Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle.
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144851 https://doi.org/10.1016/j.ygeno.2022.110423 |
Resumo: | Background - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle. |
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Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle.Adaptação ao desertoZebu africanoZebu sudanêsGado ZebuInsulinaMetabolismo AnimalBackground - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle.ABDULFATAI TIJJANI, International Livestock Research Institute - ILRI; BASHIR SALIM, University of Khartoum; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; HAMZA A. ELTAHIR, University of Nyala; TAHA H. MUSA, Darfur College; KAREN MARSHALL, International Livestock Research Institute - ILRI; OLIVIER HANOTTE, International Livestock Research Institute - ILRI; HASSAN H. MUSA, University of Nyala.TIJJANI, A.SALIM, B.SILVA, M. V. G. B.ELTAHIR, H. A.MUSA, T. H.MARSHALL, K.HANOTTE, O.MUSA, H. H.2022-07-21T16:19:50Z2022-07-21T16:19:50Z2022-07-212022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGenomics, v. 114, 110423, 2022.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144851https://doi.org/10.1016/j.ygeno.2022.110423enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2022-07-21T16:20:00Zoai:www.alice.cnptia.embrapa.br:doc/1144851Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542022-07-21T16:20falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542022-07-21T16:20Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
title |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
spellingShingle |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. TIJJANI, A. Adaptação ao deserto Zebu africano Zebu sudanês Gado Zebu Insulina Metabolismo Animal |
title_short |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
title_full |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
title_fullStr |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
title_full_unstemmed |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
title_sort |
Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. |
author |
TIJJANI, A. |
author_facet |
TIJJANI, A. SALIM, B. SILVA, M. V. G. B. ELTAHIR, H. A. MUSA, T. H. MARSHALL, K. HANOTTE, O. MUSA, H. H. |
author_role |
author |
author2 |
SALIM, B. SILVA, M. V. G. B. ELTAHIR, H. A. MUSA, T. H. MARSHALL, K. HANOTTE, O. MUSA, H. H. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
ABDULFATAI TIJJANI, International Livestock Research Institute - ILRI; BASHIR SALIM, University of Khartoum; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; HAMZA A. ELTAHIR, University of Nyala; TAHA H. MUSA, Darfur College; KAREN MARSHALL, International Livestock Research Institute - ILRI; OLIVIER HANOTTE, International Livestock Research Institute - ILRI; HASSAN H. MUSA, University of Nyala. |
dc.contributor.author.fl_str_mv |
TIJJANI, A. SALIM, B. SILVA, M. V. G. B. ELTAHIR, H. A. MUSA, T. H. MARSHALL, K. HANOTTE, O. MUSA, H. H. |
dc.subject.por.fl_str_mv |
Adaptação ao deserto Zebu africano Zebu sudanês Gado Zebu Insulina Metabolismo Animal |
topic |
Adaptação ao deserto Zebu africano Zebu sudanês Gado Zebu Insulina Metabolismo Animal |
description |
Background - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-21T16:19:50Z 2022-07-21T16:19:50Z 2022-07-21 2022 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Genomics, v. 114, 110423, 2022. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144851 https://doi.org/10.1016/j.ygeno.2022.110423 |
identifier_str_mv |
Genomics, v. 114, 110423, 2022. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144851 https://doi.org/10.1016/j.ygeno.2022.110423 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503526657818624 |