REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS

Detalhes bibliográficos
Autor(a) principal: Bezerra, Raquel Pedrosa
Data de Publicação: 2021
Outros Autores: de Arruda, Maria Carla Santana, Calaça, Priscilla Régia de Andrade, Cavalcanti, Vivianne Lays Ribeiro, Brandão, Romero Marcos Pedrosa Costa, Porto, Ana Lúcia Figueiredo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Valore (Online)
Texto Completo: https://revistavalore.emnuvens.com.br/valore/article/view/554
Resumo: Resumo O câncer é considerado um problema de saúde pública e atualmente sua incidência tem aumentado em todo o mundo. Infelizmente, os métodos convencionais empregados no tratamento são causadores de efeitos colaterais incômodos, impulsionando a busca por novas terapias, principalmente de fontes naturais. As microalgas e cianobactérias tem demonstrado potencial no tratamento antitumoral, despertando interesse em pesquisas científicas. Esta revisão integrativa, utilizou artigos originais que analisaram a atividade antitumoral de bioativos extraídos de microalgas ou cianobactérias em modelos experimentais in vitro e/ou in vivo publicados em língua inglesa nas bases de dados PubMed (NCBI), Google scholar e os periódicos da CAPES entre 2009 e 2019. 107 artigos atenderam aos critérios de elegibilidade. Estes apresentaram 58 diferentes gêneros de microalgas e cianobactérias, sendo os gêneros Spirulina sp. e Chlorella sp. os mais relatados. O extrato aquoso e os compostos purificados ficocianina e β-caroteno são os mais promissores em diferentes linhagens, principalmente MCF-7 de tumor mamário. O principal mecanismo de ação destes compostos foi a inibição da proliferação de células tumorais. O número de artigos publicados sobre atividade antitumoral de bioativos obtidos destes microrganismos é crescente, no entanto a identificação dos compostos e o conhecimento sobre seus mecanismos de ação ainda são limitados.
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spelling REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIASResumo O câncer é considerado um problema de saúde pública e atualmente sua incidência tem aumentado em todo o mundo. Infelizmente, os métodos convencionais empregados no tratamento são causadores de efeitos colaterais incômodos, impulsionando a busca por novas terapias, principalmente de fontes naturais. As microalgas e cianobactérias tem demonstrado potencial no tratamento antitumoral, despertando interesse em pesquisas científicas. Esta revisão integrativa, utilizou artigos originais que analisaram a atividade antitumoral de bioativos extraídos de microalgas ou cianobactérias em modelos experimentais in vitro e/ou in vivo publicados em língua inglesa nas bases de dados PubMed (NCBI), Google scholar e os periódicos da CAPES entre 2009 e 2019. 107 artigos atenderam aos critérios de elegibilidade. Estes apresentaram 58 diferentes gêneros de microalgas e cianobactérias, sendo os gêneros Spirulina sp. e Chlorella sp. os mais relatados. O extrato aquoso e os compostos purificados ficocianina e β-caroteno são os mais promissores em diferentes linhagens, principalmente MCF-7 de tumor mamário. O principal mecanismo de ação destes compostos foi a inibição da proliferação de células tumorais. O número de artigos publicados sobre atividade antitumoral de bioativos obtidos destes microrganismos é crescente, no entanto a identificação dos compostos e o conhecimento sobre seus mecanismos de ação ainda são limitados.FaSFFundação de amparo à ciencia e tecnologia do estado de Pernambuco- FACEPEBezerra, Raquel Pedrosade Arruda, Maria Carla SantanaCalaça, Priscilla Régia de AndradeCavalcanti, Vivianne Lays RibeiroBrandão, Romero Marcos Pedrosa CostaPorto, Ana Lúcia Figueiredo2021-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistavalore.emnuvens.com.br/valore/article/view/55410.22408/reva602021554e-6001Revista Valore; v. 6 (2021): Revista Valore; e-60012526-043X2525-900810.22408/reva602021reponame:Revista Valore (Online)instname:Faculdade Sul Fluminense (FASF)instacron:FASFporhttps://revistavalore.emnuvens.com.br/valore/article/view/554/753https://revistavalore.emnuvens.com.br/valore/article/downloadSuppFile/554/73/*ref*/AL‐AWADHI, F. 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Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity. International journal of biological macromolecules, v. 134, p. 976-983. 2019.Direitos autorais 2021 Revista Valoreinfo:eu-repo/semantics/openAccess2021-08-02T03:00:04Zoai:valore.emnuvens.com.br:article/554Revistahttps://revistavalore.emnuvens.com.br/valore/indexPUBhttps://revistavalore.emnuvens.com.br/valore/oai||revistavalore@gmail.com|| marcus.barbosa1979@gmail.com|| felipetriani@gmail.com2526-043X2525-9008opendoar:2021-08-02T03:00:04Revista Valore (Online) - Faculdade Sul Fluminense (FASF)false
dc.title.none.fl_str_mv REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
title REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
spellingShingle REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
Bezerra, Raquel Pedrosa
title_short REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
title_full REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
title_fullStr REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
title_full_unstemmed REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
title_sort REVISÃO INTEGRATIVA SOBRE ATIVIDADE ANTITUMORAL DE MICROALGAS E CIANOBACTÉRIAS
author Bezerra, Raquel Pedrosa
author_facet Bezerra, Raquel Pedrosa
de Arruda, Maria Carla Santana
Calaça, Priscilla Régia de Andrade
Cavalcanti, Vivianne Lays Ribeiro
Brandão, Romero Marcos Pedrosa Costa
Porto, Ana Lúcia Figueiredo
author_role author
author2 de Arruda, Maria Carla Santana
Calaça, Priscilla Régia de Andrade
Cavalcanti, Vivianne Lays Ribeiro
Brandão, Romero Marcos Pedrosa Costa
Porto, Ana Lúcia Figueiredo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fundação de amparo à ciencia e tecnologia do estado de Pernambuco- FACEPE
dc.contributor.author.fl_str_mv Bezerra, Raquel Pedrosa
de Arruda, Maria Carla Santana
Calaça, Priscilla Régia de Andrade
Cavalcanti, Vivianne Lays Ribeiro
Brandão, Romero Marcos Pedrosa Costa
Porto, Ana Lúcia Figueiredo
description Resumo O câncer é considerado um problema de saúde pública e atualmente sua incidência tem aumentado em todo o mundo. Infelizmente, os métodos convencionais empregados no tratamento são causadores de efeitos colaterais incômodos, impulsionando a busca por novas terapias, principalmente de fontes naturais. As microalgas e cianobactérias tem demonstrado potencial no tratamento antitumoral, despertando interesse em pesquisas científicas. Esta revisão integrativa, utilizou artigos originais que analisaram a atividade antitumoral de bioativos extraídos de microalgas ou cianobactérias em modelos experimentais in vitro e/ou in vivo publicados em língua inglesa nas bases de dados PubMed (NCBI), Google scholar e os periódicos da CAPES entre 2009 e 2019. 107 artigos atenderam aos critérios de elegibilidade. Estes apresentaram 58 diferentes gêneros de microalgas e cianobactérias, sendo os gêneros Spirulina sp. e Chlorella sp. os mais relatados. O extrato aquoso e os compostos purificados ficocianina e β-caroteno são os mais promissores em diferentes linhagens, principalmente MCF-7 de tumor mamário. O principal mecanismo de ação destes compostos foi a inibição da proliferação de células tumorais. O número de artigos publicados sobre atividade antitumoral de bioativos obtidos destes microrganismos é crescente, no entanto a identificação dos compostos e o conhecimento sobre seus mecanismos de ação ainda são limitados.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-14
dc.type.none.fl_str_mv
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistavalore.emnuvens.com.br/valore/article/view/554
10.22408/reva602021554e-6001
url https://revistavalore.emnuvens.com.br/valore/article/view/554
identifier_str_mv 10.22408/reva602021554e-6001
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistavalore.emnuvens.com.br/valore/article/view/554/753
https://revistavalore.emnuvens.com.br/valore/article/downloadSuppFile/554/73
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dc.rights.driver.fl_str_mv Direitos autorais 2021 Revista Valore
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos autorais 2021 Revista Valore
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv FaSF
publisher.none.fl_str_mv FaSF
dc.source.none.fl_str_mv Revista Valore; v. 6 (2021): Revista Valore; e-6001
2526-043X
2525-9008
10.22408/reva602021
reponame:Revista Valore (Online)
instname:Faculdade Sul Fluminense (FASF)
instacron:FASF
instname_str Faculdade Sul Fluminense (FASF)
instacron_str FASF
institution FASF
reponame_str Revista Valore (Online)
collection Revista Valore (Online)
repository.name.fl_str_mv Revista Valore (Online) - Faculdade Sul Fluminense (FASF)
repository.mail.fl_str_mv ||revistavalore@gmail.com|| marcus.barbosa1979@gmail.com|| felipetriani@gmail.com
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