Natural Product-based Drug Discovery and the Molecular Power House (MPH) Approach

• Autor(a) principal: Trivella, Daniela Barretto Barbosa
• Data de Publicação: 2022
• Outros Autores: Bruder, Marjorie Christine Paule, Oliveira, Fábio Cesar Bonafé, Porcaro, Renata, Rustiguel, Joane Kathelen, Ribeiro, Leonardo Bergamasco, Felicio, Rafael de, Cunha, Marcos Guilherme da, Nascimento, Andrey Fabricio Ziem, Zeri, Ana Carolina Mattos, Pessa, Lisandra Ravanelli, Mascarello, Alessandra, Guimarães, Cristiano Ruch Werneck, Azevedo, Hatylas, Perfeito, Marcia Luana Gomes, Pagani, Eduardo, Ropke, Cristina Dislich
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1346
• topic: Descoberta e Desenvolvimento de Fármacos; Produtos Naturais; Biodiversidade Brasileira; Molecular Power House; Cristalografia; Metabolômica; Drug Discovery and Development; Natural Products; Brazilian Biodiversity; Power House; Crystallography; Metabolomics

Natural product-based drug discovery is experiencing a new era thanks to the use of cutting-edge technologies and integrated approaches to overcome the difficulties inherent to natural products research. These are highly complex and innovative chemical substances produced by the biota, in particular sessile organisms such as plants and microorganisms, and represent the main source of inspiration for new drugs. The increasing interest in the discovery of medicines based on natural products has pushed the development of new approaches for the identification, characterization and resupply of natural products, which can address some of the challenges related to the development of drugs inspired by molecules from the biodiversity. The aim is to detect and characterize new bioactive natural products, at the same time as reducing costs and time to obtain these molecules. For this, it is necessary to innovate in the processes and technologies applied to the discovery of drugs from natural products. The Molecular Power House (MPH) approach presented in this work makes use of integrated technologies as a way to overcome classic bottlenecks in plant natural products research, which aligned with access to the greatest biodiversity on the planet, positions Brazil in the global scenario of discovering innovative drugs.