From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Revista Fitos |
| Texto Completo: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086 |
Resumo: | CoVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which has complex symptoms, affecting various human organs. Antimalarial plants can also have important pharmacological activities in the treatment of other diseases. Thus, plants with antimalarial activity have been the target of studies for the treatment of CoVID-19. The aim of this study was to verify in the scientific literature the use of medicinal plants with antimalarial activity as a potential strategy therapy in CoVID-19. Therefore, research, systematization of articles and literature reviews of plants with antimalarial, antiviral, anti-inflammatory, and immunomodulatory activity published in the last 20 years were carried out. The 27 important plant species with antimalarial activity were listed. Among these, plants of the genera Cinchona and Artemisia stood out for presenting antimalarial and antiviral activities, with the main major constituents responsible for these activities, quinine and artemisinin, respectively. Based on the findings of this study, it is possible to highlight the importance and urgency of research and development of medicines derived from plant diversity, considering the multiplicity of pharmacological actions that the selected plants present, which could potentially be applicable in therapy against CoVID-19. |
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From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapyDo quinino aos antimaláricos sintéticos: o conhecimento das plantas medicinais como estratégia potencial na terapia da CoVID-19Medicinal plantsSARS-CoV-2CoVID-19AntiviralAnti-inflammatoryImmunomodulatoryPlantas medicinaisSARS-CoV-2COVID-19Antiviralação anti-inflamatóriaImunomoduladoraCoVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which has complex symptoms, affecting various human organs. Antimalarial plants can also have important pharmacological activities in the treatment of other diseases. Thus, plants with antimalarial activity have been the target of studies for the treatment of CoVID-19. The aim of this study was to verify in the scientific literature the use of medicinal plants with antimalarial activity as a potential strategy therapy in CoVID-19. Therefore, research, systematization of articles and literature reviews of plants with antimalarial, antiviral, anti-inflammatory, and immunomodulatory activity published in the last 20 years were carried out. The 27 important plant species with antimalarial activity were listed. Among these, plants of the genera Cinchona and Artemisia stood out for presenting antimalarial and antiviral activities, with the main major constituents responsible for these activities, quinine and artemisinin, respectively. Based on the findings of this study, it is possible to highlight the importance and urgency of research and development of medicines derived from plant diversity, considering the multiplicity of pharmacological actions that the selected plants present, which could potentially be applicable in therapy against CoVID-19.CoVID-19 é uma doença infecciosa causada pelo vírus SARS-CoV-2, que apresenta uma sintomatologia complexa, atingindo vários órgãos e sistemas do organismo humano. Estudos com plantas medicinais indicam as diversas atividades farmacológicas que uma mesma espécie vegetal pode apresentar. Plantas com atividade antimalárica têm sido alvo de estudos para o tratamento da CoVID-19, através de suas ações combatendo diretamente o vírus, como na redução ou eliminação dos sintomas. O objetivo deste estudo foi verificar, na literatura científica, o uso das plantas medicinais com atividade antimalárica como potencial estratégia na terapia da CoVID-19. Foram realizadas pesquisa, sistematização de artigos e revisões da literatura de plantas com atividade antimalárica, antiviral, anti-inflamatória e imunomoduladora publicados nos últimos 20 anos. Listou-se 27 espécies de plantas importantes com atividade antimalárica. Dentre essas, plantas dos gêneros Cinchona e Artemisia destacaram-se por apresentarem atividades antimalárica e antiviral, tendo como principais constituintes majoritários, responsáveis por estas atividades, a quinina e a artemisinina, respectivamente. Foi possível destacar a importância e urgência da pesquisa e do desenvolvimento de medicamentos provenientes da diversidade vegetal, considerando a multiplicidade de ações farmacológicas que as plantas selecionadas apresentam, podendo ser potencialmente aplicáveis na terapia contra a CoVID-19.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2021-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmltext/xmltext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/108610.32712/2446-4775.2021.1086Revista Fitos; Vol. 15 No. 3 (2021); 366-384Revista Fitos; Vol. 15 Núm. 3 (2021); 366-384Revista Fitos; v. 15 n. 3 (2021); 366-3842446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/785https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/786https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/973https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/903Copyright (c) 2021 Revista Fitoshttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccess Bizarri, Carlos Henrique BrasilRezende, Mayara de AzeredoMattos, Aline Estácio Ribeiro deNóbrega, Andrea Bezerra daVillas Bôas, Glauco de Kruse2022-05-02T19:41:05Zoai:ojs.revistafitos.far.fiocruz.br:article/1086Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-05-02T19:41:05Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.none.fl_str_mv |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy Do quinino aos antimaláricos sintéticos: o conhecimento das plantas medicinais como estratégia potencial na terapia da CoVID-19 |
| title |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| spellingShingle |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy Bizarri, Carlos Henrique Brasil Medicinal plants SARS-CoV-2 CoVID-19 Antiviral Anti-inflammatory Immunomodulatory Plantas medicinais SARS-CoV-2 COVID-19 Antiviral ação anti-inflamatória Imunomoduladora |
| title_short |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| title_full |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| title_fullStr |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| title_full_unstemmed |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| title_sort |
From quinine to synthetic antimalarials: knowledge of medicinal plants as a potential strategy in CoVID-19 therapy |
| author |
Bizarri, Carlos Henrique Brasil |
| author_facet |
Bizarri, Carlos Henrique Brasil Rezende, Mayara de Azeredo Mattos, Aline Estácio Ribeiro de Nóbrega, Andrea Bezerra da Villas Bôas, Glauco de Kruse |
| author_role |
author |
| author2 |
Rezende, Mayara de Azeredo Mattos, Aline Estácio Ribeiro de Nóbrega, Andrea Bezerra da Villas Bôas, Glauco de Kruse |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Bizarri, Carlos Henrique Brasil Rezende, Mayara de Azeredo Mattos, Aline Estácio Ribeiro de Nóbrega, Andrea Bezerra da Villas Bôas, Glauco de Kruse |
| dc.subject.por.fl_str_mv |
Medicinal plants SARS-CoV-2 CoVID-19 Antiviral Anti-inflammatory Immunomodulatory Plantas medicinais SARS-CoV-2 COVID-19 Antiviral ação anti-inflamatória Imunomoduladora |
| topic |
Medicinal plants SARS-CoV-2 CoVID-19 Antiviral Anti-inflammatory Immunomodulatory Plantas medicinais SARS-CoV-2 COVID-19 Antiviral ação anti-inflamatória Imunomoduladora |
| description |
CoVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which has complex symptoms, affecting various human organs. Antimalarial plants can also have important pharmacological activities in the treatment of other diseases. Thus, plants with antimalarial activity have been the target of studies for the treatment of CoVID-19. The aim of this study was to verify in the scientific literature the use of medicinal plants with antimalarial activity as a potential strategy therapy in CoVID-19. Therefore, research, systematization of articles and literature reviews of plants with antimalarial, antiviral, anti-inflammatory, and immunomodulatory activity published in the last 20 years were carried out. The 27 important plant species with antimalarial activity were listed. Among these, plants of the genera Cinchona and Artemisia stood out for presenting antimalarial and antiviral activities, with the main major constituents responsible for these activities, quinine and artemisinin, respectively. Based on the findings of this study, it is possible to highlight the importance and urgency of research and development of medicines derived from plant diversity, considering the multiplicity of pharmacological actions that the selected plants present, which could potentially be applicable in therapy against CoVID-19. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-09-30 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086 10.32712/2446-4775.2021.1086 |
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https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086 |
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10.32712/2446-4775.2021.1086 |
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por |
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por |
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https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/785 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/786 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/973 https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1086/903 |
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Copyright (c) 2021 Revista Fitos https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Copyright (c) 2021 Revista Fitos https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf text/html text/xml text/html |
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Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
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Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz |
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Revista Fitos; Vol. 15 No. 3 (2021); 366-384 Revista Fitos; Vol. 15 Núm. 3 (2021); 366-384 Revista Fitos; v. 15 n. 3 (2021); 366-384 2446-4775 1808-9569 reponame:Revista Fitos instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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