Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1146721 https://doi.org/10.1016/j.heliyon.2020.e05820 |
Resumo: | The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. |
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Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.PeixeCorydorasIvermectinThe FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies.RAFAEL R. M. MADRID, UNIVERSIDADE FEDERAL DE SÃO PAULO; PATRICK D. MATHEWS, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANA C. M. F. PATTA, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANAI P. GONZALES-FLORES, INSTITUTE OF RESEARCH OF THE PERUVIAN AMAZON; CARLOS A. B. RAMIREZ, UNIVERSIDADE FEDERAL DE SÃO PAULO; VERA L. S. RIGONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; MARCOS TAVARES DIAS, CPAF-AP; OMAR MERTINS, UNIVERSIDADE FEDERAL DE SÃO PAULO.MADRID, R. R. MMATHEWS, P. D.PATTA, A. C. F.GONZALES-FLORES, A. P.RAMIREZ. C. A. B.RIGONI, V. L. S.TAVARES-DIAS, M.MERTINS, O.2023-04-13T15:09:39Z2023-04-13T15:09:39Z2022-09-222021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHeliyon, v. 7, n. 1, e05820, Jan. 2021.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1146721https://doi.org/10.1016/j.heliyon.2020.e05820enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2023-04-13T15:09:39Zoai:www.alice.cnptia.embrapa.br:doc/1146721Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542023-04-13T15:09:39falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542023-04-13T15:09:39Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
title |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
spellingShingle |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. MADRID, R. R. M Peixe Corydoras Ivermectin |
title_short |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
title_full |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
title_fullStr |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
title_full_unstemmed |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
title_sort |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
author |
MADRID, R. R. M |
author_facet |
MADRID, R. R. M MATHEWS, P. D. PATTA, A. C. F. GONZALES-FLORES, A. P. RAMIREZ. C. A. B. RIGONI, V. L. S. TAVARES-DIAS, M. MERTINS, O. |
author_role |
author |
author2 |
MATHEWS, P. D. PATTA, A. C. F. GONZALES-FLORES, A. P. RAMIREZ. C. A. B. RIGONI, V. L. S. TAVARES-DIAS, M. MERTINS, O. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
RAFAEL R. M. MADRID, UNIVERSIDADE FEDERAL DE SÃO PAULO; PATRICK D. MATHEWS, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANA C. M. F. PATTA, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANAI P. GONZALES-FLORES, INSTITUTE OF RESEARCH OF THE PERUVIAN AMAZON; CARLOS A. B. RAMIREZ, UNIVERSIDADE FEDERAL DE SÃO PAULO; VERA L. S. RIGONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; MARCOS TAVARES DIAS, CPAF-AP; OMAR MERTINS, UNIVERSIDADE FEDERAL DE SÃO PAULO. |
dc.contributor.author.fl_str_mv |
MADRID, R. R. M MATHEWS, P. D. PATTA, A. C. F. GONZALES-FLORES, A. P. RAMIREZ. C. A. B. RIGONI, V. L. S. TAVARES-DIAS, M. MERTINS, O. |
dc.subject.por.fl_str_mv |
Peixe Corydoras Ivermectin |
topic |
Peixe Corydoras Ivermectin |
description |
The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2022-09-22 2023-04-13T15:09:39Z 2023-04-13T15:09:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Heliyon, v. 7, n. 1, e05820, Jan. 2021. http://www.alice.cnptia.embrapa.br/alice/handle/doc/1146721 https://doi.org/10.1016/j.heliyon.2020.e05820 |
identifier_str_mv |
Heliyon, v. 7, n. 1, e05820, Jan. 2021. |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1146721 https://doi.org/10.1016/j.heliyon.2020.e05820 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
instname_str |
Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503543803084800 |