Benefits and harmfulness of the use of bisphosphonate in the osseointegration process for dental implants in patients with osteoporosis: a concise systematic review

• Autor(a) principal: Ortega, Liliane Fernanda Luz
• Data de Publicação: 2022
• Outros Autores: Cicareli, Alvaro José, Kassis, Elias Naim
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: MedNEXT Journal of Medical and Health Sciences
• Texto Completo: https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/194
• topic: Dental implants; Osteoporosis; Bisphosphonate; Osseointegration; Osteonecrosis

Introduction: In the scenario of implantology and osteoporosis, it is highlighted that the high need and use of treatments related to dental implants result from the combined effect of several factors, highlighting aging and bone fragility. In this context, osteoporosis is a global bone disease prevalent in human aging. Bisphosphonates (BPs) are commonly used as therapy because they influence hard and soft tissue calcium metabolism. Objective: It was to present the main considerations and scientific evidence of the use of bisphosphonate in the osseointegration process for dental implants in patients with osteoporosis, as well as to emphasize the harm caused by the occurrence of osteonecrosis. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from February 2022 to May 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 110 articles were found. In total, 58 articles were fully evaluated and 28 were included and evaluated in this study. Of the initial total of articles, 26 articles were excluded because they did not meet the GRADE classification, and 4 were excluded because they presented a risk of bias. It was concluded that osteoporosis is a metabolic condition that affects alveolar bone density, which may compromise the dental implant process. Therefore, the careful use of bisphosphonates is necessary for the osseointegration process, however, dental surgeons are encouraged to know the diagnosis so that they can make a careful assessment, observing the quality of the bone through routine imaging exams, to prevent osteonecrosis. In addition, alendronate sodium is used to decrease bone resorption, being an adjuvant therapeutic agent for the treatment of osteoporosis.