Natural Products and Apoptosis: a Promising Approach for Drug Discovery

Detalhes bibliográficos
Autor(a) principal: Costa, S. S.
Data de Publicação: 2006
Outros Autores: Muzitano, M. F.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52
Resumo: The programmed cell death, also called apoptosis, is part of several vital processes, as the embryonic development, the control of tumors and the regulation of populations of cells of the immune system. Disturbs of its regulation are involved with a variety of illnesses such as AIDS, cancer, Alzheimer's, autoimmune diseases and Parkinson's disease. Today we have access to several studies showing in a deep way the direct effect of molecules on therapeutic targets in apoptotic mechanisms that could be used in the treatment of some incurable illnesses. The most promising results in this area concern, for example, substances obtained from garlic (Allium sativum), terpenes from Caseria membranaceae and Zingiber mioga and derivatives of gambogic acid, isolated from Garcinia hurburyi. Many efforts have been made to apply apoptosis inducer drugs in cancer therapy, but few studies have been correlated to other illnesses. The aim of this review is to show the potential of natural molecules to the treatment of cancer and those other pathologies, based on the most studied apoptosis therapeutic targets.
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spelling Natural Products and Apoptosis: a Promising Approach for Drug DiscoveryProdutos Naturais e a Apoptose: Um Enfoque Promissor para a Descoberta de Novos Fármacosapoptosismedicinal plantsnatural productsbioactive moleculescaspasesBcl-2apoptoseplantas medicinaisprodutos naturaismoléculas bioativascaspasesBcl-2The programmed cell death, also called apoptosis, is part of several vital processes, as the embryonic development, the control of tumors and the regulation of populations of cells of the immune system. Disturbs of its regulation are involved with a variety of illnesses such as AIDS, cancer, Alzheimer's, autoimmune diseases and Parkinson's disease. Today we have access to several studies showing in a deep way the direct effect of molecules on therapeutic targets in apoptotic mechanisms that could be used in the treatment of some incurable illnesses. The most promising results in this area concern, for example, substances obtained from garlic (Allium sativum), terpenes from Caseria membranaceae and Zingiber mioga and derivatives of gambogic acid, isolated from Garcinia hurburyi. Many efforts have been made to apply apoptosis inducer drugs in cancer therapy, but few studies have been correlated to other illnesses. The aim of this review is to show the potential of natural molecules to the treatment of cancer and those other pathologies, based on the most studied apoptosis therapeutic targets.A morte celular programada, denominada apoptose celular, faz parte de diversos processos vitais, dentre os quais podemos citar o desenvolvimento embrionário, o controle de tumores e a regulação de populações de células do sistema imune. Distúrbios na regulação da apoptose estão envolvidos em uma variedade de doenças, tais como a Síndrome da Imunodeficiência Adquirida (AIDS), o câncer, a doença de Alzheimer, o mal de Parkinson e as doenças auto-imunes. Hoje há acesso a estudos bastante aprofundados sobre moléculas que atuam diretamente em alvos terapêuticos nos mecanismos apoptóticos e que, por esta razão, poderiam ser utilizadas no tratamento de várias doenças ainda sem cura. Os trabalhos mais promissores nesta área focalizam, por exemplo, substâncias isoladas do alho (Allium sativum), terpenos de Caseria membranaceae e de Zingiber mioga, além de alguns produtos do ácido gambógico, isolado de Garcinia hurburyi. Muitos esforços têm sido empregados visando aplicar moléculas capazes de induzir a apoptose no tratamento do câncer, entretanto são poucos os trabalhos direcionados a outras doenças. Esta revisão tem como objetivo principal mostrar o potencial de moléculas de origem natural para o tratamento do câncer e dessas outras patologias, com base nos mais conhecidos alvos terapêuticos envolvidos na apoptose. Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2006-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/5210.32712/2446-4775.2006.52Revista Fitos; Vol. 2 No. 02 (2006); 46-53Revista Fitos; Vol. 2 Núm. 02 (2006); 46-53Revista Fitos; v. 2 n. 02 (2006); 46-532446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52/pdf_42https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52/1275Copyright (c) 2006 Revista Fitos Eletrônicahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCosta, S. S.Muzitano, M. F.2022-10-31T12:35:07Zoai:ojs.revistafitos.far.fiocruz.br:article/52Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-10-31T12:35:07Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Natural Products and Apoptosis: a Promising Approach for Drug Discovery
Produtos Naturais e a Apoptose: Um Enfoque Promissor para a Descoberta de Novos Fármacos
title Natural Products and Apoptosis: a Promising Approach for Drug Discovery
spellingShingle Natural Products and Apoptosis: a Promising Approach for Drug Discovery
Costa, S. S.
apoptosis
medicinal plants
natural products
bioactive molecules
caspases
Bcl-2
apoptose
plantas medicinais
produtos naturais
moléculas bioativas
caspases
Bcl-2
title_short Natural Products and Apoptosis: a Promising Approach for Drug Discovery
title_full Natural Products and Apoptosis: a Promising Approach for Drug Discovery
title_fullStr Natural Products and Apoptosis: a Promising Approach for Drug Discovery
title_full_unstemmed Natural Products and Apoptosis: a Promising Approach for Drug Discovery
title_sort Natural Products and Apoptosis: a Promising Approach for Drug Discovery
author Costa, S. S.
author_facet Costa, S. S.
Muzitano, M. F.
author_role author
author2 Muzitano, M. F.
author2_role author
dc.contributor.author.fl_str_mv Costa, S. S.
Muzitano, M. F.
dc.subject.por.fl_str_mv apoptosis
medicinal plants
natural products
bioactive molecules
caspases
Bcl-2
apoptose
plantas medicinais
produtos naturais
moléculas bioativas
caspases
Bcl-2
topic apoptosis
medicinal plants
natural products
bioactive molecules
caspases
Bcl-2
apoptose
plantas medicinais
produtos naturais
moléculas bioativas
caspases
Bcl-2
description The programmed cell death, also called apoptosis, is part of several vital processes, as the embryonic development, the control of tumors and the regulation of populations of cells of the immune system. Disturbs of its regulation are involved with a variety of illnesses such as AIDS, cancer, Alzheimer's, autoimmune diseases and Parkinson's disease. Today we have access to several studies showing in a deep way the direct effect of molecules on therapeutic targets in apoptotic mechanisms that could be used in the treatment of some incurable illnesses. The most promising results in this area concern, for example, substances obtained from garlic (Allium sativum), terpenes from Caseria membranaceae and Zingiber mioga and derivatives of gambogic acid, isolated from Garcinia hurburyi. Many efforts have been made to apply apoptosis inducer drugs in cancer therapy, but few studies have been correlated to other illnesses. The aim of this review is to show the potential of natural molecules to the treatment of cancer and those other pathologies, based on the most studied apoptosis therapeutic targets.
publishDate 2006
dc.date.none.fl_str_mv 2006-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52
10.32712/2446-4775.2006.52
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52
identifier_str_mv 10.32712/2446-4775.2006.52
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52/pdf_42
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/52/1275
dc.rights.driver.fl_str_mv Copyright (c) 2006 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2006 Revista Fitos Eletrônica
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 2 No. 02 (2006); 46-53
Revista Fitos; Vol. 2 Núm. 02 (2006); 46-53
Revista Fitos; v. 2 n. 02 (2006); 46-53
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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