Uncária Tomentosa (Wild.) D.C. in inflammatory processes in Alzheimer's disease

• Autor(a) principal: Barbosa, Fernando Campos
• Data de Publicação: 2023
• Outros Autores: Rezende, Janaina Drawanz Pereira, Silva, Emiliana Junqueira da
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: REVISA : Revista de Divulgação Científica Sena Aires (Online)
• Texto Completo: https://rdcsa.emnuvens.com.br/revista/article/view/207
• topic: Uncaria Tomentosa; Unha-de-gato; Doença de Alzheimer; Uncaria Tomentosa; Cat´s claw; Alzheimer’ Disease

Objective: to explore the mechanisms involved in the triggering and progression of Alzheimer's disease (AD) in order to support the suggestion of the Uncaria Tomentosa (Wild.) plant as another adjuvant therapeutic possibility for the prevention and treatment of AD. Method: This is a narrative review of the literature conducted with a search for articles published on indexed bases and directly in the journals of interest, using as descriptors "Uncária Tomentosa", "Alzheimer's disease", and the respective terms in English. Results: with advances to understand the molecular mechanisms that trigger the effects presented in the development of AD, the various mechanisms of phytocompounds present in the plant suggest its use as neuroprotector, by anti-inflammatory, immunomodulatory and antioxidant mechanisms, whose evidence in the literature is presented to defend its use in this pathology. Conclusion: evidence was found to suggest the inclusion of Uncaria tomentosa (Wild.) as a possible complementary therapy in the treatment of AD. Its use should be better explored for application as a complementary treatment to conventional therapies for AD..