Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Riveau,Gilles
Data de Publicação: 1998
Outros Autores: Poulain-Godefroy,Odile, Dupré,Loïc, Remoué,Franck, Mielcarek,Nathalie, Locht,Camille, Capron,André
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012
Resumo: For the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented.
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spelling Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasisschistosomiasis28GSTvaccineimmune responselive vectorsnucleic acid vaccineFor the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented.Instituto Oswaldo Cruz, Ministério da Saúde1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012Memórias do Instituto Oswaldo Cruz v.93 suppl.1 1998reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761998000700012info:eu-repo/semantics/openAccessRiveau,GillesPoulain-Godefroy,OdileDupré,LoïcRemoué,FranckMielcarek,NathalieLocht,CamilleCapron,Andréeng2020-04-25T17:47:58Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:08:27.836Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
title Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
spellingShingle Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
Riveau,Gilles
schistosomiasis
28GST
vaccine
immune response
live vectors
nucleic acid vaccine
title_short Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
title_full Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
title_fullStr Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
title_full_unstemmed Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
title_sort Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
author Riveau,Gilles
author_facet Riveau,Gilles
Poulain-Godefroy,Odile
Dupré,Loïc
Remoué,Franck
Mielcarek,Nathalie
Locht,Camille
Capron,André
author_role author
author2 Poulain-Godefroy,Odile
Dupré,Loïc
Remoué,Franck
Mielcarek,Nathalie
Locht,Camille
Capron,André
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Riveau,Gilles
Poulain-Godefroy,Odile
Dupré,Loïc
Remoué,Franck
Mielcarek,Nathalie
Locht,Camille
Capron,André
dc.subject.por.fl_str_mv schistosomiasis
28GST
vaccine
immune response
live vectors
nucleic acid vaccine
topic schistosomiasis
28GST
vaccine
immune response
live vectors
nucleic acid vaccine
dc.description.none.fl_txt_mv For the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented.
description For the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented.
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761998000700012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.93 suppl.1 1998
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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