Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391 https://doi.org/10.4238/2012.september.20.3 |
Resumo: | Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy. |
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Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease.GengivaPeriodontoPeriodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.C. C. M. OTENIO, UFJF; I. FONSECA, UFV; MARTA FONSECA MARTINS, CNPGL; L. C. RIBEIRO, UFV; N. M. S. P. ASSIS, UFJF; A. P. FERREIRA, UFJF; R. A. RIBEIRO, UFJF.OTENIO, C. C. M.FONSECA, I.MARTINS, M. F.RIBEIRO, L. C.ASSIS, N. M. S. P.FERREIRA, A. P.RIBEIRO, R. A.2024-02-08T11:32:23Z2024-02-08T11:32:23Z2013-02-052012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGenetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012.http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391https://doi.org/10.4238/2012.september.20.3enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2024-02-08T11:32:23Zoai:www.alice.cnptia.embrapa.br:doc/948391Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542024-02-08T11:32:23falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542024-02-08T11:32:23Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
title |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
spellingShingle |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. OTENIO, C. C. M. Gengiva Periodonto |
title_short |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
title_full |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
title_fullStr |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
title_full_unstemmed |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
title_sort |
Expression of IL-1B, IL-6, TNF-a and iNOS in pregnant women with periodontal disease. |
author |
OTENIO, C. C. M. |
author_facet |
OTENIO, C. C. M. FONSECA, I. MARTINS, M. F. RIBEIRO, L. C. ASSIS, N. M. S. P. FERREIRA, A. P. RIBEIRO, R. A. |
author_role |
author |
author2 |
FONSECA, I. MARTINS, M. F. RIBEIRO, L. C. ASSIS, N. M. S. P. FERREIRA, A. P. RIBEIRO, R. A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
C. C. M. OTENIO, UFJF; I. FONSECA, UFV; MARTA FONSECA MARTINS, CNPGL; L. C. RIBEIRO, UFV; N. M. S. P. ASSIS, UFJF; A. P. FERREIRA, UFJF; R. A. RIBEIRO, UFJF. |
dc.contributor.author.fl_str_mv |
OTENIO, C. C. M. FONSECA, I. MARTINS, M. F. RIBEIRO, L. C. ASSIS, N. M. S. P. FERREIRA, A. P. RIBEIRO, R. A. |
dc.subject.por.fl_str_mv |
Gengiva Periodonto |
topic |
Gengiva Periodonto |
description |
Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in comparison with non-pregnant women with and without periodontal disease since studies have suggested a relationship between periodontitis and the expression levels of these genes. The women in the sample were distributed into four groups: pregnant and non-pregnant women, with or without periodontal disease, a total of 32 women. The periodontal condition was evaluated according to the probing depth, clinical attachment level and bleeding on probing. Analysis of gene expression was performed by real-time PCR. Comparisons were made of the level of gene expression among the four groups. Expression of IL-1β in the non-pregnant women with periodontal disease was 12.6 times higher than in the non-pregnant women without periodontal disease (P < 0.01), while expression of TNF-α in the non-pregnant women without periodontal disease was 3.5 times higher than in the pregnant women with periodontal disease (P < 0.05). Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2013-02-05 2024-02-08T11:32:23Z 2024-02-08T11:32:23Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Genetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012. http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391 https://doi.org/10.4238/2012.september.20.3 |
identifier_str_mv |
Genetics and Molecular Research, v. 11, n. 4, p. 4468-4478, 2012. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/948391 https://doi.org/10.4238/2012.september.20.3 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
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Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
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EMBRAPA |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503558004998144 |