A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800006 |
Resumo: | The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack of a complete assembly of the genomic sequence and the presence of many predicted proteins with unknown or unsure functions has hampered our complete view of the parasite's metabolic pathways. Moreover, pinpointing new drug targets has proven to be more complex than anticipated and has revealed large holes in our understanding of metabolic pathways and their integrated regulation, not only for this parasite, but for many other similar pathogens. Using an in silicocomparative study on pathway annotation and searching for analogous and specific enzymes, we have been able to predict a considerable number of additional enzymatic functions in T. cruzi. Here we focus on the energetic pathways, such as glycolysis, the pentose phosphate shunt, the Krebs cycle and lipid metabolism. We point out many enzymes that are analogous to those of the human host, which could be potential new therapeutic targets. |
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Memórias do Instituto Oswaldo Cruz |
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A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome informationTrypanosoma cruzimetabolismmetabolic pathwaysdrug targetanalogous enzymeThe current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack of a complete assembly of the genomic sequence and the presence of many predicted proteins with unknown or unsure functions has hampered our complete view of the parasite's metabolic pathways. Moreover, pinpointing new drug targets has proven to be more complex than anticipated and has revealed large holes in our understanding of metabolic pathways and their integrated regulation, not only for this parasite, but for many other similar pathogens. Using an in silicocomparative study on pathway annotation and searching for analogous and specific enzymes, we have been able to predict a considerable number of additional enzymatic functions in T. cruzi. Here we focus on the energetic pathways, such as glycolysis, the pentose phosphate shunt, the Krebs cycle and lipid metabolism. We point out many enzymes that are analogous to those of the human host, which could be potential new therapeutic targets.Instituto Oswaldo Cruz, Ministério da Saúde2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800006Memórias do Instituto Oswaldo Cruz v.104 n.8 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000800006info:eu-repo/semantics/openAccessAlves-Ferreira,MarceloGuimarães,Ana Carolina RamosCapriles,Priscila Vanessa da Silva ZabalaDardenne,Laurent EDegrave,Wim Meng2020-04-25T17:50:34Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:32.491Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
title |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
spellingShingle |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information Alves-Ferreira,Marcelo Trypanosoma cruzi metabolism metabolic pathways drug target analogous enzyme |
title_short |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
title_full |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
title_fullStr |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
title_full_unstemmed |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
title_sort |
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information |
author |
Alves-Ferreira,Marcelo |
author_facet |
Alves-Ferreira,Marcelo Guimarães,Ana Carolina Ramos Capriles,Priscila Vanessa da Silva Zabala Dardenne,Laurent E Degrave,Wim M |
author_role |
author |
author2 |
Guimarães,Ana Carolina Ramos Capriles,Priscila Vanessa da Silva Zabala Dardenne,Laurent E Degrave,Wim M |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Alves-Ferreira,Marcelo Guimarães,Ana Carolina Ramos Capriles,Priscila Vanessa da Silva Zabala Dardenne,Laurent E Degrave,Wim M |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi metabolism metabolic pathways drug target analogous enzyme |
topic |
Trypanosoma cruzi metabolism metabolic pathways drug target analogous enzyme |
dc.description.none.fl_txt_mv |
The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack of a complete assembly of the genomic sequence and the presence of many predicted proteins with unknown or unsure functions has hampered our complete view of the parasite's metabolic pathways. Moreover, pinpointing new drug targets has proven to be more complex than anticipated and has revealed large holes in our understanding of metabolic pathways and their integrated regulation, not only for this parasite, but for many other similar pathogens. Using an in silicocomparative study on pathway annotation and searching for analogous and specific enzymes, we have been able to predict a considerable number of additional enzymatic functions in T. cruzi. Here we focus on the energetic pathways, such as glycolysis, the pentose phosphate shunt, the Krebs cycle and lipid metabolism. We point out many enzymes that are analogous to those of the human host, which could be potential new therapeutic targets. |
description |
The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack of a complete assembly of the genomic sequence and the presence of many predicted proteins with unknown or unsure functions has hampered our complete view of the parasite's metabolic pathways. Moreover, pinpointing new drug targets has proven to be more complex than anticipated and has revealed large holes in our understanding of metabolic pathways and their integrated regulation, not only for this parasite, but for many other similar pathogens. Using an in silicocomparative study on pathway annotation and searching for analogous and specific enzymes, we have been able to predict a considerable number of additional enzymatic functions in T. cruzi. Here we focus on the energetic pathways, such as glycolysis, the pentose phosphate shunt, the Krebs cycle and lipid metabolism. We point out many enzymes that are analogous to those of the human host, which could be potential new therapeutic targets. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800006 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000800006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762009000800006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.104 n.8 2009 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937706729209856 |