Screening of the antimalarial activity of plants of the Cucurbitaceae family

Detalhes bibliográficos
Autor(a) principal: Amorim,Cláudia Zuany
Data de Publicação: 1991
Outros Autores: Marques,Arthur Diaz, Cordeiro,Renato Sergio Balão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040
Resumo: Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.
id FIOCRUZ-4_180ac4293f5742d49bc3ac2755710802
oai_identifier_str oai:scielo:S0074-02761991000600040
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling Screening of the antimalarial activity of plants of the Cucurbitaceae familyantimalarialsdrug therapynatural productsplant extractsdrug screeningPlasmodium bergheicurcubita maximaMomordica charantiaCucurbitaceaeCrude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.Instituto Oswaldo Cruz, Ministério da Saúde1991-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761991000600040info:eu-repo/semantics/openAccessAmorim,Cláudia ZuanyMarques,Arthur DiazCordeiro,Renato Sergio Balãoeng2020-04-25T17:46:40Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:04:20.272Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Screening of the antimalarial activity of plants of the Cucurbitaceae family
title Screening of the antimalarial activity of plants of the Cucurbitaceae family
spellingShingle Screening of the antimalarial activity of plants of the Cucurbitaceae family
Amorim,Cláudia Zuany
antimalarials
drug therapy
natural products
plant extracts
drug screening
Plasmodium berghei
curcubita maxima
Momordica charantia
Cucurbitaceae
title_short Screening of the antimalarial activity of plants of the Cucurbitaceae family
title_full Screening of the antimalarial activity of plants of the Cucurbitaceae family
title_fullStr Screening of the antimalarial activity of plants of the Cucurbitaceae family
title_full_unstemmed Screening of the antimalarial activity of plants of the Cucurbitaceae family
title_sort Screening of the antimalarial activity of plants of the Cucurbitaceae family
author Amorim,Cláudia Zuany
author_facet Amorim,Cláudia Zuany
Marques,Arthur Diaz
Cordeiro,Renato Sergio Balão
author_role author
author2 Marques,Arthur Diaz
Cordeiro,Renato Sergio Balão
author2_role author
author
dc.contributor.author.fl_str_mv Amorim,Cláudia Zuany
Marques,Arthur Diaz
Cordeiro,Renato Sergio Balão
dc.subject.por.fl_str_mv antimalarials
drug therapy
natural products
plant extracts
drug screening
Plasmodium berghei
curcubita maxima
Momordica charantia
Cucurbitaceae
topic antimalarials
drug therapy
natural products
plant extracts
drug screening
Plasmodium berghei
curcubita maxima
Momordica charantia
Cucurbitaceae
dc.description.none.fl_txt_mv Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.
description Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.
publishDate 1991
dc.date.none.fl_str_mv 1991-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761991000600040
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937657409437696

Registros relacionados