On cytoadhesion of Plasmodium vivax: raison d'être?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010 |
Resumo: | It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite. |
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Memórias do Instituto Oswaldo Cruz |
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On cytoadhesion of Plasmodium vivax: raison d'être?Plasmodium vivaxmalariacytoadherencesevere diseaseIt is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.Instituto Oswaldo Cruz, Ministério da Saúde2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010Memórias do Instituto Oswaldo Cruz v.106 suppl.1 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000900010info:eu-repo/semantics/openAccessCosta,Fabio TMLopes,Stefanie CPFerrer,MireiaLeite,Juliana AMartin-Jaular,LorenaBernabeu,MariaNogueira,Paulo AMourão,Maria Paula GFernandez-Becerra,CarmenLacerda,Marcus VGPortillo,Hernando deleng2020-04-25T17:51:07Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:03.005Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
On cytoadhesion of Plasmodium vivax: raison d'être? |
title |
On cytoadhesion of Plasmodium vivax: raison d'être? |
spellingShingle |
On cytoadhesion of Plasmodium vivax: raison d'être? Costa,Fabio TM Plasmodium vivax malaria cytoadherence severe disease |
title_short |
On cytoadhesion of Plasmodium vivax: raison d'être? |
title_full |
On cytoadhesion of Plasmodium vivax: raison d'être? |
title_fullStr |
On cytoadhesion of Plasmodium vivax: raison d'être? |
title_full_unstemmed |
On cytoadhesion of Plasmodium vivax: raison d'être? |
title_sort |
On cytoadhesion of Plasmodium vivax: raison d'être? |
author |
Costa,Fabio TM |
author_facet |
Costa,Fabio TM Lopes,Stefanie CP Ferrer,Mireia Leite,Juliana A Martin-Jaular,Lorena Bernabeu,Maria Nogueira,Paulo A Mourão,Maria Paula G Fernandez-Becerra,Carmen Lacerda,Marcus VG Portillo,Hernando del |
author_role |
author |
author2 |
Lopes,Stefanie CP Ferrer,Mireia Leite,Juliana A Martin-Jaular,Lorena Bernabeu,Maria Nogueira,Paulo A Mourão,Maria Paula G Fernandez-Becerra,Carmen Lacerda,Marcus VG Portillo,Hernando del |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa,Fabio TM Lopes,Stefanie CP Ferrer,Mireia Leite,Juliana A Martin-Jaular,Lorena Bernabeu,Maria Nogueira,Paulo A Mourão,Maria Paula G Fernandez-Becerra,Carmen Lacerda,Marcus VG Portillo,Hernando del |
dc.subject.por.fl_str_mv |
Plasmodium vivax malaria cytoadherence severe disease |
topic |
Plasmodium vivax malaria cytoadherence severe disease |
dc.description.none.fl_txt_mv |
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite. |
description |
It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000900010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762011000900010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.106 suppl.1 2011 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937710990622720 |