Identification of genomic regions associated with backfat thickness in synthetic cattle.

Detalhes bibliográficos
Autor(a) principal: VERONESI, G. B.
Data de Publicação: 2010
Outros Autores: MEIRELLES, S. L., SANTIAGO, A. C., GROSSI, D. A., SONSTEGARD, T. S., YAMAGISHI, M. E. B., COUTINHO, L. L., OLIVEIRA, H. N., ALENCAR, M. M., REGITANO, L. C. de A.
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/876696
Resumo: Canchim is a synthetic beef cattle developed in Brazil which have good growth potential and tropical adaptation but suboptimal fat deposition. There are genomic regions associated with fat deposition already described, among them the centromeric region of BTA14. The scope of this work was to identify genomic regions associated with backfat thickness in Canchim (5/8 Charolais + 3/8 zebu) and MA (offspring of Charolais bulls and 1/2 Canchim + 1/2 Zebu cows) populations and to validate the association of haplotypes of the BTA14 with backfat thickness in this population. Thirty animals with extreme phenotypes were genotyped with the 54 K SNP chip, revealing 100 signifi cant SNPs contained in chromosomes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 17, 18, 19, 20, 21, 23, 24, 27, 28 and X. Thirty-four SNPs constituted seven chromosomal regions containing 3 or more SNPs located at intervals shorter than 9 Mb and, among these, ten SNPs in BTA 14 were selected for validation. Genotyping in the population was performed by the TaqMan method in families comprising more than 10 individuals with backfat thickness information at the age of 18 months (644 animals). Validation of the BTA14 SNPs revealed two haplotypes, one in the centromeric region and another in the middle region of BTA14, signifi cantly associated with fat thickness, both with additive effects on backfat thickness. Genes located close to these two regions should be further studied to identify potential mutations involved in backfat deposition.
id EMBR_34936bf3069c74f1adfef72ca3a8d2c5
oai_identifier_str oai:www.alice.cnptia.embrapa.br:doc/876696
network_acronym_str EMBR
network_name_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository_id_str 2154
spelling Identification of genomic regions associated with backfat thickness in synthetic cattle.CanchimGenômicaGado de CorteBeef cattleGenomicsCanchim is a synthetic beef cattle developed in Brazil which have good growth potential and tropical adaptation but suboptimal fat deposition. There are genomic regions associated with fat deposition already described, among them the centromeric region of BTA14. The scope of this work was to identify genomic regions associated with backfat thickness in Canchim (5/8 Charolais + 3/8 zebu) and MA (offspring of Charolais bulls and 1/2 Canchim + 1/2 Zebu cows) populations and to validate the association of haplotypes of the BTA14 with backfat thickness in this population. Thirty animals with extreme phenotypes were genotyped with the 54 K SNP chip, revealing 100 signifi cant SNPs contained in chromosomes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 17, 18, 19, 20, 21, 23, 24, 27, 28 and X. Thirty-four SNPs constituted seven chromosomal regions containing 3 or more SNPs located at intervals shorter than 9 Mb and, among these, ten SNPs in BTA 14 were selected for validation. Genotyping in the population was performed by the TaqMan method in families comprising more than 10 individuals with backfat thickness information at the age of 18 months (644 animals). Validation of the BTA14 SNPs revealed two haplotypes, one in the centromeric region and another in the middle region of BTA14, signifi cantly associated with fat thickness, both with additive effects on backfat thickness. Genes located close to these two regions should be further studied to identify potential mutations involved in backfat deposition.P4020.GISELE B. VERONESI, UFSCar; SARAH L. MEIRELLES, UFSCar; ADELITA C. SANTIAGO, UFSCar; DANIELA A. GROSSI, UNESP; TAD S. SONSTEGARD, United States Department of Agriculture; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; LUIZ L. COUTINHO, ESALQ/USP; HENRIQUE N. OLIVEIRA, UNESP; MAURICIO MELLO ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.VERONESI, G. B.MEIRELLES, S. L.SANTIAGO, A. C.GROSSI, D. A.SONSTEGARD, T. S.YAMAGISHI, M. E. B.COUTINHO, L. L.OLIVEIRA, H. N.ALENCAR, M. M.REGITANO, L. C. de A.2011-07-26T01:04:06Z2011-07-26T01:04:06Z2011-02-1020102020-01-24T11:11:11ZResumo em anais e proceedingsinfo:eu-repo/semantics/publishedVersionIn: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010.http://www.alice.cnptia.embrapa.br/alice/handle/doc/876696enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-15T22:23:25Zoai:www.alice.cnptia.embrapa.br:doc/876696Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-15T22:23:25Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Identification of genomic regions associated with backfat thickness in synthetic cattle.
title Identification of genomic regions associated with backfat thickness in synthetic cattle.
spellingShingle Identification of genomic regions associated with backfat thickness in synthetic cattle.
VERONESI, G. B.
Canchim
Genômica
Gado de Corte
Beef cattle
Genomics
title_short Identification of genomic regions associated with backfat thickness in synthetic cattle.
title_full Identification of genomic regions associated with backfat thickness in synthetic cattle.
title_fullStr Identification of genomic regions associated with backfat thickness in synthetic cattle.
title_full_unstemmed Identification of genomic regions associated with backfat thickness in synthetic cattle.
title_sort Identification of genomic regions associated with backfat thickness in synthetic cattle.
author VERONESI, G. B.
author_facet VERONESI, G. B.
MEIRELLES, S. L.
SANTIAGO, A. C.
GROSSI, D. A.
SONSTEGARD, T. S.
YAMAGISHI, M. E. B.
COUTINHO, L. L.
OLIVEIRA, H. N.
ALENCAR, M. M.
REGITANO, L. C. de A.
author_role author
author2 MEIRELLES, S. L.
SANTIAGO, A. C.
GROSSI, D. A.
SONSTEGARD, T. S.
YAMAGISHI, M. E. B.
COUTINHO, L. L.
OLIVEIRA, H. N.
ALENCAR, M. M.
REGITANO, L. C. de A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv GISELE B. VERONESI, UFSCar; SARAH L. MEIRELLES, UFSCar; ADELITA C. SANTIAGO, UFSCar; DANIELA A. GROSSI, UNESP; TAD S. SONSTEGARD, United States Department of Agriculture; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; LUIZ L. COUTINHO, ESALQ/USP; HENRIQUE N. OLIVEIRA, UNESP; MAURICIO MELLO ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
dc.contributor.author.fl_str_mv VERONESI, G. B.
MEIRELLES, S. L.
SANTIAGO, A. C.
GROSSI, D. A.
SONSTEGARD, T. S.
YAMAGISHI, M. E. B.
COUTINHO, L. L.
OLIVEIRA, H. N.
ALENCAR, M. M.
REGITANO, L. C. de A.
dc.subject.por.fl_str_mv Canchim
Genômica
Gado de Corte
Beef cattle
Genomics
topic Canchim
Genômica
Gado de Corte
Beef cattle
Genomics
description Canchim is a synthetic beef cattle developed in Brazil which have good growth potential and tropical adaptation but suboptimal fat deposition. There are genomic regions associated with fat deposition already described, among them the centromeric region of BTA14. The scope of this work was to identify genomic regions associated with backfat thickness in Canchim (5/8 Charolais + 3/8 zebu) and MA (offspring of Charolais bulls and 1/2 Canchim + 1/2 Zebu cows) populations and to validate the association of haplotypes of the BTA14 with backfat thickness in this population. Thirty animals with extreme phenotypes were genotyped with the 54 K SNP chip, revealing 100 signifi cant SNPs contained in chromosomes 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 17, 18, 19, 20, 21, 23, 24, 27, 28 and X. Thirty-four SNPs constituted seven chromosomal regions containing 3 or more SNPs located at intervals shorter than 9 Mb and, among these, ten SNPs in BTA 14 were selected for validation. Genotyping in the population was performed by the TaqMan method in families comprising more than 10 individuals with backfat thickness information at the age of 18 months (644 animals). Validation of the BTA14 SNPs revealed two haplotypes, one in the centromeric region and another in the middle region of BTA14, signifi cantly associated with fat thickness, both with additive effects on backfat thickness. Genes located close to these two regions should be further studied to identify potential mutations involved in backfat deposition.
publishDate 2010
dc.date.none.fl_str_mv 2010
2011-07-26T01:04:06Z
2011-07-26T01:04:06Z
2011-02-10
2020-01-24T11:11:11Z
dc.type.driver.fl_str_mv Resumo em anais e proceedings
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv In: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/876696
identifier_str_mv In: INTERNATIONAL CONFERENCE ON ANIMAL GENETICS, 32., 2010, Edinburgh. Proceedings... Edinburgh: International Society for Animal Genetics, 2010.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/876696
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
_version_ 1817695191427973120