A comprehensive manually-curated compendium of bovine transcription factors.

• Autor(a) principal: SOUZA, M. M. de
• Data de Publicação: 2018
• Outros Autores: ZERLOTINI NETO, A., GEISTLINGER, L., TIZIOTO, P. C., TAYLOR, J. F., ROCHA, M. I. P., DINIZ, W. J. S., COUTINHO, L. L., REGITANO, L. C. de A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
• Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1102174
• topic: DNA bovino; Expressão gênica; Gene expression in cattle; Gene expression regulation

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.