Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region

Detalhes bibliográficos
Autor(a) principal: Ferreira,William Antunes
Data de Publicação: 2011
Outros Autores: Ferreira,Cristina Motta, Naveca,Felipe Gomes, Almeida,Nayanne Cristina Oliveira da Silva, Vasconcelos,Waldemara de Souza, Gomes,Jairo de Souza, Silva,Maria de Fátima Pinto da, Alecrim,Maria das Graças Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018
Resumo: We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.
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spelling Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon RegionNeisseria gonorrhoeaefluroquinolone resistancegyrA and parCgenotypingMASTWe report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.Instituto Oswaldo Cruz, Ministério da Saúde2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018Memórias do Instituto Oswaldo Cruz v.106 n.5 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000500018info:eu-repo/semantics/openAccessFerreira,William AntunesFerreira,Cristina MottaNaveca,Felipe GomesAlmeida,Nayanne Cristina Oliveira da SilvaVasconcelos,Waldemara de SouzaGomes,Jairo de SouzaSilva,Maria de Fátima Pinto daAlecrim,Maria das Graças Costaeng2020-04-25T17:51:02Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:46.885Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
title Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
spellingShingle Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
Ferreira,William Antunes
Neisseria gonorrhoeae
fluroquinolone resistance
gyrA and parC
genotyping
MAST
title_short Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
title_full Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
title_fullStr Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
title_full_unstemmed Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
title_sort Genotyping of two Neisseria gonorrhoeae fluroquinolone-resistant strains in the Brazilian Amazon Region
author Ferreira,William Antunes
author_facet Ferreira,William Antunes
Ferreira,Cristina Motta
Naveca,Felipe Gomes
Almeida,Nayanne Cristina Oliveira da Silva
Vasconcelos,Waldemara de Souza
Gomes,Jairo de Souza
Silva,Maria de Fátima Pinto da
Alecrim,Maria das Graças Costa
author_role author
author2 Ferreira,Cristina Motta
Naveca,Felipe Gomes
Almeida,Nayanne Cristina Oliveira da Silva
Vasconcelos,Waldemara de Souza
Gomes,Jairo de Souza
Silva,Maria de Fátima Pinto da
Alecrim,Maria das Graças Costa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira,William Antunes
Ferreira,Cristina Motta
Naveca,Felipe Gomes
Almeida,Nayanne Cristina Oliveira da Silva
Vasconcelos,Waldemara de Souza
Gomes,Jairo de Souza
Silva,Maria de Fátima Pinto da
Alecrim,Maria das Graças Costa
dc.subject.por.fl_str_mv Neisseria gonorrhoeae
fluroquinolone resistance
gyrA and parC
genotyping
MAST
topic Neisseria gonorrhoeae
fluroquinolone resistance
gyrA and parC
genotyping
MAST
dc.description.none.fl_txt_mv We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.
description We report two ciprofloxacin and ofloxacin-resistant Neisseria gonorrhoeae strains that were isolated from the urethral discharge of male patients at the sexually transmitted diseases outpatient clinic of the Alfredo da Matta Foundation (Manaus, state of Amazonas, Brazil). The gonococci displayed minimal inhibitory concentrations (> 32.00 µg/mL) and three mutations in the quinolone resistance-determining region (S91F and D95G in GyrA and S87R in ParC). Both isolates were genotyped using N. gonorrhoeae multi-antigen sequence typing and the analysis showed that the ST225 which represented an emerging widespread multi-resistant clone that has also been associated with reduced susceptibility to ceftriaxone. We recommend continued surveillance of this pathogen to assess the efficacy of anti-gonococcal antibiotics in Brazil.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000500018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.5 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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