Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches

Detalhes bibliográficos
Autor(a) principal: Noya,Belkisyolé Alarcón de
Data de Publicação: 2015
Outros Autores: Díaz-Bello,Zoraida, Colmenares,Cecilia, Ruiz-Guevara,Raiza, Mauriello,Luciano, Muñoz-Calderón,Arturo, Noya,Oscar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300377
Resumo: Orally transmitted Chagas disease has become a matter of concern due to outbreaks reported in four Latin American countries. Although several mechanisms for orally transmitted Chagas disease transmission have been proposed, food and beverages contaminated with whole infected triatomines or their faeces, which contain metacyclic trypomastigotes of Trypanosoma cruzi, seems to be the primary vehicle. In 2007, the first recognised outbreak of orally transmitted Chagas disease occurred in Venezuela and largest recorded outbreak at that time. Since then, 10 outbreaks (four in Caracas) with 249 cases (73.5% children) and 4% mortality have occurred. The absence of contact with the vector and of traditional cutaneous and Romana’s signs, together with a florid spectrum of clinical manifestations during the acute phase, confuse the diagnosis of orally transmitted Chagas disease with other infectious diseases. The simultaneous detection of IgG and IgM by ELISA and the search for parasites in all individuals at risk have been valuable diagnostic tools for detecting acute cases. Follow-up studies regarding the microepidemics primarily affecting children has resulted in 70% infection persistence six years after anti-parasitic treatment. Panstrongylus geniculatushas been the incriminating vector in most cases. As a food-borne disease, this entity requires epidemiological, clinical, diagnostic and therapeutic approaches that differ from those approaches used for traditional direct or cutaneous vector transmission.
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spelling Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approachesChagas diseaseoral transmissionoutbreaksVenezuelaOrally transmitted Chagas disease has become a matter of concern due to outbreaks reported in four Latin American countries. Although several mechanisms for orally transmitted Chagas disease transmission have been proposed, food and beverages contaminated with whole infected triatomines or their faeces, which contain metacyclic trypomastigotes of Trypanosoma cruzi, seems to be the primary vehicle. In 2007, the first recognised outbreak of orally transmitted Chagas disease occurred in Venezuela and largest recorded outbreak at that time. Since then, 10 outbreaks (four in Caracas) with 249 cases (73.5% children) and 4% mortality have occurred. The absence of contact with the vector and of traditional cutaneous and Romana’s signs, together with a florid spectrum of clinical manifestations during the acute phase, confuse the diagnosis of orally transmitted Chagas disease with other infectious diseases. The simultaneous detection of IgG and IgM by ELISA and the search for parasites in all individuals at risk have been valuable diagnostic tools for detecting acute cases. Follow-up studies regarding the microepidemics primarily affecting children has resulted in 70% infection persistence six years after anti-parasitic treatment. Panstrongylus geniculatushas been the incriminating vector in most cases. As a food-borne disease, this entity requires epidemiological, clinical, diagnostic and therapeutic approaches that differ from those approaches used for traditional direct or cutaneous vector transmission.Instituto Oswaldo Cruz, Ministério da Saúde2015-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300377Memórias do Instituto Oswaldo Cruz v.110 n.3 2015reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760140285info:eu-repo/semantics/openAccessNoya,Belkisyolé Alarcón deDíaz-Bello,ZoraidaColmenares,CeciliaRuiz-Guevara,RaizaMauriello,LucianoMuñoz-Calderón,ArturoNoya,Oscareng2020-04-25T17:52:12Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:20:41.488Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
title Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
spellingShingle Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
Noya,Belkisyolé Alarcón de
Chagas disease
oral transmission
outbreaks
Venezuela
title_short Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
title_full Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
title_fullStr Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
title_full_unstemmed Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
title_sort Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches
author Noya,Belkisyolé Alarcón de
author_facet Noya,Belkisyolé Alarcón de
Díaz-Bello,Zoraida
Colmenares,Cecilia
Ruiz-Guevara,Raiza
Mauriello,Luciano
Muñoz-Calderón,Arturo
Noya,Oscar
author_role author
author2 Díaz-Bello,Zoraida
Colmenares,Cecilia
Ruiz-Guevara,Raiza
Mauriello,Luciano
Muñoz-Calderón,Arturo
Noya,Oscar
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Noya,Belkisyolé Alarcón de
Díaz-Bello,Zoraida
Colmenares,Cecilia
Ruiz-Guevara,Raiza
Mauriello,Luciano
Muñoz-Calderón,Arturo
Noya,Oscar
dc.subject.por.fl_str_mv Chagas disease
oral transmission
outbreaks
Venezuela
topic Chagas disease
oral transmission
outbreaks
Venezuela
dc.description.none.fl_txt_mv Orally transmitted Chagas disease has become a matter of concern due to outbreaks reported in four Latin American countries. Although several mechanisms for orally transmitted Chagas disease transmission have been proposed, food and beverages contaminated with whole infected triatomines or their faeces, which contain metacyclic trypomastigotes of Trypanosoma cruzi, seems to be the primary vehicle. In 2007, the first recognised outbreak of orally transmitted Chagas disease occurred in Venezuela and largest recorded outbreak at that time. Since then, 10 outbreaks (four in Caracas) with 249 cases (73.5% children) and 4% mortality have occurred. The absence of contact with the vector and of traditional cutaneous and Romana’s signs, together with a florid spectrum of clinical manifestations during the acute phase, confuse the diagnosis of orally transmitted Chagas disease with other infectious diseases. The simultaneous detection of IgG and IgM by ELISA and the search for parasites in all individuals at risk have been valuable diagnostic tools for detecting acute cases. Follow-up studies regarding the microepidemics primarily affecting children has resulted in 70% infection persistence six years after anti-parasitic treatment. Panstrongylus geniculatushas been the incriminating vector in most cases. As a food-borne disease, this entity requires epidemiological, clinical, diagnostic and therapeutic approaches that differ from those approaches used for traditional direct or cutaneous vector transmission.
description Orally transmitted Chagas disease has become a matter of concern due to outbreaks reported in four Latin American countries. Although several mechanisms for orally transmitted Chagas disease transmission have been proposed, food and beverages contaminated with whole infected triatomines or their faeces, which contain metacyclic trypomastigotes of Trypanosoma cruzi, seems to be the primary vehicle. In 2007, the first recognised outbreak of orally transmitted Chagas disease occurred in Venezuela and largest recorded outbreak at that time. Since then, 10 outbreaks (four in Caracas) with 249 cases (73.5% children) and 4% mortality have occurred. The absence of contact with the vector and of traditional cutaneous and Romana’s signs, together with a florid spectrum of clinical manifestations during the acute phase, confuse the diagnosis of orally transmitted Chagas disease with other infectious diseases. The simultaneous detection of IgG and IgM by ELISA and the search for parasites in all individuals at risk have been valuable diagnostic tools for detecting acute cases. Follow-up studies regarding the microepidemics primarily affecting children has resulted in 70% infection persistence six years after anti-parasitic treatment. Panstrongylus geniculatushas been the incriminating vector in most cases. As a food-borne disease, this entity requires epidemiological, clinical, diagnostic and therapeutic approaches that differ from those approaches used for traditional direct or cutaneous vector transmission.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300377
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300377
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-02760140285
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.110 n.3 2015
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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