Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) |
Texto Completo: | http://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139 |
Resumo: | Objetive: this study intends to verify the correlation of mammographic breast density and expression level of enzymes aromatase and 17Î’HSD1 in infiltrating ductal carcinoma. Methods: Forty-eight cases were evaluated by mammographic image grading density by ACR BI-RADS® and by tissue micro array (TMA) to expression immunohistochemically screened with anti-aromatase polyclonal antibodies and anti-17βhsd1 monoclonal antibodies. Results: In relation to breast density, in absolute numbers and percentages, we found the following results: in category 1, 17 patients (35.42%), category 2, 17 patients (35.42%), category 3, 6 patients (12 50%) and category 4, 8 patients (16.67%). The aromatase expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of aromatase with breast density (p = 0.917). The 17βHSD1 expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of 17βHSD1 with breast density (p= 0.666). The no significant correlation between the expression of 17βHSD1 with breast density was found to be unchanged even when the analysis of the proposed subgroups (BMI greater than or less than 25, aged greater or less than 50 years and high or low mammographic density). Statistical analysis showed a significant correlation between the expression of aromatase and 17βHSD1 (p= 0.00048). Conclusion: After analysis of our results we can conclude that there was no positive association between mammographic breast density and expression of enzymes aromatase and 17βHSD1.Keywords: Aromatase, Breast neoplasms, Mammography, Hydroxysteroid dehydrogenases |
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Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mamaObjetive: this study intends to verify the correlation of mammographic breast density and expression level of enzymes aromatase and 17Î’HSD1 in infiltrating ductal carcinoma. Methods: Forty-eight cases were evaluated by mammographic image grading density by ACR BI-RADS® and by tissue micro array (TMA) to expression immunohistochemically screened with anti-aromatase polyclonal antibodies and anti-17βhsd1 monoclonal antibodies. Results: In relation to breast density, in absolute numbers and percentages, we found the following results: in category 1, 17 patients (35.42%), category 2, 17 patients (35.42%), category 3, 6 patients (12 50%) and category 4, 8 patients (16.67%). The aromatase expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of aromatase with breast density (p = 0.917). The 17βHSD1 expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of 17βHSD1 with breast density (p= 0.666). The no significant correlation between the expression of 17βHSD1 with breast density was found to be unchanged even when the analysis of the proposed subgroups (BMI greater than or less than 25, aged greater or less than 50 years and high or low mammographic density). Statistical analysis showed a significant correlation between the expression of aromatase and 17βHSD1 (p= 0.00048). Conclusion: After analysis of our results we can conclude that there was no positive association between mammographic breast density and expression of enzymes aromatase and 17βHSD1.Keywords: Aromatase, Breast neoplasms, Mammography, Hydroxysteroid dehydrogenasesFaculdade de Ciências Médicas da Santa Casa de São Paulo2018-07-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo; v. 60 n. 3 (2015): Set/Dez; 111-1161809-30190101-6067reponame:Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online)instname:Faculdade de Ciências Médicas da Santa Casa de São Pauloinstacron:FCMSCSPporhttp://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139/145Copyright (c) 2018 Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Pauloinfo:eu-repo/semantics/openAccessIwamoto, Valdemar MitsunoriOliveira, Vilmar Marques deBagnoli, FábioRinaldi, Jose FranciscoRoveda Junior, DecioSilva, Maria Antonieta Longo Galvão daAldrighi, José Mendes2021-09-29T05:01:48Zoai:ojs2.arquivosmedicos.fcmsantacasasp.edu.br:article/139Revistahttp://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSPONGhttp://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/oaiarquivosmedicos@fcmsantacasasp.edu.br||1809-30190101-6067opendoar:2021-09-29T05:01:48Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) - Faculdade de Ciências Médicas da Santa Casa de São Paulofalse |
dc.title.none.fl_str_mv |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
title |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
spellingShingle |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama Iwamoto, Valdemar Mitsunori |
title_short |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
title_full |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
title_fullStr |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
title_full_unstemmed |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
title_sort |
Correlation between mammographic breast density and expression of aromatase and 17 β hydroxysteroid dehydrogenase Type I (17βHSD1) enzymes in breast cancer / Correlação entre a densidade mamográfica e expressão da aromatase e 17 β hydroxysteroid desidrogenase tipo I (17βHSD1) no câncer de mama |
author |
Iwamoto, Valdemar Mitsunori |
author_facet |
Iwamoto, Valdemar Mitsunori Oliveira, Vilmar Marques de Bagnoli, Fábio Rinaldi, Jose Francisco Roveda Junior, Decio Silva, Maria Antonieta Longo Galvão da Aldrighi, José Mendes |
author_role |
author |
author2 |
Oliveira, Vilmar Marques de Bagnoli, Fábio Rinaldi, Jose Francisco Roveda Junior, Decio Silva, Maria Antonieta Longo Galvão da Aldrighi, José Mendes |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Iwamoto, Valdemar Mitsunori Oliveira, Vilmar Marques de Bagnoli, Fábio Rinaldi, Jose Francisco Roveda Junior, Decio Silva, Maria Antonieta Longo Galvão da Aldrighi, José Mendes |
description |
Objetive: this study intends to verify the correlation of mammographic breast density and expression level of enzymes aromatase and 17Î’HSD1 in infiltrating ductal carcinoma. Methods: Forty-eight cases were evaluated by mammographic image grading density by ACR BI-RADS® and by tissue micro array (TMA) to expression immunohistochemically screened with anti-aromatase polyclonal antibodies and anti-17βhsd1 monoclonal antibodies. Results: In relation to breast density, in absolute numbers and percentages, we found the following results: in category 1, 17 patients (35.42%), category 2, 17 patients (35.42%), category 3, 6 patients (12 50%) and category 4, 8 patients (16.67%). The aromatase expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of aromatase with breast density (p = 0.917). The 17βHSD1 expression was positive in 18 (37.5%). Statistical analysis showed no significant correlation between the expression of 17βHSD1 with breast density (p= 0.666). The no significant correlation between the expression of 17βHSD1 with breast density was found to be unchanged even when the analysis of the proposed subgroups (BMI greater than or less than 25, aged greater or less than 50 years and high or low mammographic density). Statistical analysis showed a significant correlation between the expression of aromatase and 17βHSD1 (p= 0.00048). Conclusion: After analysis of our results we can conclude that there was no positive association between mammographic breast density and expression of enzymes aromatase and 17βHSD1.Keywords: Aromatase, Breast neoplasms, Mammography, Hydroxysteroid dehydrogenases |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139 |
url |
http://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://arquivosmedicos.fcmsantacasasp.edu.br/index.php/AMSCSP/article/view/139/145 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade de Ciências Médicas da Santa Casa de São Paulo |
publisher.none.fl_str_mv |
Faculdade de Ciências Médicas da Santa Casa de São Paulo |
dc.source.none.fl_str_mv |
Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo; v. 60 n. 3 (2015): Set/Dez; 111-116 1809-3019 0101-6067 reponame:Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) instname:Faculdade de Ciências Médicas da Santa Casa de São Paulo instacron:FCMSCSP |
instname_str |
Faculdade de Ciências Médicas da Santa Casa de São Paulo |
instacron_str |
FCMSCSP |
institution |
FCMSCSP |
reponame_str |
Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) |
collection |
Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) |
repository.name.fl_str_mv |
Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo (Online) - Faculdade de Ciências Médicas da Santa Casa de São Paulo |
repository.mail.fl_str_mv |
arquivosmedicos@fcmsantacasasp.edu.br|| |
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