Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000500319 |
Resumo: | This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016. A significant increase in Guillain-Barré syndrome in adults has also been reported. Factors involved in viral dissemination, neural pathogenesis and routes of transmission in Brazil are examined, such as the role of social and environmental factors and the controversies involved in the hypothesis of antibody-dependent enhancement, to explain the incidence of congenital Zika syndrome in Brazil. Responses to the Zika outbreak and the development of new products are also discussed. |
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Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A ReviewZikamicrocephalycongenital Zika syndromeneurological disorderspathogenesisepidemiologyThis article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016. A significant increase in Guillain-Barré syndrome in adults has also been reported. Factors involved in viral dissemination, neural pathogenesis and routes of transmission in Brazil are examined, such as the role of social and environmental factors and the controversies involved in the hypothesis of antibody-dependent enhancement, to explain the incidence of congenital Zika syndrome in Brazil. Responses to the Zika outbreak and the development of new products are also discussed.Instituto Oswaldo Cruz, Ministério da Saúde2017-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000500319Memórias do Instituto Oswaldo Cruz v.112 n.5 2017reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760160510info:eu-repo/semantics/openAccessPossas,CristinaBrasil,PatriciaMarzochi,Mauro CATanuri,AmilcarMartins,Reinaldo MMarques,Ernesto TABonaldo,Myrna CFerreira,Antonio GPLourenço-de-Oliveira,RicardoNogueira,Rita Maria RSequeira,Patricia CMarzochi,Keyla BFHomma,Akiraeng2020-04-25T17:52:43Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:22:00.51Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
title |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
spellingShingle |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review Possas,Cristina Zika microcephaly congenital Zika syndrome neurological disorders pathogenesis epidemiology |
title_short |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
title_full |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
title_fullStr |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
title_full_unstemmed |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
title_sort |
Zika puzzle in Brazil: peculiar conditions of viral introduction and dissemination - A Review |
author |
Possas,Cristina |
author_facet |
Possas,Cristina Brasil,Patricia Marzochi,Mauro CA Tanuri,Amilcar Martins,Reinaldo M Marques,Ernesto TA Bonaldo,Myrna C Ferreira,Antonio GP Lourenço-de-Oliveira,Ricardo Nogueira,Rita Maria R Sequeira,Patricia C Marzochi,Keyla BF Homma,Akira |
author_role |
author |
author2 |
Brasil,Patricia Marzochi,Mauro CA Tanuri,Amilcar Martins,Reinaldo M Marques,Ernesto TA Bonaldo,Myrna C Ferreira,Antonio GP Lourenço-de-Oliveira,Ricardo Nogueira,Rita Maria R Sequeira,Patricia C Marzochi,Keyla BF Homma,Akira |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Possas,Cristina Brasil,Patricia Marzochi,Mauro CA Tanuri,Amilcar Martins,Reinaldo M Marques,Ernesto TA Bonaldo,Myrna C Ferreira,Antonio GP Lourenço-de-Oliveira,Ricardo Nogueira,Rita Maria R Sequeira,Patricia C Marzochi,Keyla BF Homma,Akira |
dc.subject.por.fl_str_mv |
Zika microcephaly congenital Zika syndrome neurological disorders pathogenesis epidemiology |
topic |
Zika microcephaly congenital Zika syndrome neurological disorders pathogenesis epidemiology |
dc.description.none.fl_txt_mv |
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016. A significant increase in Guillain-Barré syndrome in adults has also been reported. Factors involved in viral dissemination, neural pathogenesis and routes of transmission in Brazil are examined, such as the role of social and environmental factors and the controversies involved in the hypothesis of antibody-dependent enhancement, to explain the incidence of congenital Zika syndrome in Brazil. Responses to the Zika outbreak and the development of new products are also discussed. |
description |
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016. A significant increase in Guillain-Barré syndrome in adults has also been reported. Factors involved in viral dissemination, neural pathogenesis and routes of transmission in Brazil are examined, such as the role of social and environmental factors and the controversies involved in the hypothesis of antibody-dependent enhancement, to explain the incidence of congenital Zika syndrome in Brazil. Responses to the Zika outbreak and the development of new products are also discussed. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000500319 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000500319 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0074-02760160510 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.112 n.5 2017 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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1669937724197437440 |