Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production

Detalhes bibliográficos
Autor(a) principal: Moura, Carla
Data de Publicação: 2020
Outros Autores: Trindade, Daniela, Vieira, Milena, Francisco, Luís, Ângelo, David Faustino, Alves, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8395
Resumo: This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158),MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).
id RCAP_0aacc6421008f470fe1c5f8c72b014c7
oai_identifier_str oai:iconline.ipleiria.pt:10400.8/8395
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing productionTemporomandibular joint disc,Processing conditionsPoly(+-caprolactone)Poly(ethylene glycol) diacrylateMulti-material structuresThis work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158),MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).Temporomandibular disorders (TMD) affect a substantial percentage of the population, and the resources spent on their treatment are considerable. Despite the worldwide efforts around Tissue Engineering of the temporomandibular joint (TMJ) disc, a proper implant offering a long-term solution for TMD was not yet developed. To contribute to these efforts, this work is focused on the research and development of implants for TMJ disc regeneration. Scaffolds and hydrogels mimicking the TMJ disc of black Merino sheep were produced using different materials, poly(+-caprolactone) (PCL) and poly(ethylene glycol) diacrylate (PEGDA), and as a multi-material structure. Different parameters of the scaffold manufacturing were assessed: the influence of processing temperatures, filament diameter, and biological environment. Moreover, two multimaterial approaches were also assessed, scaffold with a hydrogel shell and scaffold with a hydrogel core. It was found that increasing temperature, the scaffolds’ porosity decreases, increasing their compressive modulus. Decreasing the filament size (300 to 200 mm) decreases the compressive modulus to almost half of the initial value. Scaffolds with 200 mm filaments are the ones with a closer modulus to the native disc and their properties are maintained under hydrated conditions. The introduction of a hydrogel core in these scaffolds presented better mechanical properties to TMJ disc substitution.FrontiersIC-OnlineMoura, CarlaTrindade, DanielaVieira, MilenaFrancisco, LuísÂngelo, David FaustinoAlves, Nuno2023-04-17T14:08:14Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8395engMoura C, Trindade D, Vieira M, Francisco L, Ângelo DF and Alves N (2020) Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production. Front. Bioeng. Biotechnol. 8:342. doi: 10.3389/fbioe.2020.003422296-418510.3389/fbioe.2020.00342info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:13Zoai:iconline.ipleiria.pt:10400.8/8395Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:07.432840Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
title Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
spellingShingle Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
Moura, Carla
Temporomandibular joint disc,
Processing conditions
Poly(+-caprolactone)
Poly(ethylene glycol) diacrylate
Multi-material structures
title_short Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
title_full Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
title_fullStr Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
title_full_unstemmed Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
title_sort Multi-material implants for temporomandibular joint disc repair: Tailored additive manufacturing production
author Moura, Carla
author_facet Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
author_role author
author2 Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Moura, Carla
Trindade, Daniela
Vieira, Milena
Francisco, Luís
Ângelo, David Faustino
Alves, Nuno
dc.subject.por.fl_str_mv Temporomandibular joint disc,
Processing conditions
Poly(+-caprolactone)
Poly(ethylene glycol) diacrylate
Multi-material structures
topic Temporomandibular joint disc,
Processing conditions
Poly(+-caprolactone)
Poly(ethylene glycol) diacrylate
Multi-material structures
description This work was supported by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the Project references: UID/Multi/04044/2019; PAMI – ROTEIRO/0328/2013 (No. 022158),MATIS (CENTRO-01-0145-FEDER-000014 – 3362), and BIODISCUS (CENTRO-01-0247-FEDER-039969).
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2023-04-17T14:08:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8395
url http://hdl.handle.net/10400.8/8395
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moura C, Trindade D, Vieira M, Francisco L, Ângelo DF and Alves N (2020) Multi-Material Implants for Temporomandibular Joint Disc Repair: Tailored Additive Manufacturing Production. Front. Bioeng. Biotechnol. 8:342. doi: 10.3389/fbioe.2020.00342
2296-4185
10.3389/fbioe.2020.00342
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137002895966208

Registros relacionados