Evaluation of in vitro antileishmanial and antimycobacterial activities of Stifftia chrysantha J.C. Mikan extracts

• Autor(a) principal: Marques, André M.
• Data de Publicação: 2012
• Outros Autores: Machado, Rachel R. P., Júnior, Wilson Valente, Coimbra, Elaine S., Duarte, Rafael S., Soares, Geraldo Luiz G., Kaplan, Maria Auxiliadora C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/162
• topic: Stifftia chrysantha; Diadem; Methyl salicilate; Mycobacterium bovis; Mycobacterium smegmatis; Leishmaniasis; Stifftia chrysantha; Diadem; Methyl salicilate; Mycobacterium bovis; Mycobacterium smegmatis; Leishmaniasis

Stifftia chrysantha J.C. Mikan is a plant that belongs to Asteraceae family, mainly used for ornamental purposes and it is moderately endangered to die out nowadays. It is known this plant has been used on the treatment of respiratory affections by quilombo communities (Brazilian hinterland settlement founded by people of African origin). The aim of this study was to investigate the potential antimicrobial effect of different extracts from S. chrysantha against some species of mycobacterias and promastigote forms of two Leishmania sp. In vitro assays were performed using colorimetric methods with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide or Resazurin, according to the microorganism evaluated. The results showed low activity of extracts against mycobacterial cultures. On the other hand, a growth inhibitory effect was observed in the methanol extract from leaves and on the hexane extract from bark against promastigote culture of L. amazonensis (IC50 = 55.16 mg/ml methanol extract and 38.61mg/ml hexane extract) and L. chagasi (IC50 = 72.05 mg/ml hexane extract). New studies are necessary to discover the substances that were responsible for the growth inhibition of promastigote forms.