GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219 |
Resumo: | Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds |
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GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.MetabolômicaResiduo agroindustrialAgroindustriaCo-produtoSpondias MombinUmbuCromatografiaYellow mombinsChromatographyMetabolomicsSpondiasAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compoundsJHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do CearáELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria TropicalMARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do CearáTIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, SobralCHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA)MARIA AUXILIADORA COELHO DE LIMA, CPATSAGISELE SILVESTRE DA SILVA, Embrapa Agroindústria TropicalCLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do CearáKIRLEY MARQUES CANUTO, CNPATEDY SOUSA DE BRITO, CNPATRICARDO ELESBAO ALVES, CNATRONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do CearáGUILHERME JULIAO ZOCOLO, CNPAT.GUEDES, J. A. C.ALVES FILHO, E. DE G.SILVA, M. F. S.RODRIGUES, T. H. S.RAMIRES, C. M. C.LIMA, M. A. C. deSILVA, G. S. DAPESSOA, C. DO ÓCANUTO, K. M.BRITO, E. S. deALVES, R. E.NASCIMENTO, R. F. DOZOCOLO, G. J.2020-02-13T18:16:16Z2020-02-13T18:16:16Z2020-02-1320202020-04-17T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlep. 331-340Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.http://www.alice.cnptia.embrapa.br/alice/handle/doc/112021910.21577/0103-5053.20190185enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2020-02-13T18:16:22Zoai:www.alice.cnptia.embrapa.br:doc/1120219Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542020-02-13T18:16:22Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
title |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
spellingShingle |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. GUEDES, J. A. C. Metabolômica Residuo agroindustrial Agroindustria Co-produto Spondias Mombin Umbu Cromatografia Yellow mombins Chromatography Metabolomics Spondias |
title_short |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
title_full |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
title_fullStr |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
title_full_unstemmed |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
title_sort |
GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. |
author |
GUEDES, J. A. C. |
author_facet |
GUEDES, J. A. C. ALVES FILHO, E. DE G. SILVA, M. F. S. RODRIGUES, T. H. S. RAMIRES, C. M. C. LIMA, M. A. C. de SILVA, G. S. DA PESSOA, C. DO Ó CANUTO, K. M. BRITO, E. S. de ALVES, R. E. NASCIMENTO, R. F. DO ZOCOLO, G. J. |
author_role |
author |
author2 |
ALVES FILHO, E. DE G. SILVA, M. F. S. RODRIGUES, T. H. S. RAMIRES, C. M. C. LIMA, M. A. C. de SILVA, G. S. DA PESSOA, C. DO Ó CANUTO, K. M. BRITO, E. S. de ALVES, R. E. NASCIMENTO, R. F. DO ZOCOLO, G. J. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará ELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropical MARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará TIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobral CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA) MARIA AUXILIADORA COELHO DE LIMA, CPATSA GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical CLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará KIRLEY MARQUES CANUTO, CNPAT EDY SOUSA DE BRITO, CNPAT RICARDO ELESBAO ALVES, CNAT RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará GUILHERME JULIAO ZOCOLO, CNPAT. |
dc.contributor.author.fl_str_mv |
GUEDES, J. A. C. ALVES FILHO, E. DE G. SILVA, M. F. S. RODRIGUES, T. H. S. RAMIRES, C. M. C. LIMA, M. A. C. de SILVA, G. S. DA PESSOA, C. DO Ó CANUTO, K. M. BRITO, E. S. de ALVES, R. E. NASCIMENTO, R. F. DO ZOCOLO, G. J. |
dc.subject.por.fl_str_mv |
Metabolômica Residuo agroindustrial Agroindustria Co-produto Spondias Mombin Umbu Cromatografia Yellow mombins Chromatography Metabolomics Spondias |
topic |
Metabolômica Residuo agroindustrial Agroindustria Co-produto Spondias Mombin Umbu Cromatografia Yellow mombins Chromatography Metabolomics Spondias |
description |
Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-02-13T18:16:16Z 2020-02-13T18:16:16Z 2020-02-13 2020 2020-04-17T11:11:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219 10.21577/0103-5053.20190185 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020. 10.21577/0103-5053.20190185 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
p. 331-340 |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1817695586815574016 |