Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)

Detalhes bibliográficos
Autor(a) principal: Vital, Marcos José Salgado
Data de Publicação: 2015
Outros Autores: Carneiro, Ana Lúcia Basílio, Rocha e Silva, Luiz Francisco, Amorim, Rodrigo César das Neves, Camargo, Marlene Rodrigues Marcelino, Pohlit, Adrian Martin
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188
Resumo: The chemistry and pharmacology literature on Geissospermum is surveyed. Pau-pereira or pao pereira (G. laeve (Vell.) Miers; G. vellosii Fr. All. is a synonym) is the best known of approximately six Geissospermum species. Pau-pereira bark is mainly used for its bitterness and medicinal properties. It is used to treat pain, liver ailments, fevers, appetite loss, indigestion, dizziness, constipation and malaria, among other ailments. The other Geissospermum species have similar traditional uses. Pau-pereira provides monoterpenoid indole alkaloid rich extracts and fractions and pure isolates that comprise formulations used in clinical practice for the treatment of prostate cancer (flavopereirine) and HIV-AIDS (flavopereirine). Also, G. vellosii extracts exhibit pronounced antinociceptive activity in animals (perhaps due to 12-methoxy-1-methylaspidospermine). Induced amnesia in mice is reduced by pau-pereira extracts and geissospermine which also have anticholinesterase activity and potential application against Alzheimer´s Disease. G. argenteum Woodson extracts exhibit in vitro antibacterial activity. Extracts of three Geissospermum species and isolated alkaloids aspidocarpine, flavopereirine, and geissolosimine strongly inhibit the human malaria parasite Plasmodium falciparum Welch in vitro. Two Geissospermum species inhibit Plasmodium yoelii in rodents and exhibit toxicity. Geissospermum extracts and alkaloids inhibit P. falciparum, Leishmania infantum Nicolle and Trypanosoma cruzi Chagas and deserve further study as therapeutic agents.
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spelling Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)Composição química, etnofarmacologia e atividade biológica de espécies de Geissospermum Allemão (Apocynaceae Juss.)pao pereiraanticanceranti-HIVanti-Leishmaniaanti-TrypanosomaantimalarialThe chemistry and pharmacology literature on Geissospermum is surveyed. Pau-pereira or pao pereira (G. laeve (Vell.) Miers; G. vellosii Fr. All. is a synonym) is the best known of approximately six Geissospermum species. Pau-pereira bark is mainly used for its bitterness and medicinal properties. It is used to treat pain, liver ailments, fevers, appetite loss, indigestion, dizziness, constipation and malaria, among other ailments. The other Geissospermum species have similar traditional uses. Pau-pereira provides monoterpenoid indole alkaloid rich extracts and fractions and pure isolates that comprise formulations used in clinical practice for the treatment of prostate cancer (flavopereirine) and HIV-AIDS (flavopereirine). Also, G. vellosii extracts exhibit pronounced antinociceptive activity in animals (perhaps due to 12-methoxy-1-methylaspidospermine). Induced amnesia in mice is reduced by pau-pereira extracts and geissospermine which also have anticholinesterase activity and potential application against Alzheimer´s Disease. G. argenteum Woodson extracts exhibit in vitro antibacterial activity. Extracts of three Geissospermum species and isolated alkaloids aspidocarpine, flavopereirine, and geissolosimine strongly inhibit the human malaria parasite Plasmodium falciparum Welch in vitro. Two Geissospermum species inhibit Plasmodium yoelii in rodents and exhibit toxicity. Geissospermum extracts and alkaloids inhibit P. falciparum, Leishmania infantum Nicolle and Trypanosoma cruzi Chagas and deserve further study as therapeutic agents.A literatura de química e farmacologia sobre Geissospermum é revisada. Pau-pereira ou pao pereira (G. laeve (Vell.) Miers; G. vellosii Fr. All. é sinonímio) é a mais conhecida de aproximadamente seis espécies de Geissospermum. A casca de pau-pereira é usada principalmente por sua amargura e propriedades medicinais. É usada para tratar dor, doenças de fígado, febres, perda de apetite, mal-digestão, tontura, prisão de ventre e malária, entre outras enfermidades. A outra espécie de Geissospermum tem usos tradicionais semelhantes. Pau-pereira é fonte de alcaloides indólicos monoterpenoídicos isolados e extratos e frações enriquecidos nesses alcaloides que são utilizados na clínica médica para o tratamento do câncer de próstata (flavopereirina) e HIV-AIDS (flavopereirina). Também, os extratos de G. vellosii exibem atividade antinociceptíva em animais (talvez devido a 12-metoxi-1-metilaspidospermina). Amnesia induzida em camundongos é reduzida por extratos de pau-pereira e geissospermina que também possuem atividade anticolinesterase e aplicação potencial contra o mal de Alzheimer. Extratos de G. argenteum Woodson exibem atividade antibacteriana. Extratos de três espécies de Geissospermum e os alcaloides isolados aspidocarpina, flavopereirina e geissolosimina inibem fortemente o parasito da malária humana Plasmodium falciparum Welch in vitro. Duas espécies de Geissospermum inibem Plasmodium yoelii em roedores e exibem toxicidade. Os extratos de Geissospermum e alcaloides inibem P. falciparum, Leishmania infantum Nicolle e Trypanosoma cruzi Chagas e merecem estudos futuros como agentes terapêuticos.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2015-01-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/18810.5935/1808-9569.20130002Revista Fitos; Vol. 8 No. 2 (2013); 137-146Revista Fitos; Vol. 8 Núm. 2 (2013); 137-146Revista Fitos; v. 8 n. 2 (2013); 137-1462446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZengporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188/pdf_2https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188/1143Copyright (c) 2016 Revista Fitos Eletrônicainfo:eu-repo/semantics/openAccessVital, Marcos José SalgadoCarneiro, Ana Lúcia BasílioRocha e Silva, Luiz FranciscoAmorim, Rodrigo César das NevesCamargo, Marlene Rodrigues MarcelinoPohlit, Adrian Martin2022-08-26T16:16:25Zoai:ojs.revistafitos.far.fiocruz.br:article/188Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-08-26T16:16:25Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
Composição química, etnofarmacologia e atividade biológica de espécies de Geissospermum Allemão (Apocynaceae Juss.)
title Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
spellingShingle Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
Vital, Marcos José Salgado
pao pereira
anticancer
anti-HIV
anti-Leishmania
anti-Trypanosoma
antimalarial
title_short Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
title_full Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
title_fullStr Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
title_full_unstemmed Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
title_sort Chemical composition, ethnopharmacology and biological activity of Geissospermum Allemão species (Apocynaceae Juss.)
author Vital, Marcos José Salgado
author_facet Vital, Marcos José Salgado
Carneiro, Ana Lúcia Basílio
Rocha e Silva, Luiz Francisco
Amorim, Rodrigo César das Neves
Camargo, Marlene Rodrigues Marcelino
Pohlit, Adrian Martin
author_role author
author2 Carneiro, Ana Lúcia Basílio
Rocha e Silva, Luiz Francisco
Amorim, Rodrigo César das Neves
Camargo, Marlene Rodrigues Marcelino
Pohlit, Adrian Martin
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vital, Marcos José Salgado
Carneiro, Ana Lúcia Basílio
Rocha e Silva, Luiz Francisco
Amorim, Rodrigo César das Neves
Camargo, Marlene Rodrigues Marcelino
Pohlit, Adrian Martin
dc.subject.por.fl_str_mv pao pereira
anticancer
anti-HIV
anti-Leishmania
anti-Trypanosoma
antimalarial
topic pao pereira
anticancer
anti-HIV
anti-Leishmania
anti-Trypanosoma
antimalarial
description The chemistry and pharmacology literature on Geissospermum is surveyed. Pau-pereira or pao pereira (G. laeve (Vell.) Miers; G. vellosii Fr. All. is a synonym) is the best known of approximately six Geissospermum species. Pau-pereira bark is mainly used for its bitterness and medicinal properties. It is used to treat pain, liver ailments, fevers, appetite loss, indigestion, dizziness, constipation and malaria, among other ailments. The other Geissospermum species have similar traditional uses. Pau-pereira provides monoterpenoid indole alkaloid rich extracts and fractions and pure isolates that comprise formulations used in clinical practice for the treatment of prostate cancer (flavopereirine) and HIV-AIDS (flavopereirine). Also, G. vellosii extracts exhibit pronounced antinociceptive activity in animals (perhaps due to 12-methoxy-1-methylaspidospermine). Induced amnesia in mice is reduced by pau-pereira extracts and geissospermine which also have anticholinesterase activity and potential application against Alzheimer´s Disease. G. argenteum Woodson extracts exhibit in vitro antibacterial activity. Extracts of three Geissospermum species and isolated alkaloids aspidocarpine, flavopereirine, and geissolosimine strongly inhibit the human malaria parasite Plasmodium falciparum Welch in vitro. Two Geissospermum species inhibit Plasmodium yoelii in rodents and exhibit toxicity. Geissospermum extracts and alkaloids inhibit P. falciparum, Leishmania infantum Nicolle and Trypanosoma cruzi Chagas and deserve further study as therapeutic agents.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188
10.5935/1808-9569.20130002
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188
identifier_str_mv 10.5935/1808-9569.20130002
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188/pdf_2
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/188/1143
dc.rights.driver.fl_str_mv Copyright (c) 2016 Revista Fitos Eletrônica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 Revista Fitos Eletrônica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 8 No. 2 (2013); 137-146
Revista Fitos; Vol. 8 Núm. 2 (2013); 137-146
Revista Fitos; v. 8 n. 2 (2013); 137-146
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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