Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de ginecologia e obstetrícia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000400157 |
Resumo: | PURPOSE: It was to assess the risk of cardiovascular disease (CVD) in breast cancer survivors (BCS).METHODS: This cross-sectional study analyzed 67 BCS, aged 45 -65 years, who underwent complete oncological treatment, but had not received hormone therapy, tamoxifen or aromatase inhibitors during the previous 6 months. Lipid profile and CVD risk were evaluated, the latter using the Framingham and Systematic COronary Risk Evaluation (SCORE) models. The agreement between cardiovascular risk models was analyzed by calculating a kappa coefficient and its 95% confidence interval (CI).RESULTS: Mean subject age was 53.2±6.0 years, with rates of obesity, hypertension, and dyslipidemia of 25, 34 and 90%, respectively. The most frequent lipid abnormalities were high total cholesterol (70%), high LDL-C (51%) and high non-HDL-C (48%) concentrations. Based on the Framingham score, 22% of the participants had a high risk for coronary artery disease. According to the SCORE model, 100 and 93% of the participants were at low risk for fatal CVD in populations at low and high risk, respectively, for CVD. The agreement between the Framingham and SCORE risk models was poor (kappa: 0.1; 95%CI 0.01 -0.2) for populations at high risk for CVD.CONCLUSIONS: These findings indicate the need to include lipid profile and CVD risk assessment in the follow-up of BCS, focusing on adequate control of serum lipid concentrations. |
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Revista brasileira de ginecologia e obstetrícia (Online) |
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Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk modelsBreast neoplasmsCardiovascular diseasesCoronary artery diseaseDyslipidemiasHypertensionRadiotherapyModels, cardiovascularPURPOSE: It was to assess the risk of cardiovascular disease (CVD) in breast cancer survivors (BCS).METHODS: This cross-sectional study analyzed 67 BCS, aged 45 -65 years, who underwent complete oncological treatment, but had not received hormone therapy, tamoxifen or aromatase inhibitors during the previous 6 months. Lipid profile and CVD risk were evaluated, the latter using the Framingham and Systematic COronary Risk Evaluation (SCORE) models. The agreement between cardiovascular risk models was analyzed by calculating a kappa coefficient and its 95% confidence interval (CI).RESULTS: Mean subject age was 53.2±6.0 years, with rates of obesity, hypertension, and dyslipidemia of 25, 34 and 90%, respectively. The most frequent lipid abnormalities were high total cholesterol (70%), high LDL-C (51%) and high non-HDL-C (48%) concentrations. Based on the Framingham score, 22% of the participants had a high risk for coronary artery disease. According to the SCORE model, 100 and 93% of the participants were at low risk for fatal CVD in populations at low and high risk, respectively, for CVD. The agreement between the Framingham and SCORE risk models was poor (kappa: 0.1; 95%CI 0.01 -0.2) for populations at high risk for CVD.CONCLUSIONS: These findings indicate the need to include lipid profile and CVD risk assessment in the follow-up of BCS, focusing on adequate control of serum lipid concentrations.Federação Brasileira das Sociedades de Ginecologia e Obstetrícia2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000400157Revista Brasileira de Ginecologia e Obstetrícia v.36 n.4 2014reponame:Revista brasileira de ginecologia e obstetrícia (Online)instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)instacron:FEBRASGO10.1590/S0100-720320140050.0002info:eu-repo/semantics/openAccessSousa-e-Silva,Érika Pereira deConde,Délio MarquesCosta-Paiva,LúciaMartinez,Edson ZangiacomiPinto-Neto,Aarão Mendeseng2015-09-21T00:00:00Zoai:scielo:S0100-72032014000400157Revistahttp://www.scielo.br/rbgohttps://old.scielo.br/oai/scielo-oai.phppublicações@febrasgo.org.br||rbgo@fmrp.usp.br1806-93390100-7203opendoar:2015-09-21T00:00Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)false |
dc.title.none.fl_str_mv |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
title |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
spellingShingle |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models Sousa-e-Silva,Érika Pereira de Breast neoplasms Cardiovascular diseases Coronary artery disease Dyslipidemias Hypertension Radiotherapy Models, cardiovascular |
title_short |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
title_full |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
title_fullStr |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
title_full_unstemmed |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
title_sort |
Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models |
author |
Sousa-e-Silva,Érika Pereira de |
author_facet |
Sousa-e-Silva,Érika Pereira de Conde,Délio Marques Costa-Paiva,Lúcia Martinez,Edson Zangiacomi Pinto-Neto,Aarão Mendes |
author_role |
author |
author2 |
Conde,Délio Marques Costa-Paiva,Lúcia Martinez,Edson Zangiacomi Pinto-Neto,Aarão Mendes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sousa-e-Silva,Érika Pereira de Conde,Délio Marques Costa-Paiva,Lúcia Martinez,Edson Zangiacomi Pinto-Neto,Aarão Mendes |
dc.subject.por.fl_str_mv |
Breast neoplasms Cardiovascular diseases Coronary artery disease Dyslipidemias Hypertension Radiotherapy Models, cardiovascular |
topic |
Breast neoplasms Cardiovascular diseases Coronary artery disease Dyslipidemias Hypertension Radiotherapy Models, cardiovascular |
description |
PURPOSE: It was to assess the risk of cardiovascular disease (CVD) in breast cancer survivors (BCS).METHODS: This cross-sectional study analyzed 67 BCS, aged 45 -65 years, who underwent complete oncological treatment, but had not received hormone therapy, tamoxifen or aromatase inhibitors during the previous 6 months. Lipid profile and CVD risk were evaluated, the latter using the Framingham and Systematic COronary Risk Evaluation (SCORE) models. The agreement between cardiovascular risk models was analyzed by calculating a kappa coefficient and its 95% confidence interval (CI).RESULTS: Mean subject age was 53.2±6.0 years, with rates of obesity, hypertension, and dyslipidemia of 25, 34 and 90%, respectively. The most frequent lipid abnormalities were high total cholesterol (70%), high LDL-C (51%) and high non-HDL-C (48%) concentrations. Based on the Framingham score, 22% of the participants had a high risk for coronary artery disease. According to the SCORE model, 100 and 93% of the participants were at low risk for fatal CVD in populations at low and high risk, respectively, for CVD. The agreement between the Framingham and SCORE risk models was poor (kappa: 0.1; 95%CI 0.01 -0.2) for populations at high risk for CVD.CONCLUSIONS: These findings indicate the need to include lipid profile and CVD risk assessment in the follow-up of BCS, focusing on adequate control of serum lipid concentrations. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000400157 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000400157 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-720320140050.0002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ginecologia e Obstetrícia v.36 n.4 2014 reponame:Revista brasileira de ginecologia e obstetrícia (Online) instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO |
instname_str |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
instacron_str |
FEBRASGO |
institution |
FEBRASGO |
reponame_str |
Revista brasileira de ginecologia e obstetrícia (Online) |
collection |
Revista brasileira de ginecologia e obstetrícia (Online) |
repository.name.fl_str_mv |
Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
repository.mail.fl_str_mv |
publicações@febrasgo.org.br||rbgo@fmrp.usp.br |
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1754115942726500352 |