES, I. A.
AZEVEDO, M. M. B.
CHAVES, F. C. M.
ALVINO, C. S.
ALVIANO, D. S.
VERMELHO, A. B.
author_role author
author2 AZEVEDO, M. M. B.
CHAVES, F. C. M.
ALVINO, C. S.
ALVIANO, D. S.
VERMELHO, A. B.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Igor A. Rodrigues, Universidade Federal do Rio de Janeiro; Mariana M. B. Azevedo, Programa de Pós-Graduação Ciências dos Alimentos, Instituto de Química, Universidade Federal do Rio de Janeiro; FRANCISCO CELIO MAIA CHAVES, CPAA; Celuta S. Alviano, Universidade Federal do Rio de Janeiro; Daniela S. Alviano, Universidade Federal do Rio de Janeiro; Alane B. Vermelho, Universidade Federal do Rio de Janeiro.
dc.contributor.author.fl_str_mv RODRIGUES, I. A.
AZEVEDO, M. M. B.
CHAVES, F. C. M.
ALVINO, C. S.
ALVIANO, D. S.
VERMELHO, A. B.
dc.subject.por.fl_str_mv Arrabidaea chica
Crajiru
topic Arrabidaea chica
Crajiru
description Currently available leishmaniasis treatments are limited due to severe side effects. Arrabidaea chica is a medicinal plant used in Brazil against several diseases. In this study, we investigated the effects of 5 fractions obtained from the crude hexanic extract of A. chica against Leishmania amazonensis and L. infantum, as well as on the interaction of these parasites with host cells. Promastigotes were treated with several concentrations of the fractions obtained from A. chica for determination of their minimum inhibitory concentration (MIC).
publishDate 2014
dc.date.none.fl_str_mv 2014-04-10
2014
2018-01-31T00:45:12Z
2018-01-31T00:45:12Z
2018-01-31T00:45:12Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BioMed Research International, Article ID 985171, p. 1-7, 2014.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/984315
http://dx.doi.org/10.1155/2014/985171
identifier_str_mv BioMed Research International, Article ID 985171, p. 1-7, 2014.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/984315
http://dx.doi.org/10.1155/2014/985171
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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