Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100022 |
Resumo: | Little is known about the molecular mechanisms underlying the release of merozoites from malaria infected erythrocytes. In this study membranous structures present in the culture medium at the time of merozoite release have been characterized. Biochemical and ultrastructural evidence indicate that membranous structures consist of the infected erythrocyte membrane, the parasitophorous vacuolar membrane and a residual body containing electron dense material. These are subcellular compartments expected in a structure that arises as a consequence of merozoite release from the infected cell. Ultrastructural studies show that a novel structure extends from the former parasite compartment to the surface membrane. Since these membrane modifications are detected only after merozoites have been released from the infected erythrocyte, it is proposed that they might play a role in the release of merozoites from the host cell |
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Memórias do Instituto Oswaldo Cruz |
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Identification of Novel Membrane Structures in Plasmodium falciparum Infected ErythrocytesPlasmodium falciparumparasite releasemembrane fusionparasitophorous vacuolar membraneLittle is known about the molecular mechanisms underlying the release of merozoites from malaria infected erythrocytes. In this study membranous structures present in the culture medium at the time of merozoite release have been characterized. Biochemical and ultrastructural evidence indicate that membranous structures consist of the infected erythrocyte membrane, the parasitophorous vacuolar membrane and a residual body containing electron dense material. These are subcellular compartments expected in a structure that arises as a consequence of merozoite release from the infected cell. Ultrastructural studies show that a novel structure extends from the former parasite compartment to the surface membrane. Since these membrane modifications are detected only after merozoites have been released from the infected erythrocyte, it is proposed that they might play a role in the release of merozoites from the host cellInstituto Oswaldo Cruz, Ministério da Saúde1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100022Memórias do Instituto Oswaldo Cruz v.93 n.1 1998reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761998000100022info:eu-repo/semantics/openAccessClavijo,Carlos AMora,Carlos AWinograd,Enriqueeng2020-04-25T17:47:49Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:07:57.295Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
title |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
spellingShingle |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes Clavijo,Carlos A Plasmodium falciparum parasite release membrane fusion parasitophorous vacuolar membrane |
title_short |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
title_full |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
title_fullStr |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
title_full_unstemmed |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
title_sort |
Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes |
author |
Clavijo,Carlos A |
author_facet |
Clavijo,Carlos A Mora,Carlos A Winograd,Enrique |
author_role |
author |
author2 |
Mora,Carlos A Winograd,Enrique |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Clavijo,Carlos A Mora,Carlos A Winograd,Enrique |
dc.subject.por.fl_str_mv |
Plasmodium falciparum parasite release membrane fusion parasitophorous vacuolar membrane |
topic |
Plasmodium falciparum parasite release membrane fusion parasitophorous vacuolar membrane |
dc.description.none.fl_txt_mv |
Little is known about the molecular mechanisms underlying the release of merozoites from malaria infected erythrocytes. In this study membranous structures present in the culture medium at the time of merozoite release have been characterized. Biochemical and ultrastructural evidence indicate that membranous structures consist of the infected erythrocyte membrane, the parasitophorous vacuolar membrane and a residual body containing electron dense material. These are subcellular compartments expected in a structure that arises as a consequence of merozoite release from the infected cell. Ultrastructural studies show that a novel structure extends from the former parasite compartment to the surface membrane. Since these membrane modifications are detected only after merozoites have been released from the infected erythrocyte, it is proposed that they might play a role in the release of merozoites from the host cell |
description |
Little is known about the molecular mechanisms underlying the release of merozoites from malaria infected erythrocytes. In this study membranous structures present in the culture medium at the time of merozoite release have been characterized. Biochemical and ultrastructural evidence indicate that membranous structures consist of the infected erythrocyte membrane, the parasitophorous vacuolar membrane and a residual body containing electron dense material. These are subcellular compartments expected in a structure that arises as a consequence of merozoite release from the infected cell. Ultrastructural studies show that a novel structure extends from the former parasite compartment to the surface membrane. Since these membrane modifications are detected only after merozoites have been released from the infected erythrocyte, it is proposed that they might play a role in the release of merozoites from the host cell |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100022 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02761998000100022 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.93 n.1 1998 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937671675314176 |