Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Fitos |
Texto Completo: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567 |
Resumo: | The consumption of Aloe vera (L.) Burm.f. (A. vera) may present serious health risks. The objective of this study was to assess the available information on hepatotoxicity cases following the ingestion of A. vera preparations by means of an integrative literature review. Thus, using the descriptors "hepatitis AND Aloe" and "liver AND Aloe", a search through PubMed, Scopus and Web of Science databases yielded eight papers for review. Hepatotoxicity cases, as reported by such studies, concerned mostly women (70%) – only 30% of individuals thus intoxicated were elderly and 80% of them had no comorbidities. Self-medication was the most reported exposure circumstance (60%). Chronic or subchronic exposures were most frequent (90%), the development of hepatocellular lesions being reported as equally prevalent (90%). All cases were classified as probable or definite using the Roussel Uclaf Causality Assessment Method. Interestingly, the discontinuation of use yielded a cure in all patients, thus allowing for the conclusion that A. vera was the agent responsible for hepatotoxicity in all cases. Such results emphasize the importance of expert professional guidance when using herbal preparations. |
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Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative reviewHepatotoxicidade causada após uso oral de Aloe vera (L.) Burm. f. (Asphodelaceae): revisão integrativaHepatic InsufficiencyAloeDietary supplementsMedicinal plantsToxicologyInsuficiência hepáticaAloeSuplementos nutricionaisPlantas medicinaisToxicologiaThe consumption of Aloe vera (L.) Burm.f. (A. vera) may present serious health risks. The objective of this study was to assess the available information on hepatotoxicity cases following the ingestion of A. vera preparations by means of an integrative literature review. Thus, using the descriptors "hepatitis AND Aloe" and "liver AND Aloe", a search through PubMed, Scopus and Web of Science databases yielded eight papers for review. Hepatotoxicity cases, as reported by such studies, concerned mostly women (70%) – only 30% of individuals thus intoxicated were elderly and 80% of them had no comorbidities. Self-medication was the most reported exposure circumstance (60%). Chronic or subchronic exposures were most frequent (90%), the development of hepatocellular lesions being reported as equally prevalent (90%). All cases were classified as probable or definite using the Roussel Uclaf Causality Assessment Method. Interestingly, the discontinuation of use yielded a cure in all patients, thus allowing for the conclusion that A. vera was the agent responsible for hepatotoxicity in all cases. Such results emphasize the importance of expert professional guidance when using herbal preparations.O consumo da Aloe vera (L.) Burm. f. (A. vera) pode causar riscos à saúde. Assim, o objetivo deste trabalho consistiu em identificar e apresentar, a partir de uma revisão integrativa da literatura, as informações disponíveis sobre casos de hepatotoxicidade ocorridos após a ingestão de preparações de A. vera. A busca foi feita nas bases de dados PubMed, Scopus e Web of Science, com os descritores “hepatitis AND Aloe” e “liver AND Aloe”, e oito artigos foram incluídos na revisão. Os indivíduos envolvidos nos relatos de casos de hepatotoxicidade aqui analisados eram, em sua maioria, mulheres (70%); apenas 30% eram idosos e 80% não apresentavam comorbidades. A automedicação foi a circunstância de exposição mais relatada (60%). Exposições do tipo crônica ou subcrônica foram as mais frequentes (90%), bem como o desenvolvimento de lesão do tipo hepatocelular (90%). Todos os casos receberam a classificação Roussel Uclaf Causality Assessment Method como provável ou definida. Curiosamente, a suspensão do uso gerou a cura de todos os pacientes. Concluiu-se, assim, que A. vera foi o agente responsável pela hepatotoxicidade em todos os casos, o que enfatiza a importância de uma orientação profissional especializada ao se utilizar preparações à base de plantas.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2024-01-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/156710.32712/2446-4775.2024.1567Revista Fitos; Vol. 18 (2024); e1567Revista Fitos; Vol. 18 (2024); e1567Revista Fitos; v. 18 (2024); e15672446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567/1470https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567/1471Copyright (c) 2024 Revista Fitoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Silva, Hendyelle Rodrigues Ferreira e Passos, Ana Cláudia de Brito Ferreira, Maria Augusta Drago2024-03-07T19:50:24Zoai:ojs.revistafitos.far.fiocruz.br:article/1567Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2024-03-07T19:50:24Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review Hepatotoxicidade causada após uso oral de Aloe vera (L.) Burm. f. (Asphodelaceae): revisão integrativa |
title |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
spellingShingle |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review Silva, Hendyelle Rodrigues Ferreira e Hepatic Insufficiency Aloe Dietary supplements Medicinal plants Toxicology Insuficiência hepática Aloe Suplementos nutricionais Plantas medicinais Toxicologia |
title_short |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
title_full |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
title_fullStr |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
title_full_unstemmed |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
title_sort |
Hepatotoxicity caused after oral use of Aloe vera (L.) Burm. f. (Asphodelaceae): an integrative review |
author |
Silva, Hendyelle Rodrigues Ferreira e |
author_facet |
Silva, Hendyelle Rodrigues Ferreira e Passos, Ana Cláudia de Brito Ferreira, Maria Augusta Drago |
author_role |
author |
author2 |
Passos, Ana Cláudia de Brito Ferreira, Maria Augusta Drago |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva, Hendyelle Rodrigues Ferreira e Passos, Ana Cláudia de Brito Ferreira, Maria Augusta Drago |
dc.subject.por.fl_str_mv |
Hepatic Insufficiency Aloe Dietary supplements Medicinal plants Toxicology Insuficiência hepática Aloe Suplementos nutricionais Plantas medicinais Toxicologia |
topic |
Hepatic Insufficiency Aloe Dietary supplements Medicinal plants Toxicology Insuficiência hepática Aloe Suplementos nutricionais Plantas medicinais Toxicologia |
description |
The consumption of Aloe vera (L.) Burm.f. (A. vera) may present serious health risks. The objective of this study was to assess the available information on hepatotoxicity cases following the ingestion of A. vera preparations by means of an integrative literature review. Thus, using the descriptors "hepatitis AND Aloe" and "liver AND Aloe", a search through PubMed, Scopus and Web of Science databases yielded eight papers for review. Hepatotoxicity cases, as reported by such studies, concerned mostly women (70%) – only 30% of individuals thus intoxicated were elderly and 80% of them had no comorbidities. Self-medication was the most reported exposure circumstance (60%). Chronic or subchronic exposures were most frequent (90%), the development of hepatocellular lesions being reported as equally prevalent (90%). All cases were classified as probable or definite using the Roussel Uclaf Causality Assessment Method. Interestingly, the discontinuation of use yielded a cure in all patients, thus allowing for the conclusion that A. vera was the agent responsible for hepatotoxicity in all cases. Such results emphasize the importance of expert professional guidance when using herbal preparations. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567 10.32712/2446-4775.2024.1567 |
url |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567 |
identifier_str_mv |
10.32712/2446-4775.2024.1567 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567/1470 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1567/1471 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Revista Fitos https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Revista Fitos https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html |
dc.publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
dc.source.none.fl_str_mv |
Revista Fitos; Vol. 18 (2024); e1567 Revista Fitos; Vol. 18 (2024); e1567 Revista Fitos; v. 18 (2024); e1567 2446-4775 1808-9569 reponame:Revista Fitos instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Revista Fitos |
collection |
Revista Fitos |
repository.name.fl_str_mv |
Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br |
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