Transcriptome Analysis of Chicken Embryo Fibroblast Cell Infected with Marek’s Disease Virus of GX0101 ∆ LTR

• Autor(a) principal: Li,X
• Data de Publicação: 2017
• Outros Autores: Su,S, Cui,N, Zhou,H, Liu,X, Cui,Z
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Poultry Science (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000200179
• topic: Gene profiling; chicken; CEF cell; GX0101ΔLTR MDV.

ABSTRACT Marek’s disease (MD), a lymphoproliferative disorder of chickens caused by the MD virus (MDV), is economically significant. The resistance/susceptibility to MD is controlled by host genetics. The host response to different virus strains varies. The pathogenicity of REV-LTR deleted GX0101∆LTR MDV has been previously reported. However, the precise molecular mechanism of the response of chickens to GX0101ΔLTR remains unclear. The current study aimed at identifying the genes and pathways involved in the response to GX0101ΔLTR virus infection in specific pathogen-free chicken embryo fibroblast cells using global transcriptome analysis. A total of 1,633 genes associated with GX0101ΔLTR infection were identified. Functional analysis showed that the cytokine-cytokine receptor interaction plays an important role in the response to GX0101ΔLTR infection.