Evaluation of the antioxidant activity of Hibiscus sabdariffa L. extract for the development of a cosmetic formulation

• Autor(a) principal: Sousa, José Maria Aguiar
• Data de Publicação: 2021
• Outros Autores: Caldas, Jeanne Marques, Brito, Maria Cristiane Aranha
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1110
• topic: Antioxidante; Fitocosmético; Metabólitos secundários; Plantas medicinais; Toxicidade; Antioxidante; Fitocosmético; Metabolitos secundarios; Plantas medicinales; Toxicidad; Antioxidant; Medicinal plant; Phytocosmetics; Secondary metabolites; Toxicity

Hibiscus sabdariffa L, belongs to the Malvaceae family, having antioxidant characters of interest to the pharmaceutical industry. This work aimed to develop a cosmetic formulation based on the extract of Hibiscus sabdariffa L, highlighting its antioxidant activity. The methodology of this material is based on the phytochemical analysis of the extract, evaluation of toxicity against Artemia salina and, finally, stability tests of the formulations. Within the main results, phytochemical tests demonstrated the presence of alkaloids, flavonoids and tannins, whereas with regard to the total polyphenol content, the average with the highest content was that of the hydromodule 1: 8 with 0.875 (mgGA) / g. The extract found with the least toxicity was the 1:10 hydromodule with the LC50 value found of ± 29270.3 µL / mL. The most stable formulation was that with a 14% lanette concentration in a 15-day analysis. Therefore, the 1:10 hydromodule has an advantage with regard to the choice for the production of the pharmaceutical formulation containing the extract of Hibiscus sabdariffa, judging by its lower toxicity and its capacity as an antioxidant.