Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Polímeros (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000200411 |
Resumo: | Abstract Poly(ε-caprolactone)-block-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, triblock) and Poly(ε-caprolactone)-block-(poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)-poly (ε-caprolactone) (PCL-PEO-PPO-PEO-PCL, pentablock) copolymers were synthesized by transesterification with reduction of PCL molecular mass, enabling fewer reactions, lower temperatures, and eliminating extensive purification steps. Free hydrophilic groups were removed from the samples by selective precipitation, and 1H-NMR, FTIR, GPC and DSC analyses characterized the structure and properties of the resulting copolymers. The detection of remaining hydrophilic groups indicates the formation of the amphiphilic block copolymers (BCPs). Further, we obtained polymeric nanoparticles with monodisperse size distribution profiles by nano-precipitation from both the triblock and the pentablock copolymers using a microfluidic device, resulting 144.6 and 188.9 nm size and 0.093 and 0.102 nm polydispersity index, respectively. The nanoparticle assembly depends on the copolymer composition, and the possibility of nanoparticle assembly corroborates to the block structure of the copolymers, and the success of this synthesis route to obtain BCPs. |
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Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle productioncopolymersPluronic F127®Poly(ε-caprolactone)Poly(ethylene glycol)transesterificationAbstract Poly(ε-caprolactone)-block-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, triblock) and Poly(ε-caprolactone)-block-(poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)-poly (ε-caprolactone) (PCL-PEO-PPO-PEO-PCL, pentablock) copolymers were synthesized by transesterification with reduction of PCL molecular mass, enabling fewer reactions, lower temperatures, and eliminating extensive purification steps. Free hydrophilic groups were removed from the samples by selective precipitation, and 1H-NMR, FTIR, GPC and DSC analyses characterized the structure and properties of the resulting copolymers. The detection of remaining hydrophilic groups indicates the formation of the amphiphilic block copolymers (BCPs). Further, we obtained polymeric nanoparticles with monodisperse size distribution profiles by nano-precipitation from both the triblock and the pentablock copolymers using a microfluidic device, resulting 144.6 and 188.9 nm size and 0.093 and 0.102 nm polydispersity index, respectively. The nanoparticle assembly depends on the copolymer composition, and the possibility of nanoparticle assembly corroborates to the block structure of the copolymers, and the success of this synthesis route to obtain BCPs.Associação Brasileira de Polímeros2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000200411Polímeros v.29 n.2 2019reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.02918info:eu-repo/semantics/openAccessDias,André Rocha MonteiroMiranda,Beatriz Nogueira Messias deCobas-Gomez,HouariPoço,João Guilherme RochaRubio,Mario Ricardo GongoraOliveira,Adriano Marim deeng2019-07-02T00:00:00Zoai:scielo:S0104-14282019000200411Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2019-07-02T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false |
dc.title.none.fl_str_mv |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
title |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
spellingShingle |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production Dias,André Rocha Monteiro copolymers Pluronic F127® Poly(ε-caprolactone) Poly(ethylene glycol) transesterification |
title_short |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
title_full |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
title_fullStr |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
title_full_unstemmed |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
title_sort |
Synthesis and characterization of amphiphilic block copolymers by transesterification for nanoparticle production |
author |
Dias,André Rocha Monteiro |
author_facet |
Dias,André Rocha Monteiro Miranda,Beatriz Nogueira Messias de Cobas-Gomez,Houari Poço,João Guilherme Rocha Rubio,Mario Ricardo Gongora Oliveira,Adriano Marim de |
author_role |
author |
author2 |
Miranda,Beatriz Nogueira Messias de Cobas-Gomez,Houari Poço,João Guilherme Rocha Rubio,Mario Ricardo Gongora Oliveira,Adriano Marim de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Dias,André Rocha Monteiro Miranda,Beatriz Nogueira Messias de Cobas-Gomez,Houari Poço,João Guilherme Rocha Rubio,Mario Ricardo Gongora Oliveira,Adriano Marim de |
dc.subject.por.fl_str_mv |
copolymers Pluronic F127® Poly(ε-caprolactone) Poly(ethylene glycol) transesterification |
topic |
copolymers Pluronic F127® Poly(ε-caprolactone) Poly(ethylene glycol) transesterification |
description |
Abstract Poly(ε-caprolactone)-block-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, triblock) and Poly(ε-caprolactone)-block-(poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide)-poly (ε-caprolactone) (PCL-PEO-PPO-PEO-PCL, pentablock) copolymers were synthesized by transesterification with reduction of PCL molecular mass, enabling fewer reactions, lower temperatures, and eliminating extensive purification steps. Free hydrophilic groups were removed from the samples by selective precipitation, and 1H-NMR, FTIR, GPC and DSC analyses characterized the structure and properties of the resulting copolymers. The detection of remaining hydrophilic groups indicates the formation of the amphiphilic block copolymers (BCPs). Further, we obtained polymeric nanoparticles with monodisperse size distribution profiles by nano-precipitation from both the triblock and the pentablock copolymers using a microfluidic device, resulting 144.6 and 188.9 nm size and 0.093 and 0.102 nm polydispersity index, respectively. The nanoparticle assembly depends on the copolymer composition, and the possibility of nanoparticle assembly corroborates to the block structure of the copolymers, and the success of this synthesis route to obtain BCPs. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000200411 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000200411 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0104-1428.02918 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
dc.source.none.fl_str_mv |
Polímeros v.29 n.2 2019 reponame:Polímeros (São Carlos. Online) instname:Associação Brasileira de Polímeros (ABPol) instacron:ABPO |
instname_str |
Associação Brasileira de Polímeros (ABPol) |
instacron_str |
ABPO |
institution |
ABPO |
reponame_str |
Polímeros (São Carlos. Online) |
collection |
Polímeros (São Carlos. Online) |
repository.name.fl_str_mv |
Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol) |
repository.mail.fl_str_mv |
||revista@abpol.org.br |
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1754212590886584320 |