Toxicological reproductive study of Azadirachta indica A. Juss (Neem) in female Wistar rats

• Autor(a) principal: Wanderley, A. G.
• Data de Publicação: 2005
• Outros Autores: Lyra, M. M. A., Costa-Silva, J. H., Lima, C. R., Arruda, V. M., Araújo, A. V., Ribeiro e Ribeiro, A., Arruda, A. C., Fraga, M. C. C. A., Lafayette, S. S. L.
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/24

The effects of the administration of the Azadirachta indica (Neem) seed oil was investigated at the pre-implantation stage in Wistar female rats. Three groups (n = 5-9/group) of female adult rats were treated by oral route from the 1st to the 6th day of pregnancy, in the doses of 1,0 and 2,0 g/kg body weight. On the 20th day of pregnancy, the animals were sacrificed for the evaluation of the following reproductive parameters: number of live and non-live conceptuses; relation offspring/mother; fetal weight; placental and ovarian weight; number of total uterine implantation sites; number of resorption sites; number of ovarian corpora lutea; and number of pre- and post-implantation loss. The results show that there were not statistic differences among control and treated groups on the analyzed parameters, except for the fetal weight, that was significantly reduced in relation to the control group by 10,9 and 12,1%, to the doses of 1,0 and 2,0 g/kg, respectively. In conclusion, the administration of the neem seed oil did not induce anti-implantation effect. However, the reduced fetal weight can indicate fetotoxicity.independent of the method employed.