GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

Detalhes bibliográficos
Autor(a) principal: GUEDES, J. A. C.
Data de Publicação: 2020
Outros Autores: ALVES FILHO, E. DE G., SILVA, M. F. S., RODRIGUES, T. H. S., RAMIRES, C. M. C., LIMA, M. A. C. de, SILVA, G. S. DA, PESSOA, C. DO Ó, CANUTO, K. M., BRITO, E. S. de, ALVES, R. E., NASCIMENTO, R. F. DO, ZOCOLO, G. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219
Resumo: Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds
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spelling GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.MetabolômicaResiduo agroindustrialAgroindustriaCo-produtoSpondias MombinUmbuCromatografiaYellow mombinsChromatographyMetabolomicsSpondiasAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compoundsJHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do CearáELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria TropicalMARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do CearáTIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, SobralCHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA)MARIA AUXILIADORA COELHO DE LIMA, CPATSAGISELE SILVESTRE DA SILVA, Embrapa Agroindústria TropicalCLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do CearáKIRLEY MARQUES CANUTO, CNPATEDY SOUSA DE BRITO, CNPATRICARDO ELESBAO ALVES, CNATRONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do CearáGUILHERME JULIAO ZOCOLO, CNPAT.GUEDES, J. A. C.ALVES FILHO, E. DE G.SILVA, M. F. S.RODRIGUES, T. H. S.RAMIRES, C. M. C.LIMA, M. A. C. deSILVA, G. S. DAPESSOA, C. DO ÓCANUTO, K. M.BRITO, E. S. deALVES, R. E.NASCIMENTO, R. F. DOZOCOLO, G. J.2020-02-13T18:16:16Z2020-02-13T18:16:16Z2020-02-1320202020-04-17T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlep. 331-340Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.http://www.alice.cnptia.embrapa.br/alice/handle/doc/112021910.21577/0103-5053.20190185enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2020-02-13T18:16:22Zoai:www.alice.cnptia.embrapa.br:doc/1120219Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542020-02-13T18:16:22Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
title GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
spellingShingle GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
GUEDES, J. A. C.
Metabolômica
Residuo agroindustrial
Agroindustria
Co-produto
Spondias Mombin
Umbu
Cromatografia
Yellow mombins
Chromatography
Metabolomics
Spondias
title_short GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
title_full GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
title_fullStr GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
title_full_unstemmed GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
title_sort GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
author GUEDES, J. A. C.
author_facet GUEDES, J. A. C.
ALVES FILHO, E. DE G.
SILVA, M. F. S.
RODRIGUES, T. H. S.
RAMIRES, C. M. C.
LIMA, M. A. C. de
SILVA, G. S. DA
PESSOA, C. DO Ó
CANUTO, K. M.
BRITO, E. S. de
ALVES, R. E.
NASCIMENTO, R. F. DO
ZOCOLO, G. J.
author_role author
author2 ALVES FILHO, E. DE G.
SILVA, M. F. S.
RODRIGUES, T. H. S.
RAMIRES, C. M. C.
LIMA, M. A. C. de
SILVA, G. S. DA
PESSOA, C. DO Ó
CANUTO, K. M.
BRITO, E. S. de
ALVES, R. E.
NASCIMENTO, R. F. DO
ZOCOLO, G. J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará
ELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropical
MARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará
TIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobral
CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA)
MARIA AUXILIADORA COELHO DE LIMA, CPATSA
GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical
CLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará
KIRLEY MARQUES CANUTO, CNPAT
EDY SOUSA DE BRITO, CNPAT
RICARDO ELESBAO ALVES, CNAT
RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará
GUILHERME JULIAO ZOCOLO, CNPAT.
dc.contributor.author.fl_str_mv GUEDES, J. A. C.
ALVES FILHO, E. DE G.
SILVA, M. F. S.
RODRIGUES, T. H. S.
RAMIRES, C. M. C.
LIMA, M. A. C. de
SILVA, G. S. DA
PESSOA, C. DO Ó
CANUTO, K. M.
BRITO, E. S. de
ALVES, R. E.
NASCIMENTO, R. F. DO
ZOCOLO, G. J.
dc.subject.por.fl_str_mv Metabolômica
Residuo agroindustrial
Agroindustria
Co-produto
Spondias Mombin
Umbu
Cromatografia
Yellow mombins
Chromatography
Metabolomics
Spondias
topic Metabolômica
Residuo agroindustrial
Agroindustria
Co-produto
Spondias Mombin
Umbu
Cromatografia
Yellow mombins
Chromatography
Metabolomics
Spondias
description Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds
publishDate 2020
dc.date.none.fl_str_mv 2020-02-13T18:16:16Z
2020-02-13T18:16:16Z
2020-02-13
2020
2020-04-17T11:11:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219
10.21577/0103-5053.20190185
identifier_str_mv Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.
10.21577/0103-5053.20190185
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv p. 331-340
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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