Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities

Detalhes bibliográficos
Autor(a) principal: Cruz, Maria de Fátima Simão Jucá
Data de Publicação: 2023
Outros Autores: Pereira, Gabriela Moysés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351
Resumo: Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.
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spelling Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilitiesRelação estrutura-atividade de saponinas triterpenoidais: propriedades biológicas e aplicabilidades comerciaisTriterpenoid saponinsMedicinal chemistryTherapeutics propertiesVaccineCOVID-19Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.As saponinas são tensoativos não iônicos derivados de plantas e amplamente aplicados em diversos produtos, como cosméticos, desinfetantes, medicamentos, vacinas, como aditivos por propriedades terapêuticas e características químicas próprias. Essas substâncias são de crescente interesse para a pesquisa de medicamentos, pois são constituintes ativos de diversos medicamentos populares, além de comporem uma importante classe da química medicinal. As saponinas triterpenoidais são metabólitos secundários, amplamente distribuídos nas espécies vegetais e caracterizam-se como um dos princípios ativos destas. Estas saponinas possuem potentes atividades antiviral, adjuvante, hemolítica, citotóxica e antiangiogênica que estão relacionadas com a presença de fração química característica. Neste trabalho foram resumidos os estudos encontrados na literatura científica sobre as propriedades terapêuticas das saponinas triterpenoidais, bem como a sua aplicabilidade comercial. Trabalhos recentes sugeriram algumas saponinas triterpenoidais como candidatas ao tratamento de pacientes com COVID-19.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2023-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmltext/xmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/135110.32712/2446-4775.2022.1351Revista Fitos; Vol. 17 No. 2 (2023); 295-316Revista Fitos; Vol. 17 Núm. 2 (2023); 295-316Revista Fitos; v. 17 n. 2 (2023); 295-3162446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1327https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1328https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1462Copyright (c) 2023 Revista Fitoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCruz, Maria de Fátima Simão Jucá Pereira, Gabriela Moysés2024-01-08T19:29:35Zoai:ojs.revistafitos.far.fiocruz.br:article/1351Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2024-01-08T19:29:35Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
Relação estrutura-atividade de saponinas triterpenoidais: propriedades biológicas e aplicabilidades comerciais
title Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
spellingShingle Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
Cruz, Maria de Fátima Simão Jucá
Triterpenoid saponins
Medicinal chemistry
Therapeutics properties
Vaccine
COVID-19
title_short Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
title_full Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
title_fullStr Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
title_full_unstemmed Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
title_sort Structure-activity relationship of triterpenoid saponins: Biological properties and commercial applicabilities
author Cruz, Maria de Fátima Simão Jucá
author_facet Cruz, Maria de Fátima Simão Jucá
Pereira, Gabriela Moysés
author_role author
author2 Pereira, Gabriela Moysés
author2_role author
dc.contributor.author.fl_str_mv Cruz, Maria de Fátima Simão Jucá
Pereira, Gabriela Moysés
dc.subject.por.fl_str_mv Triterpenoid saponins
Medicinal chemistry
Therapeutics properties
Vaccine
COVID-19
topic Triterpenoid saponins
Medicinal chemistry
Therapeutics properties
Vaccine
COVID-19
description Saponins are plant-derived non-ionic surfactants and widely applied in many products, such as cosmetics, cleansers, medicines, vaccine, as additives by therapeutic properties and chemical characteristics theirs. These substances are of growing interest for drug research as they’re active constituents of several folk medicines, in addition to comprising an important class of medicinal chemistry. Triterpenoid saponins are secondary metabolites, these’re largely distributed in plant species and they’re characterized as one of the active principles of these. These saponins have potent anti-viral, adjuvant, hemolytic, cytotoxic and anti-angiogenic activities that are relationship with the presence of characteristics chemical moiety. In this work was summarized the studies found in the scientific literature on the therapeutic properties of triterpenoid saponins, as well as commercial applicability theirs. Recent works have suggested some triterpenoid saponins like candidates for treatment of patients with COVID-19.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351
10.32712/2446-4775.2022.1351
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351
identifier_str_mv 10.32712/2446-4775.2022.1351
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1327
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1328
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1351/1462
dc.rights.driver.fl_str_mv Copyright (c) 2023 Revista Fitos
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Revista Fitos
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
text/xml
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 17 No. 2 (2023); 295-316
Revista Fitos; Vol. 17 Núm. 2 (2023); 295-316
Revista Fitos; v. 17 n. 2 (2023); 295-316
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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