An Ag-dependent approach based on adaptive mechanisms for investigating the regulation of the memory B cell reservoir.

• Autor(a) principal: CASTRO, A. de
• Data de Publicação: 2012
• Tipo de documento: Capítulo de livro
• Idioma: eng
• Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
• Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/924382
• topic: Modelo dinâmico; Simulação dinâmica; Células B; Modelo Matemático; Modelo de Simulação; Dynamic models; Simulation models; Mathematical models

In fact, it is well-known that the soluble antibody population is one of the essential mechanisms of immunological response regulation [23-25]. However, despite the pioneering work of Lagreca et al. (2001) in developing a coupled map for studying the behavior of the mammalian immune system, their model did not consider these populations [1-6], which makes the model incomplete with respect to the regulation of the immune response by adaptive mechanisms. This omission opens up the possibility of extending their work by taking the soluble antibody populations into account. We have performed that work and present our immunological modeling and simulation findings in this paper.