Piper aduncum L.: Pluripotente Plant and Important Phytochemical Substance Source

• Autor(a) principal: Pohlit, A. M.
• Data de Publicação: 2006
• Outros Autores: Pinto, A. C. S., Mause, R.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/37
• topic: Piper aduncum; dilapiol; óleo essencial; atividade biológica; sinergismo; Piper aduncum; dillapiol; essential oil; biological activities; synergism

This review deals with the primary biological activities and previously isolated active principles from pimenta-longa (long pepper) or apertaruão, the Piper aduncum L. (Piperaceae). Among the most important biological activities found in extracts and for isolated substances are: antibacterial, antifungal, antioxidant, cytotoxic/anticancer, larvicidal/insecticidal, antiplatelet/antiaggregation, molusidal, leishmanicidal end antiviral. This endemic plant is found naturally in Brazil and is a source of a relatively abundant essential oil obtained from the leaves and tender branches. This oil presents many of the above biological activities and medicinal properties. Here in we present our data on pilot-scale production of this oil as well as the purification of the principal component dillapiol using chromatography and fractional vacuum distillation from this oil. This work demonstrates the technical viability of cultivated P. aduncum as a renewable source of this bioactive substance. Among the proven biological activities of this compound are: antibacterial, insecticida and larvicidal, as well as inhibition of the enzymes cytochrome P450 and epoxidase.