Solid dispersions of leaves Eugenia florida (Myrtaceae) extracts to optimize the solubility of the betulinic acid marker

• Autor(a) principal: Nóbrega, Andréa Bezerra da
• Data de Publicação: 2021
• Outros Autores: Bizarri, Carlos Henrique Brasil, Paz, Andressa Santana, Seiceira, Rafael Cardoso, Conceição, Edemilson Cardoso da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1070
• topic: Dispersões Sólidas; Solubilidade; Ácido Betulínico; Eugenia florida; Solid Dispersions; Solubility; Betulinic Acid; Eugenia florida

Eugenia florida DC belongs to the family Myrtaceae. Previous phytochemical studies with extracts of E. florida leaves showed the occurrence of triterpenes and, among its constituents, the betulinic acid (BA), which presents a vast literature with different biological activities, such as anti-inflammatory, antimalarial, antimicrobial, antiviral and anticancer, however, its low aqueous solubility limits its bioavailability. In order to increase bioavailability, the use of solid dispersions is highlighted, where lipophilic drugs are dispersed in hydrophilic carriers, causing increase in solubility and dissolution profile. In this work, solid dispersions containing extracts of E. florida were prepared using the carrier Gelucire®50/13 as a polymeric agent and lactose monohydrate as a hydrophilic support using the fusion technique. The system that showed better BA solubility was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and X-Ray Diffractometry (DRX). The solid dispersion technique elevated the solubility of betulinic acid in Eugenia florida leaf extract eleven times, suggesting an increase in the bioavailability of the marker.