Antimicrobial activity of polyphenols isolated from the leaves of Schinopsis brasiliensis (Engl.) guided by bioautography

• Autor(a) principal: Saraiva, Antonio Marcos
• Data de Publicação: 2020
• Outros Autores: Coutinho, Felipe Neves, da Silva, Ricardo Oliveira, Randau, Karina Perrelli, Xavier, Haroudo Satiro, Pisciottano, Maria Nelly Caetano
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/850
• topic: β-1,2,3,4,6-Pentagaloyl-D-Glucose;; Staphylococcus aureus multiresistant MRSA; Pseudomonas aeruginosa;; Bioautography.; β-1,2,3,4,6-Pentagaloil-D-Glicose;; Staphylococcus aureus MRSA multirresistente; Pseudomonas aeruginosa;; Bioautografia.

The methanolic extract of the leaves of Schinopsis brasiliensis presented antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus saprophyticus with minimum inhibitory concentration of 31.15 μg/mL. Phytochemical prospecting of Schinopsis brasiliensis (leaves.) guided by the bioautographic method allowed to isolate two molecules (methyl gallate - GM and β-1,2,3,4,6-PentaGaloil-D-Glucose - PGG), which showed antimicrobial activity against S. aureus, coagulase-negative staphylococci and Enterococcus faecalis with inhibition zones of 14 to 20 mm. Furthermore, PGG presented antimicrobial activity against Pseudomonas aeruginosa showed inhibition zone of 21 mm and GM showed inhibition zone of 17 to 18 mm against Escherichia coli. Further studies, such as quantification of antimicrobial compounds and identification of other secondary metabolites of leaves of S. brasiliensis are necessary due to the present results.