Immunoregulatory mechanisms and Chagas' disease

Detalhes bibliográficos
Autor(a) principal: Hontebeyrie-Joskowicz,Mireille
Data de Publicação: 1992
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900015
Resumo: During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell plyclonal activation is associated to immunossupression. At the chronic stage. T cells - of the TH2 subset - participate to the pathology characteristic of Chagas'disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas'disease.
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spelling Immunoregulatory mechanisms and Chagas' diseaseTrypanosoma cruziB cell polyclonal activationimmunosuppressionTH1 and TH2 subsetsB1 (CD5 B) cellsimmunopathologyDuring the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell plyclonal activation is associated to immunossupression. At the chronic stage. T cells - of the TH2 subset - participate to the pathology characteristic of Chagas'disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas'disease.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900015Memórias do Instituto Oswaldo Cruz v.87 suppl.5 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000900015info:eu-repo/semantics/openAccessHontebeyrie-Joskowicz,Mireilleeng2020-04-25T17:47:05Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:28.214Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Immunoregulatory mechanisms and Chagas' disease
title Immunoregulatory mechanisms and Chagas' disease
spellingShingle Immunoregulatory mechanisms and Chagas' disease
Hontebeyrie-Joskowicz,Mireille
Trypanosoma cruzi
B cell polyclonal activation
immunosuppression
TH1 and TH2 subsets
B1 (CD5 B) cells
immunopathology
title_short Immunoregulatory mechanisms and Chagas' disease
title_full Immunoregulatory mechanisms and Chagas' disease
title_fullStr Immunoregulatory mechanisms and Chagas' disease
title_full_unstemmed Immunoregulatory mechanisms and Chagas' disease
title_sort Immunoregulatory mechanisms and Chagas' disease
author Hontebeyrie-Joskowicz,Mireille
author_facet Hontebeyrie-Joskowicz,Mireille
author_role author
dc.contributor.author.fl_str_mv Hontebeyrie-Joskowicz,Mireille
dc.subject.por.fl_str_mv Trypanosoma cruzi
B cell polyclonal activation
immunosuppression
TH1 and TH2 subsets
B1 (CD5 B) cells
immunopathology
topic Trypanosoma cruzi
B cell polyclonal activation
immunosuppression
TH1 and TH2 subsets
B1 (CD5 B) cells
immunopathology
dc.description.none.fl_txt_mv During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell plyclonal activation is associated to immunossupression. At the chronic stage. T cells - of the TH2 subset - participate to the pathology characteristic of Chagas'disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas'disease.
description During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell plyclonal activation is associated to immunossupression. At the chronic stage. T cells - of the TH2 subset - participate to the pathology characteristic of Chagas'disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas'disease.
publishDate 1992
dc.date.none.fl_str_mv 1992-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900015
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000900015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 suppl.5 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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