Evidence of hidden leprosy in a supposedly low endemic area of Brazil

Detalhes bibliográficos
Autor(a) principal: Bernardes Filho,Fred
Data de Publicação: 2017
Outros Autores: Paula,Natália Aparecida de, Leite,Marcel Nani, Abi-Rached,Thania Loyola Cordeiro, Vernal,Sebastian, Silva,Moises Batista da, Barreto,Josafá Gonçalves, Spencer,John Stewart, Frade,Marco Andrey Cipriani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001200822
Resumo: OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public emergency department and by active surveillance carried out during two days at a mobile clinic. All subjects received a dermato-neurological examination and blood sampling to determine anti-PGL-I antibody titers by enzyme-linked immunosorbent assay (ELISA). RESULTS From July to December 2015, 24 new cases of leprosy were diagnosed; all were classified as multibacillary (MB) leprosy, one with severe Lucio's phenomenon. Seventeen (75%) were found with grade-1 or 2 disability at the moment of diagnosis. Anti-PGL-I titer was positive in 31/133 (23.3%) individuals, only 6/24 (25%) were positive in newly diagnosed leprosy cases. CONCLUSIONS During the last ten years before this study, the average new case detection rate (NCDR) in this town was 2.62/100,000 population. After our work, the NCDR was raised to 42.8/100,000. These results indicate a very high number of hidden leprosy cases in this supposedly low endemic area of Brazil.
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spelling Evidence of hidden leprosy in a supposedly low endemic area of BrazilleprosyMycobacterium lepraeserology OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public emergency department and by active surveillance carried out during two days at a mobile clinic. All subjects received a dermato-neurological examination and blood sampling to determine anti-PGL-I antibody titers by enzyme-linked immunosorbent assay (ELISA). RESULTS From July to December 2015, 24 new cases of leprosy were diagnosed; all were classified as multibacillary (MB) leprosy, one with severe Lucio's phenomenon. Seventeen (75%) were found with grade-1 or 2 disability at the moment of diagnosis. Anti-PGL-I titer was positive in 31/133 (23.3%) individuals, only 6/24 (25%) were positive in newly diagnosed leprosy cases. CONCLUSIONS During the last ten years before this study, the average new case detection rate (NCDR) in this town was 2.62/100,000 population. After our work, the NCDR was raised to 42.8/100,000. These results indicate a very high number of hidden leprosy cases in this supposedly low endemic area of Brazil.Instituto Oswaldo Cruz, Ministério da Saúde2017-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001200822Memórias do Instituto Oswaldo Cruz v.112 n.12 2017reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760170173info:eu-repo/semantics/openAccessBernardes Filho,FredPaula,Natália Aparecida deLeite,Marcel NaniAbi-Rached,Thania Loyola CordeiroVernal,SebastianSilva,Moises Batista daBarreto,Josafá GonçalvesSpencer,John StewartFrade,Marco Andrey Ciprianieng2020-04-25T17:52:41Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:21:55.722Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Evidence of hidden leprosy in a supposedly low endemic area of Brazil
title Evidence of hidden leprosy in a supposedly low endemic area of Brazil
spellingShingle Evidence of hidden leprosy in a supposedly low endemic area of Brazil
Bernardes Filho,Fred
leprosy
Mycobacterium leprae
serology
title_short Evidence of hidden leprosy in a supposedly low endemic area of Brazil
title_full Evidence of hidden leprosy in a supposedly low endemic area of Brazil
title_fullStr Evidence of hidden leprosy in a supposedly low endemic area of Brazil
title_full_unstemmed Evidence of hidden leprosy in a supposedly low endemic area of Brazil
title_sort Evidence of hidden leprosy in a supposedly low endemic area of Brazil
author Bernardes Filho,Fred
author_facet Bernardes Filho,Fred
Paula,Natália Aparecida de
Leite,Marcel Nani
Abi-Rached,Thania Loyola Cordeiro
Vernal,Sebastian
Silva,Moises Batista da
Barreto,Josafá Gonçalves
Spencer,John Stewart
Frade,Marco Andrey Cipriani
author_role author
author2 Paula,Natália Aparecida de
Leite,Marcel Nani
Abi-Rached,Thania Loyola Cordeiro
Vernal,Sebastian
Silva,Moises Batista da
Barreto,Josafá Gonçalves
Spencer,John Stewart
Frade,Marco Andrey Cipriani
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bernardes Filho,Fred
Paula,Natália Aparecida de
Leite,Marcel Nani
Abi-Rached,Thania Loyola Cordeiro
Vernal,Sebastian
Silva,Moises Batista da
Barreto,Josafá Gonçalves
Spencer,John Stewart
Frade,Marco Andrey Cipriani
dc.subject.por.fl_str_mv leprosy
Mycobacterium leprae
serology
topic leprosy
Mycobacterium leprae
serology
dc.description.none.fl_txt_mv OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public emergency department and by active surveillance carried out during two days at a mobile clinic. All subjects received a dermato-neurological examination and blood sampling to determine anti-PGL-I antibody titers by enzyme-linked immunosorbent assay (ELISA). RESULTS From July to December 2015, 24 new cases of leprosy were diagnosed; all were classified as multibacillary (MB) leprosy, one with severe Lucio's phenomenon. Seventeen (75%) were found with grade-1 or 2 disability at the moment of diagnosis. Anti-PGL-I titer was positive in 31/133 (23.3%) individuals, only 6/24 (25%) were positive in newly diagnosed leprosy cases. CONCLUSIONS During the last ten years before this study, the average new case detection rate (NCDR) in this town was 2.62/100,000 population. After our work, the NCDR was raised to 42.8/100,000. These results indicate a very high number of hidden leprosy cases in this supposedly low endemic area of Brazil.
description OBJECTIVES Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations. METHODS The study sample was composed by people randomly selected by a dermatologist during medical care in the public emergency department and by active surveillance carried out during two days at a mobile clinic. All subjects received a dermato-neurological examination and blood sampling to determine anti-PGL-I antibody titers by enzyme-linked immunosorbent assay (ELISA). RESULTS From July to December 2015, 24 new cases of leprosy were diagnosed; all were classified as multibacillary (MB) leprosy, one with severe Lucio's phenomenon. Seventeen (75%) were found with grade-1 or 2 disability at the moment of diagnosis. Anti-PGL-I titer was positive in 31/133 (23.3%) individuals, only 6/24 (25%) were positive in newly diagnosed leprosy cases. CONCLUSIONS During the last ten years before this study, the average new case detection rate (NCDR) in this town was 2.62/100,000 population. After our work, the NCDR was raised to 42.8/100,000. These results indicate a very high number of hidden leprosy cases in this supposedly low endemic area of Brazil.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001200822
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001200822
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-02760170173
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.112 n.12 2017
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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