Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.

Detalhes bibliográficos
Autor(a) principal: SANTOS, C. G. dos
Data de Publicação: 2022
Outros Autores: SOUSA, M. F., VIEIRA, J. I. G., MORAIS, L. R. de, FERNANDES, A. A. S., LITTIERE, T. de O., OTTO, P. I., MACHADO, M. A., SILVA, M. V. G. B., BONAFÉ, C. M., MAGALHÃES, A. F. B., VERARDO, L. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893
https://doi.org/10.1080/09712119.2022.2096035
Resumo: Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.
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spelling Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.EctoparasitaSistema imunológicoBovinoCarrapatoGenomaCarneHospedeiro AnimalRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.CASSIANE GOMES DOS SANTOS, Universidade Federal dos Vales do Jequitinhonha e MucuriMARIELE FREITAS SOUSA, Universidade Federal dos Vales do Jequitinhonha e MucuriJOÃO INÁCIO GOMES VIEIRA, Universidade Federal dos Vales do Jequitinhonha e MucuriLUANA RAFAELA DE MORAIS, Universidade Federal dos Vales do Jequitinhonha e MucuriALINE AUXILIADORA SILVA FERNANDES, Universidade Federal dos Vales do Jequitinhonha e MucuriTHAYSSA DE OLIVEIRA LITTIERE, Universidade Estadual Paulista "Júlio de Mesquita Filho"PAMELA ITAJARA OTTO, Universidade Federal de Santa MariaMARCO ANTONIO MACHADO, CNPGLMARCOS VINICIUS GUALBERTO B SILVA, CNPGLCRISTINA MOREIRA BONAFÉ, Universidade Federal dos Vales do Jequitinhonha e MucuriANA FABRÍCIA BRAGA MAGALHÃES, Universidade Federal dos Vales do Jequitinhonha e MucuriLUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri.SANTOS, C. G. dosSOUSA, M. F.VIEIRA, J. I. G.MORAIS, L. R. deFERNANDES, A. A. S.LITTIERE, T. de O.OTTO, P. I.MACHADO, M. A.SILVA, M. V. G. B.BONAFÉ, C. M.MAGALHÃES, A. F. B.VERARDO, L. L.2022-07-25T13:20:05Z2022-07-25T13:20:05Z2022-07-252022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJournal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893https://doi.org/10.1080/09712119.2022.2096035enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2022-07-25T13:20:13Zoai:www.alice.cnptia.embrapa.br:doc/1144893Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542022-07-25T13:20:13falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542022-07-25T13:20:13Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
title Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
spellingShingle Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
SANTOS, C. G. dos
Ectoparasita
Sistema imunológico
Bovino
Carrapato
Genoma
Carne
Hospedeiro Animal
title_short Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
title_full Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
title_fullStr Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
title_full_unstemmed Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
title_sort Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
author SANTOS, C. G. dos
author_facet SANTOS, C. G. dos
SOUSA, M. F.
VIEIRA, J. I. G.
MORAIS, L. R. de
FERNANDES, A. A. S.
LITTIERE, T. de O.
OTTO, P. I.
MACHADO, M. A.
SILVA, M. V. G. B.
BONAFÉ, C. M.
MAGALHÃES, A. F. B.
VERARDO, L. L.
author_role author
author2 SOUSA, M. F.
VIEIRA, J. I. G.
MORAIS, L. R. de
FERNANDES, A. A. S.
LITTIERE, T. de O.
OTTO, P. I.
MACHADO, M. A.
SILVA, M. V. G. B.
BONAFÉ, C. M.
MAGALHÃES, A. F. B.
VERARDO, L. L.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv CASSIANE GOMES DOS SANTOS, Universidade Federal dos Vales do Jequitinhonha e Mucuri
MARIELE FREITAS SOUSA, Universidade Federal dos Vales do Jequitinhonha e Mucuri
JOÃO INÁCIO GOMES VIEIRA, Universidade Federal dos Vales do Jequitinhonha e Mucuri
LUANA RAFAELA DE MORAIS, Universidade Federal dos Vales do Jequitinhonha e Mucuri
ALINE AUXILIADORA SILVA FERNANDES, Universidade Federal dos Vales do Jequitinhonha e Mucuri
THAYSSA DE OLIVEIRA LITTIERE, Universidade Estadual Paulista "Júlio de Mesquita Filho"
PAMELA ITAJARA OTTO, Universidade Federal de Santa Maria
MARCO ANTONIO MACHADO, CNPGL
MARCOS VINICIUS GUALBERTO B SILVA, CNPGL
CRISTINA MOREIRA BONAFÉ, Universidade Federal dos Vales do Jequitinhonha e Mucuri
ANA FABRÍCIA BRAGA MAGALHÃES, Universidade Federal dos Vales do Jequitinhonha e Mucuri
LUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri.
dc.contributor.author.fl_str_mv SANTOS, C. G. dos
SOUSA, M. F.
VIEIRA, J. I. G.
MORAIS, L. R. de
FERNANDES, A. A. S.
LITTIERE, T. de O.
OTTO, P. I.
MACHADO, M. A.
SILVA, M. V. G. B.
BONAFÉ, C. M.
MAGALHÃES, A. F. B.
VERARDO, L. L.
dc.subject.por.fl_str_mv Ectoparasita
Sistema imunológico
Bovino
Carrapato
Genoma
Carne
Hospedeiro Animal
topic Ectoparasita
Sistema imunológico
Bovino
Carrapato
Genoma
Carne
Hospedeiro Animal
description Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-25T13:20:05Z
2022-07-25T13:20:05Z
2022-07-25
2022
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893
https://doi.org/10.1080/09712119.2022.2096035
identifier_str_mv Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893
https://doi.org/10.1080/09712119.2022.2096035
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
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reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
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repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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