Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine

Detalhes bibliográficos
Autor(a) principal: Conceição,Maria José
Data de Publicação: 2000
Outros Autores: Argento,Carlos Alberto, Corrêa,Acyr
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300013
Resumo: After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis. The objective of the present study was to determine the experimental behaviour of five different S. mansoni isolates in Swiss Webster mice that were submitted to treatment with the same drug. The experimental group with failure of treatment showed higher mean number of surviving male worms when it was compared to the group without failure of treatment. These date suggest the possibility of resistance to oxamniquine.
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spelling Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquineSchistosoma mansonipatientsoxamniquinefailure of treatmentAfter three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis. The objective of the present study was to determine the experimental behaviour of five different S. mansoni isolates in Swiss Webster mice that were submitted to treatment with the same drug. The experimental group with failure of treatment showed higher mean number of surviving male worms when it was compared to the group without failure of treatment. These date suggest the possibility of resistance to oxamniquine.Instituto Oswaldo Cruz, Ministério da Saúde2000-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300013Memórias do Instituto Oswaldo Cruz v.95 n.3 2000reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762000000300013info:eu-repo/semantics/openAccessConceição,Maria JoséArgento,Carlos AlbertoCorrêa,Acyreng2020-04-25T17:48:23Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:09:40.606Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
title Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
spellingShingle Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
Conceição,Maria José
Schistosoma mansoni
patients
oxamniquine
failure of treatment
title_short Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
title_full Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
title_fullStr Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
title_full_unstemmed Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
title_sort Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine
author Conceição,Maria José
author_facet Conceição,Maria José
Argento,Carlos Alberto
Corrêa,Acyr
author_role author
author2 Argento,Carlos Alberto
Corrêa,Acyr
author2_role author
author
dc.contributor.author.fl_str_mv Conceição,Maria José
Argento,Carlos Alberto
Corrêa,Acyr
dc.subject.por.fl_str_mv Schistosoma mansoni
patients
oxamniquine
failure of treatment
topic Schistosoma mansoni
patients
oxamniquine
failure of treatment
dc.description.none.fl_txt_mv After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis. The objective of the present study was to determine the experimental behaviour of five different S. mansoni isolates in Swiss Webster mice that were submitted to treatment with the same drug. The experimental group with failure of treatment showed higher mean number of surviving male worms when it was compared to the group without failure of treatment. These date suggest the possibility of resistance to oxamniquine.
description After three successive treatments with oxamniquine the continuing elimination of Schistosoma mansoni eggs was observed in patients, who came from various regions of Brazil, with different clinical forms of schistosomiasis. The objective of the present study was to determine the experimental behaviour of five different S. mansoni isolates in Swiss Webster mice that were submitted to treatment with the same drug. The experimental group with failure of treatment showed higher mean number of surviving male worms when it was compared to the group without failure of treatment. These date suggest the possibility of resistance to oxamniquine.
publishDate 2000
dc.date.none.fl_str_mv 2000-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300013
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762000000300013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.95 n.3 2000
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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