Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum

Detalhes bibliográficos
Autor(a) principal: Awasthi,Gauri
Data de Publicação: 2012
Outros Autores: Satya,Godavarthi Bhogendra Krishna, Das,Aparup
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100018
Resumo: Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.
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spelling Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparumCQR-Pfcrt haplotypesmalariaevolutionMutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.Instituto Oswaldo Cruz, Ministério da Saúde2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100018Memórias do Instituto Oswaldo Cruz v.107 n.1 2012reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762012000100018info:eu-repo/semantics/openAccessAwasthi,GauriSatya,Godavarthi Bhogendra KrishnaDas,Aparupeng2020-04-25T17:51:09Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:10.112Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
title Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
spellingShingle Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
Awasthi,Gauri
CQR-Pfcrt haplotypes
malaria
evolution
title_short Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
title_full Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
title_fullStr Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
title_full_unstemmed Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
title_sort Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
author Awasthi,Gauri
author_facet Awasthi,Gauri
Satya,Godavarthi Bhogendra Krishna
Das,Aparup
author_role author
author2 Satya,Godavarthi Bhogendra Krishna
Das,Aparup
author2_role author
author
dc.contributor.author.fl_str_mv Awasthi,Gauri
Satya,Godavarthi Bhogendra Krishna
Das,Aparup
dc.subject.por.fl_str_mv CQR-Pfcrt haplotypes
malaria
evolution
topic CQR-Pfcrt haplotypes
malaria
evolution
dc.description.none.fl_txt_mv Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.
description Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100018
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000100018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762012000100018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.107 n.1 2012
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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