Plant therapeutic proteases: chemical aspects, applications and pharmaceutical formulation

• Autor(a) principal: Silva-López, Raquel Elisa
• Data de Publicação: 2024
• Outros Autores: Ferreira, Patrícia Fernandes
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/914
• topic: Enzimas de planta; Proteases terapêuticas; Imobilização; Formulação; Enzimas vegetales; Proteasas terapéuticas; Inmobilización; Formulación; Plant enzymes; Therapeutic protease; Immobilization; Formulation

Proteases are enzymes that cleave peptide bonds in proteins and peptides. Are found in all living organisms and mediate many crucial functions. These enzymes have been used by man since antiquity for various purposes such as food processing and treatment of various diseases. Plants are important sources of proteases with significant activity and high thermal stability and in the presence of various chemical agents. Such requirements are essential to your pharmacological employment. Many such as papain, bromelain and phytin are marketed to treat cases of respiratory and digestive insufficiency, parasitic infections and wound healing. Therapeutic proteases are very specific and efficient; however, they have very complex structures, and their maintenance requires very specific conditions to guarantee their biological / pharmacological activities. Therefore, their formulations are designed to stabilize their structure / activity, protect against degradation, improve their pharmacokinetics, prolong their action, reduce their toxic effects and direct them to their therapeutic target. Nanotechnology has made it possible to build drug carriers, including polymeric nano / microparticles: hydrogels, dendrimers, liposomes that are capable of increasing efficacy, clinical applicability and patient compliance. Such biodegradable / biocompatible polymers are promising carriers of these therapeutic plant proteases.