On cytoadhesion of Plasmodium vivax: raison d'être?

Detalhes bibliográficos
Autor(a) principal: Costa,Fabio TM
Data de Publicação: 2011
Outros Autores: Lopes,Stefanie CP, Ferrer,Mireia, Leite,Juliana A, Martin-Jaular,Lorena, Bernabeu,Maria, Nogueira,Paulo A, Mourão,Maria Paula G, Fernandez-Becerra,Carmen, Lacerda,Marcus VG, Portillo,Hernando del
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010
Resumo: It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
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spelling On cytoadhesion of Plasmodium vivax: raison d'être?Plasmodium vivaxmalariacytoadherencesevere diseaseIt is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.Instituto Oswaldo Cruz, Ministério da Saúde2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010Memórias do Instituto Oswaldo Cruz v.106 suppl.1 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000900010info:eu-repo/semantics/openAccessCosta,Fabio TMLopes,Stefanie CPFerrer,MireiaLeite,Juliana AMartin-Jaular,LorenaBernabeu,MariaNogueira,Paulo AMourão,Maria Paula GFernandez-Becerra,CarmenLacerda,Marcus VGPortillo,Hernando deleng2020-04-25T17:51:07Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:03.005Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv On cytoadhesion of Plasmodium vivax: raison d'être?
title On cytoadhesion of Plasmodium vivax: raison d'être?
spellingShingle On cytoadhesion of Plasmodium vivax: raison d'être?
Costa,Fabio TM
Plasmodium vivax
malaria
cytoadherence
severe disease
title_short On cytoadhesion of Plasmodium vivax: raison d'être?
title_full On cytoadhesion of Plasmodium vivax: raison d'être?
title_fullStr On cytoadhesion of Plasmodium vivax: raison d'être?
title_full_unstemmed On cytoadhesion of Plasmodium vivax: raison d'être?
title_sort On cytoadhesion of Plasmodium vivax: raison d'être?
author Costa,Fabio TM
author_facet Costa,Fabio TM
Lopes,Stefanie CP
Ferrer,Mireia
Leite,Juliana A
Martin-Jaular,Lorena
Bernabeu,Maria
Nogueira,Paulo A
Mourão,Maria Paula G
Fernandez-Becerra,Carmen
Lacerda,Marcus VG
Portillo,Hernando del
author_role author
author2 Lopes,Stefanie CP
Ferrer,Mireia
Leite,Juliana A
Martin-Jaular,Lorena
Bernabeu,Maria
Nogueira,Paulo A
Mourão,Maria Paula G
Fernandez-Becerra,Carmen
Lacerda,Marcus VG
Portillo,Hernando del
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa,Fabio TM
Lopes,Stefanie CP
Ferrer,Mireia
Leite,Juliana A
Martin-Jaular,Lorena
Bernabeu,Maria
Nogueira,Paulo A
Mourão,Maria Paula G
Fernandez-Becerra,Carmen
Lacerda,Marcus VG
Portillo,Hernando del
dc.subject.por.fl_str_mv Plasmodium vivax
malaria
cytoadherence
severe disease
topic Plasmodium vivax
malaria
cytoadherence
severe disease
dc.description.none.fl_txt_mv It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
description It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000900010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 suppl.1 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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