Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Fitos |
Texto Completo: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588 |
Resumo: | In this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment. |
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Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruitSchinus terebinthifoliusantifungalantitumorcyclodextrinMalassezia furfurIn this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2018-07-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/58810.5935/2446-4775.20180013Revista Fitos; Vol. 12 No. 2 (2018); 135-146Revista Fitos; Vol. 12 Núm. 2 (2018); 135-146Revista Fitos; v. 12 n. 2 (2018); 135-1462446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588/pdfhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588/htmlCopyright (c) 2018 Revista Fitos Eletrônicainfo:eu-repo/semantics/openAccessde Oliveira, Mariana S.Gontijo, Sávio M.Teixeira, Marina S.Teixeira, Karina I. RosaTakahashi, Jacqueline A.Millan, Rubén Dario SinisterraSegura, María Esperanza Cortés2021-01-29T13:30:48Zoai:ojs.revistafitos.far.fiocruz.br:article/588Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2021-01-29T13:30:48Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
title |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
spellingShingle |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit de Oliveira, Mariana S. Schinus terebinthifolius antifungal antitumor cyclodextrin Malassezia furfur |
title_short |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
title_full |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
title_fullStr |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
title_full_unstemmed |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
title_sort |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
author |
de Oliveira, Mariana S. |
author_facet |
de Oliveira, Mariana S. Gontijo, Sávio M. Teixeira, Marina S. Teixeira, Karina I. Rosa Takahashi, Jacqueline A. Millan, Rubén Dario Sinisterra Segura, María Esperanza Cortés |
author_role |
author |
author2 |
Gontijo, Sávio M. Teixeira, Marina S. Teixeira, Karina I. Rosa Takahashi, Jacqueline A. Millan, Rubén Dario Sinisterra Segura, María Esperanza Cortés |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
de Oliveira, Mariana S. Gontijo, Sávio M. Teixeira, Marina S. Teixeira, Karina I. Rosa Takahashi, Jacqueline A. Millan, Rubén Dario Sinisterra Segura, María Esperanza Cortés |
dc.subject.por.fl_str_mv |
Schinus terebinthifolius antifungal antitumor cyclodextrin Malassezia furfur |
topic |
Schinus terebinthifolius antifungal antitumor cyclodextrin Malassezia furfur |
description |
In this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588 10.5935/2446-4775.20180013 |
url |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588 |
identifier_str_mv |
10.5935/2446-4775.20180013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588/pdf https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/588/html |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista Fitos Eletrônica info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista Fitos Eletrônica |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html |
dc.publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
publisher.none.fl_str_mv |
Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
dc.source.none.fl_str_mv |
Revista Fitos; Vol. 12 No. 2 (2018); 135-146 Revista Fitos; Vol. 12 Núm. 2 (2018); 135-146 Revista Fitos; v. 12 n. 2 (2018); 135-146 2446-4775 1808-9569 reponame:Revista Fitos instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Revista Fitos |
collection |
Revista Fitos |
repository.name.fl_str_mv |
Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br |
_version_ |
1798313474388918272 |