Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.

Detalhes bibliográficos
Autor(a) principal: OTENIO, C. C. M.
Data de Publicação: 2012
Outros Autores: FONSECA, I., MARTINS, M. F., RIBEIRO, L. C., ASSIS, N. M. S. P., FERREIRA, A. P., RIBEIRO, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391
https://doi.org/10.4238/2012.september.20.3
Resumo: Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.
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spelling Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.GengivaPeriodontoPeriodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.C. C. M. OTENIO, UFJF; I. FONSECA, UFV; MARTA FONSECA MARTINS, CNPGL; L. C. RIBEIRO, UFV; N. M. S. P. ASSIS, UFJF; A. P. FERREIRA, UFJF; R. A. RIBEIRO, UFJF.OTENIO, C. C. M.FONSECA, I.MARTINS, M. F.RIBEIRO, L. C.ASSIS, N. M. S. P.FERREIRA, A. P.RIBEIRO, R. A.2024-02-08T11:32:23Z2024-02-08T11:32:23Z2013-02-052012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGenetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012.http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391https://doi.org/10.4238/2012.september.20.3enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2024-02-08T11:32:23Zoai:www.alice.cnptia.embrapa.br:doc/948391Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542024-02-08T11:32:23falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542024-02-08T11:32:23Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
title Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
spellingShingle Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
OTENIO, C. C. M.
Gengiva
Periodonto
title_short Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
title_full Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
title_fullStr Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
title_full_unstemmed Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
title_sort Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
author OTENIO, C. C. M.
author_facet OTENIO, C. C. M.
FONSECA, I.
MARTINS, M. F.
RIBEIRO, L. C.
ASSIS, N. M. S. P.
FERREIRA, A. P.
RIBEIRO, R. A.
author_role author
author2 FONSECA, I.
MARTINS, M. F.
RIBEIRO, L. C.
ASSIS, N. M. S. P.
FERREIRA, A. P.
RIBEIRO, R. A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv C. C. M. OTENIO, UFJF; I. FONSECA, UFV; MARTA FONSECA MARTINS, CNPGL; L. C. RIBEIRO, UFV; N. M. S. P. ASSIS, UFJF; A. P. FERREIRA, UFJF; R. A. RIBEIRO, UFJF.
dc.contributor.author.fl_str_mv OTENIO, C. C. M.
FONSECA, I.
MARTINS, M. F.
RIBEIRO, L. C.
ASSIS, N. M. S. P.
FERREIRA, A. P.
RIBEIRO, R. A.
dc.subject.por.fl_str_mv Gengiva
Periodonto
topic Gengiva
Periodonto
description Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.
publishDate 2012
dc.date.none.fl_str_mv 2012
2013-02-05
2024-02-08T11:32:23Z
2024-02-08T11:32:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Genetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391
https://doi.org/10.4238/2012.september.20.3
identifier_str_mv Genetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391
https://doi.org/10.4238/2012.september.20.3
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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