Biofilm production by multiresistant Corynebacterium striatumassociated with nosocomial outbreak

• Autor(a) principal: Souza,Cassius de
• Data de Publicação: 2015
• Outros Autores: Faria,Yuri Vieira, Sant’Anna,Lincoln de Oliveira, Viana,Vanilda Gonçalves, Seabra,Sérgio Henrique, Souza,Mônica Cristina de, Vieira,Verônica Viana, Hirata Júnior,Raphael, Moreira,Lílian de Oliveira, Mattos-Guaraldi,Ana Luíza de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Memórias do Instituto Oswaldo Cruz
• Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200242
• topic: biofilm; Corynebacterium striatum; epidemic clone; fibrinogen; multi-resistance; nosocomial outbreak

Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs). We investigated the biofilm production on abiotic surfaces of multidrug-resistant (MDR) and multidrug-susceptible (MDS) strains of C. striatum of pulsed-field gel electrophoresis types I-MDR, II-MDR, III-MDS and IV-MDS isolated during a nosocomial outbreak in Rio de Janeiro, Brazil. The results showed that C. striatum was able to adhere to hydrophilic and hydrophobic abiotic surfaces. The C. striatum1987/I-MDR strain, predominantly isolated from patients undergoing endotracheal intubation procedures, showed the greatest ability to adhere to all surfaces. C. striatumbound fibrinogen to its surface, which contributed to biofilm formation. Scanning electron microscopy showed the production of mature biofilms on polyurethane catheters by all pulsotypes. In conclusion, biofilm production may contribute to the establishment of HAIs caused by C. striatum.