Influence of IL6 gene genetic variants on major depressive disorder: a review

• Autor(a) principal: Soares, Antônio Avelino Ferreira
• Data de Publicação: 2023
• Outros Autores: Bonasser, Larissa Sousa Silva, Silva, Calliandra Maria de Souza, Fratelli, Caroline Ferreira, Rodrigues, Izabel Cristina
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: REVISA : Revista de Divulgação Científica Sena Aires (Online)
• Texto Completo: https://rdcsa.emnuvens.com.br/revista/article/view/118
• topic: IL-6; Polimorfismo; Transtorno Depressivo Maior; IL-6; Polymorphism; Major Depressive Disorder

Objective: To elucidate the clinical picture of major depressive disorder (MDD) and to verify the association of this condition with polymorphisms of the IL6 gene. Method: This was a systematic review with the search of original articles in the databases Scopus, Web of Science, PubMed and VHL, which brought information about genetic variants that were related to polymorphisms of the IL6 gene. Studies that did not present complete data, including statistical data, reviews, meta-analyses and abstracts, were excluded. Results: A total of 54 articles were found in the databases. The Rayyan platform was used to remove the duplicates and read the abstracts for initial selection. There were 12 articles, where those that were freely accessible were sent for full reading, totaling 5 articles for this review. Conclusion: Evidence suggests a systemic condition in MDD and data demonstrate inflammatory changes. Given that in most studies patients with MDD had higher inflammatory states, there seems to be a relationship between IL-6 and the disorder. IL-6 induces changes in the brain, activation of microglia and controls the health of neurons, and may make tangible a relationship between polymorphisms and the disease, but there are not many studies in the area.