Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.

Detalhes bibliográficos
Autor(a) principal: PETRÔNIO, M. S.
Data de Publicação: 2021
Outros Autores: BARROS-ALEXANDRINO, T. T., LIMA, A. M. F., ASSIS, O. B. G. de, INOUE-NAGATA, A. K., NAKASU, E. Y. T., TIERA, M. J., PILON, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285
https://doi.org/10.33263/BRIAC124.52665279
Resumo: Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.
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spelling Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.Tomato mosaic virusDouble-stranded RNALettuceRNA interferenceThus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.MAICON S. PETRÔNIO, UNESPTAIS T. BARROS-ALEXANDRINOALINE M. F. LIMA, UNESPODILIO BENEDITO GARRIDO DE ASSIS, CNPDIAALICE KAZUKO INOUE NAGATA, CNPHERICH YUKIO TEMPEL NAKASU, CNPHMARCIO J. TIERA, UNESPLUCIMEIRE PILON, CNPH.PETRÔNIO, M. S.BARROS-ALEXANDRINO, T. T.LIMA, A. M. F.ASSIS, O. B. G. deINOUE-NAGATA, A. K.NAKASU, E. Y. T.TIERA, M. J.PILON, L.2021-11-18T15:01:13Z2021-11-18T15:01:13Z2021-11-182022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBiointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022.2069-5837http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285https://doi.org/10.33263/BRIAC124.52665279enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2021-11-18T15:01:22Zoai:www.alice.cnptia.embrapa.br:doc/1136285Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542021-11-18T15:01:22falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542021-11-18T15:01:22Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
spellingShingle Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
PETRÔNIO, M. S.
Tomato mosaic virus
Double-stranded RNA
Lettuce
RNA interference
title_short Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_full Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_fullStr Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_full_unstemmed Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
title_sort Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
author PETRÔNIO, M. S.
author_facet PETRÔNIO, M. S.
BARROS-ALEXANDRINO, T. T.
LIMA, A. M. F.
ASSIS, O. B. G. de
INOUE-NAGATA, A. K.
NAKASU, E. Y. T.
TIERA, M. J.
PILON, L.
author_role author
author2 BARROS-ALEXANDRINO, T. T.
LIMA, A. M. F.
ASSIS, O. B. G. de
INOUE-NAGATA, A. K.
NAKASU, E. Y. T.
TIERA, M. J.
PILON, L.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv MAICON S. PETRÔNIO, UNESP
TAIS T. BARROS-ALEXANDRINO
ALINE M. F. LIMA, UNESP
ODILIO BENEDITO GARRIDO DE ASSIS, CNPDIA
ALICE KAZUKO INOUE NAGATA, CNPH
ERICH YUKIO TEMPEL NAKASU, CNPH
MARCIO J. TIERA, UNESP
LUCIMEIRE PILON, CNPH.
dc.contributor.author.fl_str_mv PETRÔNIO, M. S.
BARROS-ALEXANDRINO, T. T.
LIMA, A. M. F.
ASSIS, O. B. G. de
INOUE-NAGATA, A. K.
NAKASU, E. Y. T.
TIERA, M. J.
PILON, L.
dc.subject.por.fl_str_mv Tomato mosaic virus
Double-stranded RNA
Lettuce
RNA interference
topic Tomato mosaic virus
Double-stranded RNA
Lettuce
RNA interference
description Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-18T15:01:13Z
2021-11-18T15:01:13Z
2021-11-18
2022
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Biointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022.
2069-5837
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285
https://doi.org/10.33263/BRIAC124.52665279
identifier_str_mv Biointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022.
2069-5837
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136285
https://doi.org/10.33263/BRIAC124.52665279
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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