Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)

Detalhes bibliográficos
Autor(a) principal: Brandão, Geraldo Célio
Data de Publicação: 2015
Outros Autores: Kroon, Erna G, Matos, Allan W, Filho, José D. Souza, Oliveira, Alaíde B
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207
Resumo: Xylophragma Sprague species (family Bignoniaceae Juss.) are climbing plants belonging to the tribe Bignonieae Juss. and some species have a wide spectrum of traditional medicinal uses including remedies for the treatment of infections. This paper reports the bioguided fractionation of an ethanol extract of X. myrianthum (Cham.) Sprague stems (EEXMS) for antiviral effects against human herpes virus type 1 (HSV-1), dengue virus 2 (DENV-2), murine encephalomyocarditis virus (EMCV) and vaccinia virus (VACV) that afforded XM-1 as an active compound. Spectroscopic analyses allowed the identification of XM-1 as arjunic acid whose occurrence in the Bignoniaceae and anti-DENV-2 activities are reported for the first time. X. myrianthum is revealed herein as a source of an antiviral compound and fractions.
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spelling Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)TriterpeneArjunic acidMTT assayXylophragma Sprague species (family Bignoniaceae Juss.) are climbing plants belonging to the tribe Bignonieae Juss. and some species have a wide spectrum of traditional medicinal uses including remedies for the treatment of infections. This paper reports the bioguided fractionation of an ethanol extract of X. myrianthum (Cham.) Sprague stems (EEXMS) for antiviral effects against human herpes virus type 1 (HSV-1), dengue virus 2 (DENV-2), murine encephalomyocarditis virus (EMCV) and vaccinia virus (VACV) that afforded XM-1 as an active compound. Spectroscopic analyses allowed the identification of XM-1 as arjunic acid whose occurrence in the Bignoniaceae and anti-DENV-2 activities are reported for the first time. X. myrianthum is revealed herein as a source of an antiviral compound and fractions.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2015-01-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/20710.5935/1808-9569.20130007Revista Fitos; Vol. 8 No. 2 (2013); 125-136Revista Fitos; Vol. 8 Núm. 2 (2013); 125-136Revista Fitos; v. 8 n. 2 (2013); 125-1362446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZengporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207/pdf_50https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207/1142Copyright (c) 2016 Revista Fitos Eletrônicainfo:eu-repo/semantics/openAccessBrandão, Geraldo CélioKroon, Erna GMatos, Allan WFilho, José D. SouzaOliveira, Alaíde B2022-08-26T16:14:23Zoai:ojs.revistafitos.far.fiocruz.br:article/207Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-08-26T16:14:23Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
title Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
spellingShingle Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
Brandão, Geraldo Célio
Triterpene
Arjunic acid
MTT assay
title_short Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
title_full Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
title_fullStr Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
title_full_unstemmed Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
title_sort Bioguided isolation of an antiviral compound from Xylophragma myrianthum (Cham.) Sprague (Bignoniaceae Juss.)
author Brandão, Geraldo Célio
author_facet Brandão, Geraldo Célio
Kroon, Erna G
Matos, Allan W
Filho, José D. Souza
Oliveira, Alaíde B
author_role author
author2 Kroon, Erna G
Matos, Allan W
Filho, José D. Souza
Oliveira, Alaíde B
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brandão, Geraldo Célio
Kroon, Erna G
Matos, Allan W
Filho, José D. Souza
Oliveira, Alaíde B
dc.subject.por.fl_str_mv Triterpene
Arjunic acid
MTT assay
topic Triterpene
Arjunic acid
MTT assay
description Xylophragma Sprague species (family Bignoniaceae Juss.) are climbing plants belonging to the tribe Bignonieae Juss. and some species have a wide spectrum of traditional medicinal uses including remedies for the treatment of infections. This paper reports the bioguided fractionation of an ethanol extract of X. myrianthum (Cham.) Sprague stems (EEXMS) for antiviral effects against human herpes virus type 1 (HSV-1), dengue virus 2 (DENV-2), murine encephalomyocarditis virus (EMCV) and vaccinia virus (VACV) that afforded XM-1 as an active compound. Spectroscopic analyses allowed the identification of XM-1 as arjunic acid whose occurrence in the Bignoniaceae and anti-DENV-2 activities are reported for the first time. X. myrianthum is revealed herein as a source of an antiviral compound and fractions.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207
10.5935/1808-9569.20130007
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207
identifier_str_mv 10.5935/1808-9569.20130007
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207/pdf_50
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/207/1142
dc.rights.driver.fl_str_mv Copyright (c) 2016 Revista Fitos Eletrônica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 Revista Fitos Eletrônica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 8 No. 2 (2013); 125-136
Revista Fitos; Vol. 8 Núm. 2 (2013); 125-136
Revista Fitos; v. 8 n. 2 (2013); 125-136
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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