Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.

Detalhes bibliográficos
Autor(a) principal: JESUS, D. R.
Data de Publicação: 2015
Outros Autores: BARBOSA, L. N., PRANDO, T. B. L., MARTINS, L. F., GASPAROTTO, F., GUEDES, K. M. R., DRAGUNSKI, D. C., LOURENÇO, E. L. B., DALSENTER, P. R., GASPAROTTO JUNIOR, A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1026401
Resumo: The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.
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spelling Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.Biodegradable filmsFCSADegradable productsTóxicoMandiocaManihot EsculentaBiodegradationThe large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.DOUGLAS ROSSI JESUS, UNIPAR - Universidade Paranaense; LORENA NERIS BARBOSA, UFPR; THIAGO BRUNO LIMA PRANDO, UNIPAR; LEONARDO FRANCO MARTINS, UNIPAR; FRANCIELLI GASPAROTTO, CESUMAR; KARLA MORAES ROCHA GUEDES, CPAP; DOUGLAS CARDOSO DRAGUNSKI, UNIPAR; EMERSON LUIZ BOTELHO LOURENÇO, UNIPAR; PAULO ROBERTO DALSENTER, UFPR; ARQUIMEDES GASPAROTTO JUNIOR, UFGD.JESUS, D. R.BARBOSA, L. N.PRANDO, T. B. L.MARTINS, L. F.GASPAROTTO, F.GUEDES, K. M. R.DRAGUNSKI, D. C.LOURENÇO, E. L. B.DALSENTER, P. R.GASPAROTTO JUNIOR, A.2017-04-16T11:59:40Z2017-04-16T11:59:40Z2015-10-1420152017-04-16T11:59:40Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEvidence-Based Complementary and Alternative Medicine, 2015.http://www.alice.cnptia.embrapa.br/alice/handle/doc/102640110.1155/2015/390416enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2017-08-16T04:21:56Zoai:www.alice.cnptia.embrapa.br:doc/1026401Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542017-08-16T04:21:56falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542017-08-16T04:21:56Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
title Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
spellingShingle Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
JESUS, D. R.
Biodegradable films
FCSA
Degradable products
Tóxico
Mandioca
Manihot Esculenta
Biodegradation
title_short Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
title_full Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
title_fullStr Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
title_full_unstemmed Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
title_sort Ninety-day oral toxicity assessment of an alternative biopolymer for controlled release drug delivery systems obtained from cassava starch acetate.
author JESUS, D. R.
author_facet JESUS, D. R.
BARBOSA, L. N.
PRANDO, T. B. L.
MARTINS, L. F.
GASPAROTTO, F.
GUEDES, K. M. R.
DRAGUNSKI, D. C.
LOURENÇO, E. L. B.
DALSENTER, P. R.
GASPAROTTO JUNIOR, A.
author_role author
author2 BARBOSA, L. N.
PRANDO, T. B. L.
MARTINS, L. F.
GASPAROTTO, F.
GUEDES, K. M. R.
DRAGUNSKI, D. C.
LOURENÇO, E. L. B.
DALSENTER, P. R.
GASPAROTTO JUNIOR, A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DOUGLAS ROSSI JESUS, UNIPAR - Universidade Paranaense; LORENA NERIS BARBOSA, UFPR; THIAGO BRUNO LIMA PRANDO, UNIPAR; LEONARDO FRANCO MARTINS, UNIPAR; FRANCIELLI GASPAROTTO, CESUMAR; KARLA MORAES ROCHA GUEDES, CPAP; DOUGLAS CARDOSO DRAGUNSKI, UNIPAR; EMERSON LUIZ BOTELHO LOURENÇO, UNIPAR; PAULO ROBERTO DALSENTER, UFPR; ARQUIMEDES GASPAROTTO JUNIOR, UFGD.
dc.contributor.author.fl_str_mv JESUS, D. R.
BARBOSA, L. N.
PRANDO, T. B. L.
MARTINS, L. F.
GASPAROTTO, F.
GUEDES, K. M. R.
DRAGUNSKI, D. C.
LOURENÇO, E. L. B.
DALSENTER, P. R.
GASPAROTTO JUNIOR, A.
dc.subject.por.fl_str_mv Biodegradable films
FCSA
Degradable products
Tóxico
Mandioca
Manihot Esculenta
Biodegradation
topic Biodegradable films
FCSA
Degradable products
Tóxico
Mandioca
Manihot Esculenta
Biodegradation
description The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity inWistar rats, indicating possible safety of this biofilm.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-14
2015
2017-04-16T11:59:40Z
2017-04-16T11:59:40Z
2017-04-16T11:59:40Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Evidence-Based Complementary and Alternative Medicine, 2015.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1026401
10.1155/2015/390416
identifier_str_mv Evidence-Based Complementary and Alternative Medicine, 2015.
10.1155/2015/390416
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1026401
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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